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Adgrd1 adhesion G protein-coupled receptor D1 [ Mus musculus (house mouse) ]

Gene ID: 243277, updated on 2-Nov-2024

Summary

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Official Symbol
Adgrd1provided by MGI
Official Full Name
adhesion G protein-coupled receptor D1provided by MGI
Primary source
MGI:MGI:3041203
See related
Ensembl:ENSMUSG00000044017 AllianceGenome:MGI:3041203
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr133; E230012M21Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in cytosol and nuclear speck. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; foregut; hypothalamus; skeleton; and white fat. Orthologous to human ADGRD1 (adhesion G protein-coupled receptor D1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 23.4), mammary gland adult (RPKM 10.2) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Adgrd1 in Genome Data Viewer
Location:
5 G1.3; 5 67.99 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (129173741..129281663)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (129096750..129204599)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14429 Neighboring gene syntaxin 2 Neighboring gene RAN, member RAS oncogene family Neighboring gene predicted gene, 52830 Neighboring gene predicted gene, 46923 Neighboring gene ribosomal protein S16, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_14430 Neighboring gene STARR-seq mESC enhancer starr_14432 Neighboring gene STARR-seq mESC enhancer starr_14435 Neighboring gene STARR-seq mESC enhancer starr_14441 Neighboring gene STARR-seq mESC enhancer starr_14443 Neighboring gene predicted gene, 34145 Neighboring gene STARR-seq mESC enhancer starr_14450 Neighboring gene predicted gene, 54304

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit. Bianchi E, et al. Nat Commun, 2021 Feb 23. PMID 33623007, Free PMC Article
  2. Cell adhesion receptor GPR133 couples to Gs protein. Bohnekamp J, et al. J Biol Chem, 2011 Dec 9. PMID 22025619, Free PMC Article
  3. The period of the somite segmentation clock is sensitive to Notch activity. Kim W, et al. Mol Biol Cell, 2011 Sep. PMID 21795391, Free PMC Article
  4. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Bjarnadóttir TK, et al. Genomics, 2004 Jul. PMID 15203201
  5. International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors. Hamann J, et al. Pharmacol Rev, 2015. PMID 25713288, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit.
    Title: Control of oviductal fluid flow by the G-protein coupled receptor Adgrd1 is essential for murine embryo transit.
  2. Cell adhesion receptor GPR133 couples to Gs protein
    Title: Cell adhesion receptor GPR133 couples to Gs protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 
  • Targeted (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
adhesion G-protein coupled receptor D1
Names
G protein coupled receptor Gpr133
G-protein coupled receptor PGR25
probable G-protein coupled receptor 133

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081342.1 → NP_001074811.1  adhesion G-protein coupled receptor D1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001074811.1

    Status: VALIDATED

    Source sequence(s)
    AC115899, AC158913
    Consensus CDS
    CCDS39289.1
    UniProtKB/Swiss-Prot
    B2RXC3, Q80T32, Q8BW80
    Related
    ENSMUSP00000060307.8, ENSMUST00000056617.14
    Conserved Domains (3) summary
    pfam01825
    Location:539 → 579
    GPS; GPCR proteolysis site, GPS, motif
    pfam13385
    Location:173 → 273
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cl21561
    Location:595 → 831
    7tm_4; Olfactory receptor

  2. NM_001347486.1 → NP_001334415.1  adhesion G-protein coupled receptor D1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC115899, AC158913
    Consensus CDS
    CCDS84966.1
    UniProtKB/TrEMBL
    B2RXV6
    Related
    ENSMUSP00000121217.3, ENSMUST00000156437.3
    Conserved Domains (4) summary
    smart00303
    Location:505 → 552
    GPS; G-protein-coupled receptor proteolytic site domain
    pfam13385
    Location:167 → 241
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cd14964
    Location:562 → 587
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:560 → 819
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    129173741..129281663
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165131.1 → XP_036021024.1  adhesion G-protein coupled receptor D1 isoform X1

    Conserved Domains (4) summary
    smart00303
    Location:477 → 524
    GPS; G-protein-coupled receptor proteolytic site domain
    pfam13385
    Location:139 → 213
    Laminin_G_3; Concanavalin A-like lectin/glucanases superfamily
    cd14964
    Location:534 → 559
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:532 → 791
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006504308.3 → XP_006504371.1  adhesion G-protein coupled receptor D1 isoform X2

    Conserved Domains (3) summary
    smart00303
    Location:264 → 311
    GPS; G-protein-coupled receptor proteolytic site domain
    cd14964
    Location:321 → 346
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:319 → 578
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177734.2: Suppressed sequence

    Description
    NM_177734.2: This RefSeq was removed because it is thought to be a partial transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80T32.2 GenPept UniProtKB/Swiss-Prot:Q80T32

Gene LinkOut

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