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C6 complement C6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 24237, updated on 2-Nov-2024

Summary

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Official Symbol
C6provided by RGD
Official Full Name
complement C6provided by RGD
Primary source
RGD:2238
See related
EnsemblRapid:ENSRNOG00000024115 AllianceGenome:RGD:2238
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in positive regulation of apoptotic process. Located in extracellular space. Used to study end stage renal disease; glomerulonephritis; and proteinuria. Human ortholog(s) of this gene implicated in complement component 6 deficiency. Orthologous to human C6 (complement C6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Liver (RPKM 978.1) and Lung (RPKM 85.9) See more
Orthologs
human mouse all
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Genomic context

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Location:
2q16
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (55573596..55648857)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (53846028..53921279)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (54460333..54533801)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 3 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene septin 7, pseudogene 2 Neighboring gene maestro heat-like repeat family member 2B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of C5 or absence of C6 protects from sepsis mortality. Buras JA, et al. Immunobiology, 2004. PMID 15638131
  2. Depletion of C6 prevents development of proteinuria in experimental membranous nephropathy in rats. Baker PJ, et al. Am J Pathol, 1989 Jul. PMID 2672823, Free PMC Article
  3. Hepatic and extrahepatic biosynthesis of complement factor C6 in the rat. Brauer RB, et al. J Immunol, 1994 Oct 1. PMID 8089494
  4. C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. Nangaku M, et al. J Am Soc Nephrol, 2002 Apr. PMID 11912252
  5. Attenuation of experimental allergic encephalomyelitis in complement component 6-deficient rats is associated with reduced complement C9 deposition, P-selectin expression, and cellular infiltrate in spinal cords. Tran GT, et al. J Immunol, 2002 May 1. PMID 11970970

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Findings suggest that C6 deficiency by itself does not alter the regrowth capacity of the peripheral nerve after crush injury.
    Title: C6 deficiency does not alter intrinsic regeneration speed after peripheral nerve crush injury.
  2. The present study thus defines a novel role for ASK1 as a mediator of C5b-9-dependent cell injury.
    Title: Role of apoptosis signal-regulating kinase 1 in complement-mediated glomerular epithelial cell injury.
  3. C6 deficiency did not lead to neuroprotection after status epilepticus
    Title: Complement protein 6 deficiency in PVG/c rats does not lead to neuroprotection against seizure induced cell death.
  4. Pathology showed improved nerve regeneration in tibials of C6 deficient animals compared to wildtypes.
    Title: Complement inhibition accelerates regeneration in a model of peripheral nerve injury.
  5. essential in the mechanism of hepatic ischemia/reperfusion injury
    Title: The membrane attack complex (C5b-9) in liver cold ischemia and reperfusion injury.
  6. This study demonstrates that complement component 6 is not essential for the development of proteinuria in passive Heymann nephritis.
    Title: Induction of passive Heymann nephritis in complement component 6-deficient PVG rats.
  7. The membrane attack complex of complement induces caspase activation and apoptosis.
    Title: The membrane attack complex of complement induces caspase activation and apoptosis.
  8. Lung allografts from C6-deficient donors to C6(-) recipients survive 13-17 days, whereas allografts from C6-sufficient donors to C6(+) recipients are rejected with intense vascular infiltration and diffuse alveolar hemorrhage 7 days posttransplant.
    Title: Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in complement activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in complement activation ISO
Inferred from Sequence Orthology
more info
  
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of activation of membrane attack complex ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of complement activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
part_of membrane attack complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of membrane attack complex IEA
Inferred from Electronic Annotation
more info
  
part_of membrane attack complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement component C6
Names
complement component 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176074.4 → NP_788263.2  complement component C6 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q811M5
    UniProtKB/TrEMBL
    F1M7F7
    Conserved Domains (8) summary
    cd00033
    Location:644 → 700
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02831
    Location:644 → 764
    PHA02831; EEV host range protein; Provisional
    smart00209
    Location:568 → 612
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:292 → 514
    MACPF; MAC/Perforin domain
    pfam19028
    Location:28 → 78
    TSP1_spondin; Spondin-like TSP1 domain
    cl15278
    Location:85 → 128
    TSP_1; Thrombospondin type 1 domain
    cl20168
    Location:862 → 934
    Kazal_3; Kazal-type serine protease inhibitor domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    55573596..55648857
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760747.4 → XP_008758969.2  complement component C6 isoform X1

    UniProtKB/Swiss-Prot
    Q811M5
    UniProtKB/TrEMBL
    F1M7F7
    Related
    ENSRNOP00000029891.5, ENSRNOT00000033112.6
    Conserved Domains (8) summary
    cd00033
    Location:644 → 700
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    PHA02831
    Location:644 → 764
    PHA02831; EEV host range protein; Provisional
    smart00209
    Location:568 → 612
    TSP1; Thrombospondin type 1 repeats
    cd00112
    Location:142 → 173
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01823
    Location:292 → 514
    MACPF; MAC/Perforin domain
    pfam19028
    Location:28 → 78
    TSP1_spondin; Spondin-like TSP1 domain
    cl15278
    Location:85 → 128
    TSP_1; Thrombospondin type 1 domain
    cl20168
    Location:862 → 934
    Kazal_3; Kazal-type serine protease inhibitor domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q811M5.1 GenPept UniProtKB/Swiss-Prot:Q811M5

Gene LinkOut

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