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Septin3 septin 3 [ Mus musculus (house mouse) ]

Gene ID: 24050, updated on 2-Nov-2024

Summary

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Official Symbol
Septin3provided by MGI
Official Full Name
septin 3provided by MGI
Primary source
MGI:MGI:1345148
See related
Ensembl:ENSMUSG00000022456 AllianceGenome:MGI:1345148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sep3; Sept3; Gm46500; 3110018K01Rik; B530002E20Rik
Summary
Predicted to enable several functions, including GTP binding activity; GTPase activity; and identical protein binding activity. Involved in protein catabolic process at presynapse. Part of septin complex. Is active in presynapse. Is expressed in several structures, including central nervous system; peripheral nervous system ganglion; sensory organ; somite; and testis. Orthologous to human SEPTIN3 (septin 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E14 (RPKM 82.2), whole brain E14.5 (RPKM 81.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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See Septin3 in Genome Data Viewer
Location:
15 E1; 15 38.56 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (82153003..82178775)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (82268802..82294574)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene centromere protein M Neighboring gene STARR-positive B cell enhancer ABC_E8601 Neighboring gene STARR-seq mESC enhancer starr_39290 Neighboring gene small integral membrane protein 45 Neighboring gene predicted gene, 52180 Neighboring gene STARR-seq mESC enhancer starr_39292 Neighboring gene WBP2 N-terminal like Neighboring gene N-acetyl galactosaminidase, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons. Fujishima K, et al. J Neurochem, 2007 Jul. PMID 17564677
  2. Retroviral promoter-trap insertion into a novel mammalian septin gene expressed during mouse neuronal development. Xiong JW, et al. Mech Dev, 1999 Aug. PMID 10446280
  3. Large-scale screening for developmental genes in embryonic stem cells and embryoid bodies using retroviral entrapment vectors. Xiong JW, et al. Dev Dyn, 1998 Jun. PMID 9626494
  4. Neuronal-specific septin-3 binds Atg8/LC3B, accumulates and localizes to autophagosomes during induced autophagy. Tóth V, et al. Cell Mol Life Sci, 2022 Aug 6. PMID 35932293, Free PMC Article
  5. Tnfrsf13c (Baffr) is mis-expressed in tumors with murine leukemia virus insertions at Lvis22. Hentges KE, et al. Genomics, 2002 Aug. PMID 12160734

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEPT3 and SEPT5 are dispensable for neuronal development as well as for synaptic vesicle fusion and recycling.
    Title: Superfluous role of mammalian septins 3 and 5 in neuronal development and synaptic transmission.
  2. Sept3 is dispensable for normal neuronal development
    Title: Targeted disruption of Sept3, a heteromeric assembly partner of Sept5 and Sept7 in axons, has no effect on developing CNS neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein catabolic process at presynapse EXP
Inferred from Experiment
more info
 PubMed 
involved_in protein catabolic process at presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein catabolic process at presynapse IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein catabolic process at presynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
neuronal-specific septin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358836.2 → NP_001345765.1  neuronal-specific septin-3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Conserved Domains (1) summary
    cd01850
    Location:59 → 333
    CDC_Septin; CDC/Septin GTPase family

  2. NM_001358837.2 → NP_001345766.1  neuronal-specific septin-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Conserved Domains (1) summary
    cd01850
    Location:59 → 333
    CDC_Septin; CDC/Septin GTPase family

  3. NM_001368642.1 → NP_001355571.1  neuronal-specific septin-3 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC104325
    UniProtKB/Swiss-Prot
    Q3TNZ2, Q7TNT7, Q9Z1S5
    Conserved Domains (1) summary
    cd01850
    Location:59 → 333
    CDC_Septin; CDC/Septin GTPase family

  4. NM_001368643.1 → NP_001355572.1  neuronal-specific septin-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Conserved Domains (1) summary
    cd01850
    Location:59 → 332
    CDC_Septin; CDC/Septin GTPase family

  5. NM_001368644.1 → NP_001355573.1  neuronal-specific septin-3 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Conserved Domains (1) summary
    cd01850
    Location:46 → 320
    CDC_Septin; CDC/Septin GTPase family

  6. NM_001368645.1 → NP_001355574.1  neuronal-specific septin-3 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Consensus CDS
    CCDS88814.1
    UniProtKB/TrEMBL
    A0A2R8W6V9
    Related
    ENSMUSP00000155480.2, ENSMUST00000230365.2
    Conserved Domains (1) summary
    cd01850
    Location:46 → 320
    CDC_Septin; CDC/Septin GTPase family

  7. NM_001368646.1 → NP_001355575.1  neuronal-specific septin-3 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Conserved Domains (1) summary
    cd01850
    Location:46 → 319
    CDC_Septin; CDC/Septin GTPase family

  8. NM_001368647.1 → NP_001355576.1  neuronal-specific septin-3 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Conserved Domains (1) summary
    cd01850
    Location:4 → 269
    CDC_Septin; CDC/Septin GTPase family

  9. NM_001368784.1 → NP_001355713.1  neuronal-specific septin-3 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Consensus CDS
    CCDS88813.1
    UniProtKB/TrEMBL
    A0A5F8MPL6
    Related
    ENSMUSP00000158860.2, ENSMUST00000239048.2
    Conserved Domains (1) summary
    cd01850
    Location:527 → 801
    CDC_Septin; CDC/Septin GTPase family

  10. NM_001368785.1 → NP_001355714.1  neuronal-specific septin-3 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Consensus CDS
    CCDS88812.1
    UniProtKB/TrEMBL
    A0A571BE69
    Related
    ENSMUSP00000158597.2, ENSMUST00000238416.3
    Conserved Domains (1) summary
    cd01850
    Location:527 → 801
    CDC_Septin; CDC/Septin GTPase family

  11. NM_011889.4 → NP_036019.2  neuronal-specific septin-3 isoform 3

    See identical proteins and their annotated locations for NP_036019.2

    Status: VALIDATED

    Source sequence(s)
    AC104325
    Consensus CDS
    CCDS37157.1
    UniProtKB/Swiss-Prot
    Q9Z1S5
    Related
    ENSMUSP00000112124.2, ENSMUST00000116423.3
    Conserved Domains (1) summary
    cd01850
    Location:46 → 320
    CDC_Septin; CDC/Septin GTPase family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    82153003..82178775
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248568.2 → XP_030104428.1  neuronal-specific septin-3 isoform X1

    Conserved Domains (1) summary
    cd01850
    Location:527 → 801
    CDC_Septin; CDC/Septin GTPase family

  2. XM_036159411.1 → XP_036015304.1  neuronal-specific septin-3 isoform X2

    Conserved Domains (1) summary
    cd01850
    Location:143 → 416
    CDC_Septin; CDC/Septin GTPase family

  3. XM_030248570.1 → XP_030104430.1  neuronal-specific septin-3 isoform X2

    Conserved Domains (1) summary
    cd01850
    Location:143 → 416
    CDC_Septin; CDC/Septin GTPase family

  4. XM_030248571.1 → XP_030104431.1  neuronal-specific septin-3 isoform X3

    UniProtKB/TrEMBL
    A0A2R8W6V9
    Conserved Domains (1) summary
    cd01850
    Location:46 → 320
    CDC_Septin; CDC/Septin GTPase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1S5.2 GenPept UniProtKB/Swiss-Prot:Q9Z1S5

Gene LinkOut

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