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Fuca1 alpha-L-fucosidase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24375, updated on 10-Jul-2024

Summary

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Official Symbol
Fuca1provided by RGD
Official Full Name
alpha-L-fucosidase 1provided by RGD
Primary source
RGD:2636
See related
EnsemblRapid:ENSRNOG00000009325 AllianceGenome:RGD:2636
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fuca
Summary
Enables carbohydrate binding activity and fucosidase activity. Predicted to be involved in fucose metabolic process and glycoside catabolic process. Located in lysosome. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in fucosidosis. Orthologous to human FUCA1 (alpha-L-fucosidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 723.6), Testes (RPKM 474.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Fuca1 in Genome Data Viewer
Location:
5q36
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153436262..153453512)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148152718..148169972)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154269296..154286545)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene cannabinoid receptor 2 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase Neighboring gene UDP-galactose-4-epimerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Alterations of glycosaminoglycan metabolism in the development of diabetic complications in relation to metabolic control. Komosińska-Vassev K, et al. Clin Chem Lab Med, 2005. PMID 16176171
  2. In vitro and in vivo alterations of enzymatic glycosylation in diabetes. Rellier N, et al. Life Sci, 1999. PMID 10353622
  3. Prospective study of the enzymatic activities in urine of N-acetyl-beta-D-glucosaminidase, alpha-D-mannosidase, alpha- and beta-D-glucosidases, alpha-L- and beta-D-fucosidases, and beta-D-galactosidase in type I diabetes mellitus with early nephropathy. Miralles JM, et al. J Diabetes Complications, 1993 Jul-Sep. PMID 8343614
  4. Plasma acidic glycohydrolases in insulin-dependent diabetes mellitus. Kohler E, et al. Acta Diabetol Lat, 1981 Jul-Sep. PMID 7304074
  5. Carbohydrate contents, and glycosidase and glycosyl transferase activities in tissues from streptozotocin diabetic mice. Serrano MA, et al. Comp Biochem Physiol B, 1985. PMID 3924473

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-L-fucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-L-fucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables alpha-L-fucosidase activity ISO
Inferred from Sequence Orthology
more info
  
enables alpha-L-fucosidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables carbohydrate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables fucosidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in fucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fucose metabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glycoside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycoside catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycoside catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycoside catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tissue alpha-L-fucosidase
Names
Fucosidase, alpha-L-1, tissue
alpha-L-fucosidase I
alpha-L-fucoside fucohydrolase 1
fucosidase, alpha-L- 1, tissue
NP_036694.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012562.2 → NP_036694.2  tissue alpha-L-fucosidase precursor

    See identical proteins and their annotated locations for NP_036694.2

    Status: PROVISIONAL

    Source sequence(s)
    BC081844
    UniProtKB/Swiss-Prot
    P17164, Q642C6
    UniProtKB/TrEMBL
    A0A0G2JSJ8, A6IT76
    Related
    ENSRNOP00000012455.3, ENSRNOT00000012455.7
    Conserved Domains (3) summary
    smart00812
    Location:27 → 409
    Alpha_L_fucos; Alpha-L-fucosidase
    COG3669
    Location:59 → 402
    AfuC; Alpha-L-fucosidase [Carbohydrate transport and metabolism]
    pfam16757
    Location:382 → 459
    Fucosidase_C; Alpha-L-fucosidase C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    153436262..153453512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P17164.1 GenPept UniProtKB/Swiss-Prot:P17164

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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