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Vtcn1 V-set domain containing T cell activation inhibitor 1 [ Mus musculus (house mouse) ]

Gene ID: 242122, updated on 2-Nov-2024

Summary

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Official Symbol
Vtcn1provided by MGI
Official Full Name
V-set domain containing T cell activation inhibitor 1provided by MGI
Primary source
MGI:MGI:3039619
See related
Ensembl:ENSMUSG00000051076 AllianceGenome:MGI:3039619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B7x; B7h4; B7s1
Summary
Enables signaling receptor binding activity. Acts upstream of or within positive regulation of interleukin-2 production; regulation of T cell activation; and response to protozoan. Located in external side of plasma membrane. Is expressed in several structures, including hemolymphoid system gland; liver; lung; male reproductive gland or organ; and pancreas. Orthologous to human VTCN1 (V-set domain containing T cell activation inhibitor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in subcutaneous fat pad adult (RPKM 4.1), mammary gland adult (RPKM 2.4) and 9 other tissues See more
Orthologs
human all
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Genomic context

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See Vtcn1 in Genome Data Viewer
Location:
3 F2.2; 3 43.78 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100732775..100805555)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (100825459..100896922)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_08498 Neighboring gene STARR-positive B cell enhancer ABC_E3455 Neighboring gene predicted gene 43464 Neighboring gene STARR-seq mESC enhancer starr_08501 Neighboring gene predicted gene, 40107 Neighboring gene predicted gene, 32720 Neighboring gene STARR-positive B cell enhancer ABC_E232 Neighboring gene predicted gene, 40108 Neighboring gene tripartite motif-containing 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. B7-H4 mediates inhibition of T cell responses by activated murine hepatic stellate cells. Chinnadurai R, et al. Hepatology, 2010 Dec. PMID 21064155, Free PMC Article
  2. Endogenous expression of B7-H4 improves long-term murine islet allograft survival. Wang X, et al. Transplantation, 2013 Jan 15. PMID 23192157
  3. Induced expression of B7-H4 on the surface of lung cancer cell by the tumor-associated macrophages: a potential mechanism of immune escape. Chen C, et al. Cancer Lett, 2012 Apr 1. PMID 22108530
  4. B7x/B7-H4 modulates the adaptive immune response and ameliorates renal injury in antibody-mediated nephritis. Pawar RD, et al. Clin Exp Immunol, 2015 Feb. PMID 25205493, Free PMC Article
  5. Overexpression of B7-H4 in tumor infiltrated dendritic cells. Cheng C, et al. J Immunoassay Immunochem, 2011. PMID 21728826

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression.
    Title: A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression.
  2. Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
    Title: Effect of B7-H4 downregulation induced by Toxoplasma gondii infection on dysfunction of decidual macrophages contributes to adverse pregnancy outcomes.
  3. B7-H4 reduction induced by Toxoplasma gondii infection results in dysfunction of decidual dendritic cells by regulating the JAK2/STAT3 pathway.
    Title: B7-H4 reduction induced by Toxoplasma gondii infection results in dysfunction of decidual dendritic cells by regulating the JAK2/STAT3 pathway.
  4. Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
    Title: Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer.
  5. The B7-H4 gene induces immune escape partly via upregulating the PD-1/Stat3 pathway in non-small cell lung cancer.
    Title: The B7-H4 gene induces immune escape partly via upregulating the PD-1/Stat3 pathway in non-small cell lung cancer.
  6. Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality.
    Title: Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality.
  7. study presents first evidence that B7-H4 acts as a tumor suppressor through PTEN/AKT/HIF-1alpha/RCOR2/RUNX1 pathways to promote the differentiation of leukemia-initiating cells but does not impair the normal functions of hematopoietic stem cells
    Title: B7-H4 enhances the differentiation of murine leukemia-initiating cells via the PTEN/AKT/RCOR2/RUNX1 pathways.
  8. B7S1 initiates dysfunction of tumor-infiltrating CD8+ T cells and may be targeted for cancer immunotherapy.
    Title: Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8(+) T Cells.
  9. this study shows that B7-H4 knockout hosts mount greater tumor-associated anti-tumor T cell responses and display reduced tumors
    Title: Synergistic effects of host B7-H4 deficiency and gemcitabine treatment on tumor regression and anti-tumor T cell immunity in a mouse model.
  10. Results highlight an importance of VTCN1 stabilization on cell surfaces for the restoration of altered balance of immune control during T1D.
    Title: Loss of Peripheral Protection in Pancreatic Islets by Proteolysis-Driven Impairment of VTCN1 (B7-H4) Presentation Is Associated with the Development of Autoimmune Diabetes.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (9) 
  • Targeted (6)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC41287

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables signaling receptor binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within interleukin-4 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of T cell activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of interleukin-2 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to protozoan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
V-set domain containing T-cell activation inhibitor 1
Names
B7 homolog 4
immune costimulatory protein B7-H4
t cell costimulatory molecule B7x

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001409755.1 → NP_001396684.1  V-set domain containing T-cell activation inhibitor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669872, AL691436

  2. NM_001409758.1 → NP_001396687.1  V-set domain containing T-cell activation inhibitor 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669872

  3. NM_178594.4 → NP_848709.2  V-set domain containing T-cell activation inhibitor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_848709.2

    Status: VALIDATED

    Source sequence(s)
    AL669872, AL691436
    Consensus CDS
    CCDS17677.1
    UniProtKB/Swiss-Prot
    Q7TPH5, Q7TSP5, Q8K091
    Related
    ENSMUSP00000057721.8, ENSMUST00000054791.9
    Conserved Domains (2) summary
    smart00410
    Location:46 → 144
    IG_like; Immunoglobulin like
    cl11960
    Location:49 → 146
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    100732775..100805555
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TSP5.1 GenPept UniProtKB/Swiss-Prot:Q7TSP5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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