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Gfi1 growth factor independent 1 transcriptional repressor [ Rattus norvegicus (Norway rat) ]

Gene ID: 24388, updated on 2-Nov-2024

Summary

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Official Symbol
Gfi1provided by RGD
Official Full Name
growth factor independent 1 transcriptional repressorprovided by RGD
Primary source
RGD:2680
See related
EnsemblRapid:ENSRNOG00000002042 AllianceGenome:RGD:2680
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and enzyme-substrate adaptor activity. Predicted to be involved in several processes, including negative regulation of calcidiol 1-monooxygenase activity; regulation of DNA-templated transcription; and regulation of signal transduction. Predicted to act upstream of or within several processes, including inner ear development; mechanosensory behavior; and regulation of cell fate specification. Predicted to be located in nuclear body and nuclear matrix. Predicted to be part of transcription repressor complex. Human ortholog(s) of this gene implicated in acute myeloid leukemia and severe congenital neutropenia 2. Orthologous to human GFI1 (growth factor independent 1 transcriptional repressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 68.0), Spleen (RPKM 16.0) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Gfi1 in Genome Data Viewer
Location:
14p22
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (2185489..2204191)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (2040576..2056874)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (3058035..3073332)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S26-like Neighboring gene small ribosomal subunit protein eS26-like Neighboring gene ecotropic viral integration site 5 Neighboring gene ubiquitin-conjugating enzyme E2D 2B Neighboring gene RNA polymerase II associated protein 2 Neighboring gene glomulin, FKBP associated protein Neighboring gene similar to human chromosome 1 open reading frame 146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Low GFI1 expression in white blood cells of CP-CML patients at diagnosis is strongly associated with subsequent blastic transformation. Kok CH, et al. Leukemia, 2013 Jun. PMID 23411466
  2. Solution structure of Gfi-1 zinc domain bound to consensus DNA. Lee S, et al. J Mol Biol, 2010 Apr 9. PMID 20153336
  3. Targets of the transcriptional repressor oncoprotein Gfi-1. Duan Z, et al. Proc Natl Acad Sci U S A, 2003 May 13. PMID 12721361, Free PMC Article
  4. High-throughput retroviral tagging for identification of genes involved in initiation and progression of mouse splenic marginal zone lymphomas. Shin MS, et al. Cancer Res, 2004 Jul 1. PMID 15231650
  5. A hypomorphic mutation in the Gfi1 transcriptional repressor results in a novel form of neutropenia. Ordoñez-Rueda D, et al. Eur J Immunol, 2012 Sep. PMID 22684987

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gfi-1 is recruited to CDKN1A core promoter through Miz-1 and represses CDKN1A transcription.
    Title: A role of Miz-1 in Gfi-1-mediated transcriptional repression of CDKN1A.
  2. The structure clearly shows that Gfi-1 zinc fingers 3-5 bind into the major groove of the target DNA reminiscent of canonical C(2)H(2) zinc-finger domains.
    Title: Solution structure of Gfi-1 zinc domain bound to consensus DNA.
  3. This protein targets a subset of genes differentiating hematopoietic lineages and plays a role in the hierarchy of factors governing stem cell differentiation.
    Title: Targets of the transcriptional repressor oncoprotein Gfi-1.
  4. role for auto- and trans-regulation of Gfi1 by GFI1 and GFI1B in maintaining the normal expression patterns of Gfi1
    Title: Targeted transcriptional repression of Gfi1 by GFI1 and GFI1B in lymphoid cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme-substrate adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables enzyme-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme-substrate adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA damage response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within cell fate commitment ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of cell fate specification ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear auditory receptor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within inner ear morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mechanosensory behavior ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of calcidiol 1-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of calcidiol 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of cell fate specification ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell fate specification ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-6-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex IEA
Inferred from Electronic Annotation
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger protein Gfi-1
Names
Growth factor independent-1
growth factor independent 1 transcription repressor
growth factor independent protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012566.2 → NP_036698.1  zinc finger protein Gfi-1

    See identical proteins and their annotated locations for NP_036698.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000014
    UniProtKB/Swiss-Prot
    Q07120
    UniProtKB/TrEMBL
    A6KPI0
    Related
    ENSRNOP00000002807.2, ENSRNOT00000002807.5
    Conserved Domains (3) summary
    COG5048
    Location:255 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:315 → 335
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:355 → 380
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    2185489..2204191
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008769920.4 → XP_008768142.1  zinc finger protein Gfi-1 isoform X2

    Conserved Domains (2) summary
    sd00017
    Location:287 → 307
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:299 → 324
    zf-H2C2_2; Zinc-finger double domain

  2. XM_008769917.4 → XP_008768139.1  zinc finger protein Gfi-1 isoform X1

    See identical proteins and their annotated locations for XP_008768139.1

    UniProtKB/Swiss-Prot
    Q07120
    UniProtKB/TrEMBL
    A6KPI0
    Conserved Domains (3) summary
    COG5048
    Location:255 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:315 → 335
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:355 → 380
    zf-H2C2_2; Zinc-finger double domain

  3. XM_008769918.4 → XP_008768140.1  zinc finger protein Gfi-1 isoform X1

    See identical proteins and their annotated locations for XP_008768140.1

    UniProtKB/Swiss-Prot
    Q07120
    UniProtKB/TrEMBL
    A6KPI0
    Conserved Domains (3) summary
    COG5048
    Location:255 → 417
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:315 → 335
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:355 → 380
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_359278.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q07120.1 GenPept UniProtKB/Swiss-Prot:Q07120

Gene LinkOut

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