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Tekt2 tektin 2 [ Mus musculus (house mouse) ]

Gene ID: 24084, updated on 2-Nov-2024

Summary

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Official Symbol
Tekt2provided by MGI
Official Full Name
tektin 2provided by MGI
Primary source
MGI:MGI:1346335
See related
Ensembl:ENSMUSG00000028845 AllianceGenome:MGI:1346335
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
tektin-t
Summary
Involved in flagellated sperm motility. Acts upstream of or within inner dynein arm assembly. Located in microtubule organizing center. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in foregut-midgut junction and inner ear. Orthologous to human TEKT2 (tektin 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 147.5) and limb E14.5 (RPKM 8.4) See more
Orthologs
human all
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Genomic context

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See Tekt2 in Genome Data Viewer
Location:
4 D2.2; 4 60.37 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126215914..126219481, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126322121..126325688, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene collagen, type VIII, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:125998967-125999150 Neighboring gene ADP-ribosylserine hydrolase Neighboring gene STARR-seq mESC enhancer starr_11400 Neighboring gene argonaute RISC catalytic subunit 3 Neighboring gene STARR-seq mESC enhancer starr_11401 Neighboring gene STARR-positive B cell enhancer ABC_E7988 Neighboring gene argonaute RISC catalytic subunit 1 Neighboring gene STARR-seq mESC enhancer starr_11403 Neighboring gene STARR-positive B cell enhancer ABC_E2714

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning of haploid germ cell-specific tektin cDNA and analysis of the protein in mouse testis. Iguchi N, et al. FEBS Lett, 1999 Aug 6. PMID 10456331
  2. Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis. Durcan TM, et al. J Cell Biol, 2008 May 19. PMID 18474621, Free PMC Article
  3. Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function. Tanaka H, et al. Mol Cell Biol, 2004 Sep. PMID 15340058, Free PMC Article
  4. Tektin 4 is located on outer dense fibers, not associated with axonemal tubulins of flagella in rodent spermatozoa. Iida H, et al. Mol Reprod Dev, 2006 Jul. PMID 16596631
  5. Molecular cloning of mXCR1, the murine SCM-1/lymphotactin receptor. Yoshida T, et al. FEBS Lett, 1999 Sep 10. PMID 10518929

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tek2-dependent organization of the central spindle during anaphase is essential for proper midbody formation and the segregation of daughter cells after cytokinesis.
    Title: Tektin 2 is required for central spindle microtubule organization and the completion of cytokinesis.
  2. Tektin-t participates in dynein inner arm formation or attachment and that the loss of Tektin-t results in impaired motility of both flagella and cilia.
    Title: Mice deficient in the axonemal protein Tektin-t exhibit male infertility and immotile-cilium syndrome due to impaired inner arm dynein function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement involved in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in flagellated sperm motility IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inner dynein arm assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axonemal A tubule inner sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axonemal microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in axonemal microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule organizing center IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tektin-2
Names
testicular tektin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357262.1 → NP_001344191.1  tektin-2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AK006205, AL606976, BG083070, BY084876, BY094167
    Consensus CDS
    CCDS18651.1
    UniProtKB/Swiss-Prot
    Q922G7, Q9WVR0
    Related
    ENSMUSP00000099676.2, ENSMUST00000102616.8
    Conserved Domains (1) summary
    pfam03148
    Location:17 → 395
    Tektin; Tektin family

  2. NM_001357263.1 → NP_001344192.1  tektin-2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AK006205, AL606976, BB603783, BG083070, BY084876, BY094167
    Consensus CDS
    CCDS18651.1
    UniProtKB/Swiss-Prot
    Q922G7, Q9WVR0
    Conserved Domains (1) summary
    pfam03148
    Location:17 → 395
    Tektin; Tektin family

  3. NM_011902.3 → NP_036032.2  tektin-2

    See identical proteins and their annotated locations for NP_036032.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) reprsents the longest transcript. Variants 1-3 all encode the same protein.
    Source sequence(s)
    AK006205, AL606976, BG083070, BY084876, BY094167
    Consensus CDS
    CCDS18651.1
    UniProtKB/Swiss-Prot
    Q922G7, Q9WVR0
    Conserved Domains (1) summary
    pfam03148
    Location:17 → 395
    Tektin; Tektin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    126215914..126219481 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922G7.1 GenPept UniProtKB/Swiss-Prot:Q922G7

Gene LinkOut

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