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Fyb2 FYN binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 242594, updated on 2-Nov-2024

Summary

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Official Symbol
Fyb2provided by MGI
Official Full Name
FYN binding protein 2provided by MGI
Primary source
MGI:MGI:2685466
See related
Ensembl:ENSMUSG00000078612 AllianceGenome:MGI:2685466
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARAP; Gm620; C1orf168; 1700024P16Rik
Summary
Predicted to be involved in cell adhesion mediated by integrin; cell surface receptor signaling pathway; and protein localization to plasma membrane. Predicted to be located in immunological synapse and membrane raft. Predicted to be active in plasma membrane. Orthologous to human FYB2 (FYN binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in genital fat pad adult (RPKM 1.2), testis adult (RPKM 1.0) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Fyb2 in Genome Data Viewer
Location:
4 C6; 4 48.86 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (104692431..104874061)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (104835301..105016864)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene disabled 1 Neighboring gene predicted gene, 36661 Neighboring gene STARR-seq mESC enhancer starr_10944 Neighboring gene STARR-seq mESC enhancer starr_10945 Neighboring gene STARR-seq mESC enhancer starr_10949 Neighboring gene STARR-seq mESC enhancer starr_10950 Neighboring gene complement component 8, beta polypeptide Neighboring gene predicted gene, 40216 Neighboring gene complement component 8, alpha polypeptide Neighboring gene predicted gene 12721 Neighboring gene VISTA enhancer mm1176 Neighboring gene predicted gene, 52670 Neighboring gene protein kinase, AMP-activated, alpha 2 catalytic subunit Neighboring gene predicted gene, 36893

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
  4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
  5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC169347

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in T cell receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion mediated by integrin ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in immunological synapse ISO
Inferred from Sequence Orthology
more info
  
located_in immunological synapse ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FYN-binding protein 2
Names
activation-dependent, raft-recruited ADAP-like phosphoprotein
uncharacterized protein C1orf168 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162980.2 → NP_001156452.2  FYN-binding protein 2 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AL627186, AL929466
    Consensus CDS
    CCDS51250.2
    UniProtKB/Swiss-Prot
    A2A995
    UniProtKB/TrEMBL
    B2RQ28
    Related
    ENSMUSP00000102416.2, ENSMUST00000106804.2
    Conserved Domains (1) summary
    cl17036
    Location:651 → 723
    SH3; Src Homology 3 domain superfamily

  2. NM_001285952.2 → NP_001272881.2  FYN-binding protein 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL627186, AL929466
    UniProtKB/TrEMBL
    B2RQ28
    Conserved Domains (1) summary
    cl17036
    Location:677 → 749
    SH3; Src Homology 3 domain superfamily

  3. NM_001285953.2 → NP_001272882.1  FYN-binding protein 2 isoform c

    See identical proteins and their annotated locations for NP_001272882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, initiates translation at a downstream in-frame start codon, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AL627186, AL929466
    UniProtKB/TrEMBL
    B2RQ28
    Conserved Domains (1) summary
    cl17036
    Location:624 → 696
    SH3; Src Homology 3 domain superfamily

RNA

  1. NR_104376.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon and uses an alternate splice site in the central region, and includes an additional exon in the 3' region, compared to variant 1. This variant is represented as non-coding because use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL627186, AL929466

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    104692431..104874061
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320219.3 → XP_017175708.1  FYN-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    B2RQ28, E9PZ08
    Conserved Domains (1) summary
    cl17036
    Location:715 → 787
    SH3; Src Homology 3 domain superfamily

  2. XM_006503083.4 → XP_006503146.1  FYN-binding protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006503146.1

    UniProtKB/TrEMBL
    B2RQ28
    Conserved Domains (1) summary
    cl17036
    Location:624 → 696
    SH3; Src Homology 3 domain superfamily

  3. XM_006503085.3 → XP_006503148.1  FYN-binding protein 2 isoform X3

    Conserved Domains (1) summary
    cl17036
    Location:401 → 473
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A995.1 GenPept UniProtKB/Swiss-Prot:A2A995

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