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Sgcz sarcoglycan zeta [ Mus musculus (house mouse) ]

Gene ID: 244431, updated on 2-Nov-2024

Summary

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Official Symbol
Sgczprovided by MGI
Official Full Name
sarcoglycan zetaprovided by MGI
Primary source
MGI:MGI:2388820
See related
Ensembl:ENSMUSG00000039539 AllianceGenome:MGI:2388820
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C230085N17Rik
Summary
Predicted to be involved in cardiac muscle tissue development and heart contraction. Predicted to act upstream of or within membrane organization. Located in plasma membrane. Part of sarcoglycan complex. Orthologous to human SGCZ (sarcoglycan zeta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Sgcz in Genome Data Viewer
Location:
8 A4; 8 23.31 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (37984994..39128857, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (37517840..38661705, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21233 Neighboring gene predicted gene, 25126 Neighboring gene STARR-seq mESC enhancer starr_21236 Neighboring gene STARR-seq mESC enhancer starr_21237 Neighboring gene STARR-seq mESC enhancer starr_21238 Neighboring gene STARR-seq mESC enhancer starr_21239 Neighboring gene tubulin, alpha 1C pseudogene Neighboring gene STARR-seq mESC enhancer starr_21240 Neighboring gene forkhead box N2 pseudogene Neighboring gene DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 pseudogene Neighboring gene nuclear encoded tRNA leucine 2 (anticodon CAG) Neighboring gene STARR-seq mESC enhancer starr_21243 Neighboring gene microRNA 383 Neighboring gene predicted gene, 18211 Neighboring gene STARR-seq mESC enhancer starr_21244 Neighboring gene STARR-seq mESC enhancer starr_21246 Neighboring gene STARR-seq mESC enhancer starr_21247 Neighboring gene predicted gene, 40493 Neighboring gene STARR-seq mESC enhancer starr_21248 Neighboring gene STARR-seq mESC enhancer starr_21249 Neighboring gene STARR-seq mESC enhancer starr_21250 Neighboring gene predicted gene, 23128 Neighboring gene STARR-seq mESC enhancer starr_21252 Neighboring gene STARR-seq mESC enhancer starr_21253 Neighboring gene STARR-positive B cell enhancer mm9_chr8:40240716-40241017 Neighboring gene tumor suppressor candidate 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zeta-sarcoglycan is a functional homologue of gamma-sarcoglycan in the formation of the sarcoglycan complex. Shiga K, et al. Exp Cell Res, 2006 Jul 1. PMID 16635485
  2. Collaborative cross mice in a genetic association study reveal new candidate genes for bone microarchitecture. Levy R, et al. BMC Genomics, 2015 Nov 26. PMID 26611327, Free PMC Article
  3. Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy. Wheeler MT, et al. Hum Mol Genet, 2002 Sep 1. PMID 12189167
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zeta-sarcoglycan is an integral component of the sarcoglycan complex and is important in the pathogenesis of muscular dystrophy.
    Title: Zeta-sarcoglycan, a novel component of the sarcoglycan complex, is reduced in muscular dystrophy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC123465, MGC123466

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heart contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within membrane organization TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of sarcoglycan complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sarcoglycan complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sarcolemma IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zeta-sarcoglycan
Names
ZSG1
zeta-SG

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145841.2 → NP_665840.2  zeta-sarcoglycan

    See identical proteins and their annotated locations for NP_665840.2

    Status: VALIDATED

    Source sequence(s)
    AK136779
    Consensus CDS
    CCDS22251.2
    UniProtKB/Swiss-Prot
    Q3UVZ2, Q8BX51, Q8K1E7
    UniProtKB/TrEMBL
    Q3SXX6
    Related
    ENSMUSP00000113912.2, ENSMUST00000118896.2
    Conserved Domains (1) summary
    pfam04790
    Location:38 → 296
    Sarcoglycan_1; Sarcoglycan complex subunit protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    37984994..39128857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509122.2 → XP_006509185.1  zeta-sarcoglycan isoform X3

    Conserved Domains (1) summary
    pfam04790
    Location:5 → 222
    Sarcoglycan_1; Sarcoglycan complex subunit protein

  2. XM_006509120.5 → XP_006509183.1  zeta-sarcoglycan isoform X1

    See identical proteins and their annotated locations for XP_006509183.1

    UniProtKB/Swiss-Prot
    Q3UVZ2, Q8BX51, Q8K1E7
    UniProtKB/TrEMBL
    Q3SXX6
    Conserved Domains (1) summary
    pfam04790
    Location:38 → 296
    Sarcoglycan_1; Sarcoglycan complex subunit protein

  3. XM_011242138.2 → XP_011240440.1  zeta-sarcoglycan isoform X2

    See identical proteins and their annotated locations for XP_011240440.1

    UniProtKB/TrEMBL
    Q3SXX6
    Conserved Domains (1) summary
    pfam04790
    Location:25 → 283
    Sarcoglycan_1; Sarcoglycan complex subunit protein

  4. XM_011242139.4 → XP_011240441.1  zeta-sarcoglycan isoform X4

    Conserved Domains (1) summary
    pfam04790
    Location:38 → 143
    Sarcoglycan_1; Sarcoglycan complex subunit protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BX51.1 GenPept UniProtKB/Swiss-Prot:Q8BX51

Gene LinkOut

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