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CLDN15 claudin 15 [ Homo sapiens (human) ]

Gene ID: 24146, updated on 5-Mar-2024

Summary

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Official Symbol
CLDN15provided by HGNC
Official Full Name
claudin 15provided by HGNC
Primary source
HGNC:HGNC:2036
See related
Ensembl:ENSG00000106404 MIM:615778; AllianceGenome:HGNC:2036
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in duodenum (RPKM 65.8), small intestine (RPKM 50.2) and 8 other tissues See more
Orthologs
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Genomic context

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Location:
7q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (101232094..101238820, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (102555557..102562283, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (100875375..100882101, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100859968-100860490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18481 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100861252-100861793 Neighboring gene zinc finger HIT-type containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100870334-100870510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100874831-100875752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:100883201-100883744 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26402 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26403 Neighboring gene fission, mitochondrial 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:100893889-100894842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18482 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:100909266-100909443 Neighboring gene RNA, U6 small nuclear 1104, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues. Hempel C, et al. Ann N Y Acad Sci, 2022 Sep. PMID 35650657
  2. A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations. Alberini G, et al. PLoS One, 2017. PMID 28863193, Free PMC Article
  3. Effect of claudin expression on paracellular permeability, migration and invasion of colonic cancer cells. Takehara M, et al. Biol Pharm Bull, 2009 May. PMID 19420749
  4. Claudins--key pieces in the tight junction puzzle. Koval M. Cell Commun Adhes, 2006 May-Jun. PMID 16798613
  5. Claudins create charge-selective channels in the paracellular pathway between epithelial cells. Colegio OR, et al. Am J Physiol Cell Physiol, 2002 Jul. PMID 12055082

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unique structural features of claudin-5 and claudin-15 lead to functionally distinct tight junction strand architecture.
    Title: Unique structural features of claudin-5 and claudin-15 lead to functionally distinct tight junction strand architecture.
  2. Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues.
    Title: Tight junction channels claudin-10b and claudin-15: Functional mapping of pore-lining residues.
  3. CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma.
    Title: CLDN15 is a novel diagnostic marker for malignant pleural mesothelioma.
  4. Twist1 accelerates tumour vasculogenic mimicry by inhibiting Claudin15 expression in triple-negative breast cancer.
    Title: Twist1 accelerates tumour vasculogenic mimicry by inhibiting Claudin15 expression in triple-negative breast cancer.
  5. Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease.
    Title: Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease.
  6. analysis of claudin-15 tight junction paracellular architecture by molecular dynamics simulations
    Title: A refined model of claudin-15 tight junction paracellular architecture by molecular dynamics simulations.
  7. Data show that alterations in myosin light chain kinase activity, claudin-15 and claudin-2 expression are associated with gluten-induced symptomatology and intestinal permeability changes in diarrhea-predominant irritable bowel syndrome (IBS-D).
    Title: Gluten-induced symptoms in diarrhea-predominant irritable bowel syndrome are associated with increased myosin light chain kinase activity and claudin-15 expression.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Impact of ancestry and common genetic variants on QT interval in African Americans.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42715, MGC19536

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables identical protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
claudin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001185080.2 → NP_001172009.1  claudin-15

    See identical proteins and their annotated locations for NP_001172009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK056103, DB158141
    Consensus CDS
    CCDS5717.1
    UniProtKB/Swiss-Prot
    B3KPB5, P56746
    Related
    ENSP00000385300.1, ENST00000401528.5
    Conserved Domains (1) summary
    cl21598
    Location:3 → 177
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. NM_014343.3 → NP_055158.1  claudin-15

    See identical proteins and their annotated locations for NP_055158.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a shorter and alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AJ245738, AK056103
    Consensus CDS
    CCDS5717.1
    UniProtKB/Swiss-Prot
    B3KPB5, P56746
    Related
    ENSP00000308870.5, ENST00000308344.10
    Conserved Domains (1) summary
    cl21598
    Location:3 → 177
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    101232094..101238820 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    102555557..102562283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_138429.1: Suppressed sequence

    Description
    NM_138429.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P56746.1 GenPept UniProtKB/Swiss-Prot:P56746

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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