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Tmem132d transmembrane protein 132D [ Mus musculus (house mouse) ]

Gene ID: 243274, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem132dprovided by MGI
Official Full Name
transmembrane protein 132Dprovided by MGI
Primary source
MGI:MGI:3044963
See related
Ensembl:ENSMUSG00000034310 AllianceGenome:MGI:3044963
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C630028F04Rik
Summary
Predicted to be located in membrane. Is expressed in brain and skeleton. Orthologous to human TMEM132D (transmembrane protein 132D). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 4.3), frontal lobe adult (RPKM 3.8) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem132d in Genome Data Viewer
Location:
5 G1.3; 5 66.32 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (127860555..128510141, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (127783491..128433077, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 132C, opposite strand Neighboring gene transmembrane protein 132C Neighboring gene STARR-seq mESC enhancer starr_14401 Neighboring gene STARR-seq mESC enhancer starr_14404 Neighboring gene STARR-seq mESC enhancer starr_14405 Neighboring gene solute carrier family 15, member 4 Neighboring gene STARR-seq mESC enhancer starr_14412 Neighboring gene STARR-seq mESC enhancer starr_14414 Neighboring gene glycosyltransferase 1 domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_14415 Neighboring gene STARR-seq mESC enhancer starr_14419 Neighboring gene STARR-seq mESC enhancer starr_14420 Neighboring gene STARR-seq mESC enhancer starr_14421 Neighboring gene predicted gene, 33738 Neighboring gene predicted gene, 38612

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex. Naik RR, et al. Transl Psychiatry, 2018 Jan 10. PMID 29317594, Free PMC Article
  2. Molecular cloning of a novel transmembrane protein MOLT expressed by mature oligodendrocytes. Nomoto H, et al. J Biochem, 2003 Aug. PMID 12966072
  3. Differential expression of the Tmem132 family genes in the developing mouse nervous system. Wang Y, et al. Gene Expr Patterns, 2022 Sep. PMID 35690356, Free PMC Article
  4. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
  5. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Higher expression of Tmem132d in the anterior cingulate cortex causes increased anxiety-related behavior
    Title: Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 132D
Names
mature OL transmembrane protein
mature oligodendrocytes transmembrane protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172885.2 → NP_766473.1  transmembrane protein 132D precursor

    See identical proteins and their annotated locations for NP_766473.1

    Status: PROVISIONAL

    Source sequence(s)
    AK083210
    Consensus CDS
    CCDS39287.1
    UniProtKB/Swiss-Prot
    A0A0R4J0I2, B2RU39, Q76HP3, Q8C422
    Related
    ENSMUSP00000043633.7, ENSMUST00000044441.8
    Conserved Domains (3) summary
    pfam15705
    Location:49 → 178
    TMEM132D_N; Mature oligodendrocyte transmembrane protein, TMEM132D, N-term
    pfam15706
    Location:884 → 970
    TMEM132D_C; Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
    pfam16070
    Location:435 → 777
    TMEM132; Transmembrane protein family 132

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    127860555..128510141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q76HP3.2 GenPept UniProtKB/Swiss-Prot:Q76HP3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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