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Slc35a1 solute carrier family 35 (CMP-sialic acid transporter), member 1 [ Mus musculus (house mouse) ]

Gene ID: 24060, updated on 5-Nov-2024

Summary

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Official Symbol
Slc35a1provided by MGI
Official Full Name
solute carrier family 35 (CMP-sialic acid transporter), member 1provided by MGI
Primary source
MGI:MGI:1345622
See related
Ensembl:ENSMUSG00000028293 AllianceGenome:MGI:1345622
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CST; CMP-SA-Tr; CMP-Sia-Tr
Summary
Enables CMP-N-acetylneuraminate transmembrane transporter activity and antiporter activity. Involved in CMP-N-acetylneuraminate biosynthetic process and CMP-N-acetylneuraminate transmembrane transport. Located in Golgi membrane. Is expressed in several structures, including genitourinary system; liver; lung; retina; and spleen. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIf. Orthologous to human SLC35A1 (solute carrier family 35 member A1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 7.9), bladder adult (RPKM 4.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Slc35a1 in Genome Data Viewer
Location:
4 A5; 4 16.86 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (34663257..34688113, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (34663257..34688113, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:34497692-34497879 Neighboring gene akirin 2 Neighboring gene STARR-seq mESC enhancer starr_09912 Neighboring gene origin recognition complex, subunit 3 Neighboring gene arginyl-tRNA synthetase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E6160 Neighboring gene cilia and flagella associated protein 206 Neighboring gene STARR-seq mESC enhancer starr_09914 Neighboring gene STARR-seq mESC enhancer starr_09915 Neighboring gene predicted gene 136

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Endothelial Slc35a1 Deficiency Causes Loss of LSEC Identity and Exacerbates Neonatal Lipid Deposition in the Liver in Mice. Zuo B, et al. Cell Mol Gastroenterol Hepatol, 2024. PMID 38467191, Free PMC Article
  2. Membrane topology of the mammalian CMP-sialic acid transporter. Eckhardt M, et al. J Biol Chem, 1999 Mar 26. PMID 10085119
  3. Targeting the expression of functional murine CMP-sialic acid transporter to the E. coli inner membrane. Maggioni A, et al. Biochem Biophys Res Commun, 2007 Oct 26. PMID 17764658
  4. The promiscuous binding pocket of SLC35A1 ensures redundant transport of CDP-ribitol to the Golgi. Ury B, et al. J Biol Chem, 2021 Jan-Jun. PMID 34015330, Free PMC Article
  5. Expression cloning of the Golgi CMP-sialic acid transporter. Eckhardt M, et al. Proc Natl Acad Sci U S A, 1996 Jul 23. PMID 8755516, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial Slc35a1 Deficiency Causes Loss of LSEC Identity and Exacerbates Neonatal Lipid Deposition in the Liver in Mice.
    Title: Endothelial Slc35a1 Deficiency Causes Loss of LSEC Identity and Exacerbates Neonatal Lipid Deposition in the Liver in Mice.
  2. Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase and Solute Carrier Family 35 Member A1 Are Required for Reovirus Binding and Infection.
    Title: Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase and Solute Carrier Family 35 Member A1 Are Required for Reovirus Binding and Infection.
  3. Detailed visualization of extensive protein-substrate interactions explains the mechanisms governing substrate selectivity. Further structural analysis of mCST's unique lumen-facing partially-occluded conformation, coupled with the characterization of substrate-induced quenching of mCST's intrinsic tryptophan fluorescence, reveals the concerted conformational transitions that occur during substrate transport.
    Title: Structural basis for mammalian nucleotide sugar transport.
  4. analysis of the functional murine CMP-sialic acid transporter expressed in the E. coli inner membrane
    Title: Targeting the expression of functional murine CMP-sialic acid transporter to the E. coli inner membrane.
  5. CMP-sialic acid transporter is localized in the medial-trans Golgi
    Title: The CMP-sialic acid transporter is localized in the medial-trans Golgi and possesses two specific endoplasmic reticulum export motifs in its carboxyl-terminal cytoplasmic tail.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CMP-N-acetylneuraminate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables CMP-N-acetylneuraminate transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CMP-N-acetylneuraminate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in CMP-N-acetylneuraminate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CMP-N-acetylneuraminate transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CMP-N-acetylneuraminate transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
CMP-sialic acid transporter
Names
solute carrier family 35 member A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424928.1 → NP_001411857.1  CMP-sialic acid transporter isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL928738

  2. NM_001424930.1 → NP_001411859.1  CMP-sialic acid transporter isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL928738

  3. NM_001424931.1 → NP_001411860.1  CMP-sialic acid transporter isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL928738

  4. NM_001424932.1 → NP_001411861.1  CMP-sialic acid transporter isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL928738

  5. NM_001424933.1 → NP_001411862.1  CMP-sialic acid transporter isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL928738

  6. NM_011895.4 → NP_036025.2  CMP-sialic acid transporter isoform 3

    See identical proteins and their annotated locations for NP_036025.2

    Status: VALIDATED

    Source sequence(s)
    AL928738
    Consensus CDS
    CCDS18030.1
    UniProtKB/Swiss-Prot
    A2AT44, Q61420
    Related
    ENSMUSP00000029970.8, ENSMUST00000029970.14
    Conserved Domains (1) summary
    pfam04142
    Location:8 → 314
    Nuc_sug_transp; Nucleotide-sugar transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    34663257..34688113 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537892.4 → XP_006537955.1  CMP-sialic acid transporter isoform X2

    Conserved Domains (1) summary
    pfam04142
    Location:8 → 335
    Nuc_sug_transp; Nucleotide-sugar transporter

RNA

  1. XR_001784138.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61420.2 GenPept UniProtKB/Swiss-Prot:Q61420

Gene LinkOut

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