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Rgma repulsive guidance molecule family member A [ Mus musculus (house mouse) ]

Gene ID: 244058, updated on 18-Sep-2024

Summary

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Official Symbol
Rgmaprovided by MGI
Official Full Name
repulsive guidance molecule family member Aprovided by MGI
Primary source
MGI:MGI:2679262
See related
Ensembl:ENSMUSG00000070509 AllianceGenome:MGI:2679262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C230063O06
Summary
Enables coreceptor activity and signaling receptor binding activity. Acts upstream of or within several processes, including nervous system development; positive regulation of GTPase activity; and positive regulation of membrane protein ectodomain proteolysis. Located in cell surface. Is expressed in several structures, including future brain; gut; nervous system; sensory organ; and trunk somite. Human ortholog(s) of this gene implicated in multiple sclerosis. Orthologous to human RGMA (repulsive guidance molecule BMP co-receptor a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 24.7), ovary adult (RPKM 23.2) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Rgma in Genome Data Viewer
Location:
7 D1; 7 41.85 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (73025268..73069647)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (73375520..73419899)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_19170 Neighboring gene predicted gene, 30075 Neighboring gene STARR-seq mESC enhancer starr_19173 Neighboring gene RIKEN cDNA 4930429H19 gene Neighboring gene RIKEN cDNA A730056A06 gene Neighboring gene STARR-seq mESC enhancer starr_19176 Neighboring gene predicted gene 44758 Neighboring gene STARR-seq mESC enhancer starr_19180 Neighboring gene STARR-seq mESC enhancer starr_19181 Neighboring gene chromodomain helicase DNA binding protein 2 Neighboring gene STARR-seq mESC enhancer starr_19183 Neighboring gene STARR-seq mESC enhancer starr_19186 Neighboring gene STARR-seq mESC enhancer starr_19187 Neighboring gene STARR-positive B cell enhancer ABC_E6553 Neighboring gene CRISPRi-validated cis-regulatory element for Chaserr and Chd2 Neighboring gene CHD2 adjacent suppressive regulatory RNA Neighboring gene STARR-seq mESC enhancer starr_19190 Neighboring gene STARR-positive B cell enhancer ABC_E1342 Neighboring gene STARR-positive B cell enhancer ABC_E6554 Neighboring gene STARR-seq mESC enhancer starr_19193 Neighboring gene predicted gene, 30149 Neighboring gene predicted gene, 39036

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro. Yuan X, et al. J Lipid Res, 2022 Oct. PMID 36089003, Free PMC Article
  2. Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer. Li Y, et al. Oncogene, 2022 Jan. PMID 34754080
  3. Repulsive Guidance Molecule A Suppresses Adult Neurogenesis. Isaksen TJ, et al. Stem Cell Reports, 2020 Apr 14. PMID 32243839, Free PMC Article
  4. Sympathetic nervous system controls resolution of inflammation via regulation of repulsive guidance molecule A. Körner A, et al. Nat Commun, 2019 Feb 7. PMID 30733433, Free PMC Article
  5. Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis. Tanabe S, et al. Cell Death Dis, 2018 Oct 17. PMID 30333477, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of RGMA improves ischemic stroke via Reprogramming of Neuronal Metabolism.
    Title: Knockdown of RGMA improves ischemic stroke via Reprogramming of Neuronal Metabolism.
  2. RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
    Title: RGMa collapses the neuronal actin barrier against disease-implicated protein and exacerbates ALS.
  3. RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro.
    Title: RGMa promotes dedifferentiation of vascular smooth muscle cells into a macrophage-like phenotype in vivo and in vitro.
  4. RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells.
    Title: RGMa regulates CCL5 expression via the BMP receptor in experimental autoimmune encephalomyelitis mice and endothelial cells.
  5. Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer.
    Title: Aberrant promoter hypermethylation inhibits RGMA expression and contributes to tumor progression in breast cancer.
  6. RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway.
    Title: RGMa can induce skeletal muscle cell hyperplasia via association with neogenin signalling pathway.
  7. Repulsive Guidance Molecule A Suppresses Adult Neurogenesis.
    Title: Repulsive Guidance Molecule A Suppresses Adult Neurogenesis.
  8. Inhibiting Rgma suppresses secondary progression in a mouse model of multiple sclerosis.
    Title: Inhibiting repulsive guidance molecule-a suppresses secondary progression in mouse models of multiple sclerosis.
  9. After chronic morphine injection, Rgma was upregulated in C57BL/6J striatum.
    Title: Genome-wide Association Study Identifies a Regulatory Variant of RGMA Associated With Opioid Dependence in European Americans.
  10. Study focused on the RGMa and RGMb expression in cerebral cortex and hippocampus of newborn mice with maternal lead exposure. RGMa and RGMb expression in hippocampus were upregulated in lead exposed groups, and the RGMa and RGMb expression in cerebral cortex were also higher.
    Title: Effects of maternal lead exposure on RGMa and RGMb expression in the hippocampus and cerebral cortex of mouse pups.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38550, MGC69915

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables coreceptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferrin receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of axon regeneration IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of axon regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of collateral sprouting IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of collateral sprouting ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of receptor binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of BMP signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
repulsive guidance molecule A
Names
RGM domain family, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177740.5 → NP_808408.2  repulsive guidance molecule A precursor

    See identical proteins and their annotated locations for NP_808408.2

    Status: VALIDATED

    Source sequence(s)
    BC059072
    Consensus CDS
    CCDS21362.2
    UniProtKB/Swiss-Prot
    Q6PCX7, Q7TQ34, Q8CIH6
    Related
    ENSMUSP00000091870.6, ENSMUST00000094312.12
    Conserved Domains (2) summary
    pfam06534
    Location:227 → 410
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:48 → 222
    RGM_N; Repulsive guidance molecule (RGM) N-terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    73025268..73069647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540902.2 → XP_006540965.1  repulsive guidance molecule A isoform X1

    See identical proteins and their annotated locations for XP_006540965.1

    UniProtKB/Swiss-Prot
    Q6PCX7
    Related
    ENSMUSP00000145758.2, ENSMUST00000139780.3
    Conserved Domains (2) summary
    pfam06534
    Location:211 → 389
    RGM_C; Repulsive guidance molecule (RGM) C-terminus
    pfam06535
    Location:32 → 206
    RGM_N; Repulsive guidance molecule (RGM) N-terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PCX7.1 GenPept UniProtKB/Swiss-Prot:Q6PCX7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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