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Rab42 RAB42, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 242681, updated on 2-Nov-2024

Summary

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Official Symbol
Rab42provided by MGI
Official Full Name
RAB42, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:2441753
See related
Ensembl:ENSMUSG00000089687 AllianceGenome:MGI:2441753
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab42-ps; 9530096D07Rik
Summary
Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in vesicle-mediated transport. Predicted to be located in membrane. Is expressed in pons mantle layer and rest of cerebellum mantle layer. Orthologous to human RAB42 (RAB42, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 4.0), genital fat pad adult (RPKM 3.6) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Rab42 in Genome Data Viewer
Location:
4 D2.3; 4 65.14 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132027749..132030693, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (132300438..132303382, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene U11 small nuclear RNA Neighboring gene STARR-positive B cell enhancer ABC_E3519 Neighboring gene TATA-box binding protein associated factor 12 Neighboring gene STARR-positive B cell enhancer ABC_E6228 Neighboring gene STARR-positive B cell enhancer ABC_E7994 Neighboring gene small nucleolar RNA, H/ACA box 16A Neighboring gene small nucleolar RNA host gene 12 Neighboring gene small nucleolar RNA, H/ACA box 44

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes. Marubashi S, et al. Cell Struct Funct, 2020 Mar 18. PMID 32037382, Free PMC Article
  2. Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport. Fukuda M, et al. J Biol Chem, 2002 Apr 5. PMID 11856727
  3. The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. Kuroda TS, et al. J Biol Chem, 2002 Mar 15. PMID 11773082
  4. Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2. Fukuda M. J Biol Chem, 2003 Apr 25. PMID 12578829
  5. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes.
    Title: Rab7B/42 Is Functionally Involved in Protein Degradation on Melanosomes in Keratinocytes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-42
Names
RAB42, member RAS oncogene family, pseudogene
putative Ras-related protein Rab-42

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081651.1 → NP_001075120.1  ras-related protein Rab-42

    See identical proteins and their annotated locations for NP_001075120.1

    Status: VALIDATED

    Source sequence(s)
    AL670276
    Consensus CDS
    CCDS38898.1
    UniProtKB/Swiss-Prot
    Q0PD08
    Related
    ENSMUSP00000047735.7, ENSMUST00000040411.7
    Conserved Domains (1) summary
    cl21455
    Location:8 → 215
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    132027749..132030693 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538847.2 → XP_006538910.1  ras-related protein Rab-42 isoform X1

    Conserved Domains (1) summary
    cl38936
    Location:8 → 219
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0PD08.1 GenPept UniProtKB/Swiss-Prot:Q0PD08

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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