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Cdc42bpg CDC42 binding protein kinase gamma [ Mus musculus (house mouse) ]

Gene ID: 240505, updated on 2-Nov-2024

Summary

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Official Symbol
Cdc42bpgprovided by MGI
Official Full Name
CDC42 binding protein kinase gammaprovided by MGI
Primary source
MGI:MGI:2652845
See related
Ensembl:ENSMUSG00000024769 AllianceGenome:MGI:2652845
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRCKgamma
Summary
Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in actomyosin structure organization and protein phosphorylation. Predicted to be located in cell leading edge; centriolar satellite; and cytosol. Predicted to be active in cytoplasm and cytoskeleton. Orthologous to human CDC42BPG (CDC42 binding protein kinase gamma). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in lung adult (RPKM 55.3), colon adult (RPKM 31.8) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Cdc42bpg in Genome Data Viewer
Location:
19 A; 19 4.43 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6356465..6375682)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6306253..6325653)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene 14963 Neighboring gene STARR-positive B cell enhancer ABC_E8732 Neighboring gene EH-domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_45427 Neighboring gene predicted gene, 52380 Neighboring gene STARR-positive B cell enhancer ABC_E5682 Neighboring gene STARR-positive B cell enhancer ABC_E11670 Neighboring gene STARR-positive B cell enhancer ABC_E3239 Neighboring gene STARR-positive B cell enhancer ABC_E11015 Neighboring gene multiple endocrine neoplasia 1 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 2 Neighboring gene microRNA 6989

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model. Kwa MQ, et al. Cells, 2021 Apr 19. PMID 33921698, Free PMC Article
  2. Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse. Selimi F, et al. PLoS Biol, 2009 Apr 14. PMID 19402746, Free PMC Article
  3. Rebalancing gene haploinsufficiency in vivo by targeting chromatin. Fulcoli FG, et al. Nat Commun, 2016 Jun 3. PMID 27256596, Free PMC Article
  4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
  5. The central role of EED in the orchestration of polycomb group complexes. Cao Q, et al. Nat Commun, 2014. PMID 24457600, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MRCKalpha Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
    Title: MRCKα Is Dispensable for Breast Cancer Development in the MMTV-PyMT Model.
  2. MRCKgamma can modulate maturation of dendritic spines in cultured cortical neurons, and it is localized specifically to parallel fiber/Purkinje cell synapses in vivo.
    Title: Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell leading edge ISO
Inferred from Sequence Orthology
more info
  
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase MRCK gamma
Names
CDC42 binding protein kinase gamma (DMPK-like)
DMPK-like gamma
MRCK gamma
myotonic dystrophy kinase-related CDC42-binding kinase gamma
myotonic dystrophy protein kinase-like alpha
myotonic dystrophy protein kinase-like gamma
NP_001028514.1
XP_036017481.1
XP_036017482.1
XP_036017483.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033342.1 → NP_001028514.1  serine/threonine-protein kinase MRCK gamma

    See identical proteins and their annotated locations for NP_001028514.1

    Status: VALIDATED

    Source sequence(s)
    AC127556
    Consensus CDS
    CCDS50365.1
    UniProtKB/Swiss-Prot
    Q80UW5
    Related
    ENSMUSP00000025681.8, ENSMUST00000025681.8
    Conserved Domains (7) summary
    pfam08826
    Location:743 → 798
    DMPK_coil; DMPK coiled coil domain like
    smart00220
    Location:71 → 337
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01243
    Location:937 → 1069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    pfam00130
    Location:878 → 926
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam00780
    Location:1096 → 1359
    CNH; CNH domain
    pfam09728
    Location:452 → 774
    Taxilin; Myosin-like coiled-coil protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6356465..6375682
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161588.1 → XP_036017481.1  serine/threonine-protein kinase MRCK gamma isoform X1

    Conserved Domains (5) summary
    cd01243
    Location:937 → 1069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:444 → 802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00780
    Location:1096 → 1359
    CNH; CNH domain
    cd20866
    Location:878 → 929
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

  2. XM_036161589.1 → XP_036017482.1  serine/threonine-protein kinase MRCK gamma isoform X2

    Conserved Domains (5) summary
    cd01243
    Location:936 → 1068
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:444 → 802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00780
    Location:1095 → 1358
    CNH; CNH domain
    cd20866
    Location:877 → 928
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins

  3. XM_036161590.1 → XP_036017483.1  serine/threonine-protein kinase MRCK gamma isoform X3

    Conserved Domains (4) summary
    cd01243
    Location:937 → 1069
    PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
    cd05597
    Location:69 → 399
    STKc_DMPK_like; Catalytic domain of Myotonic Dystrophy protein kinase (DMPK)-like Serine/Threonine Kinases
    TIGR02168
    Location:444 → 802
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cd20866
    Location:878 → 929
    C1_MRCKgamma; protein kinase C conserved region 1 (C1 domain) found in myotonic dystrophy kinase-related Cdc42-binding kinase gamma (MRCK gamma) and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UW5.2 GenPept UniProtKB/Swiss-Prot:Q80UW5

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