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Zfp563 zinc finger protein 563 [ Mus musculus (house mouse) ]

Gene ID: 240068, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp563provided by MGI
Official Full Name
zinc finger protein 563provided by MGI
Primary source
MGI:MGI:2677168
See related
Ensembl:ENSMUSG00000067424 AllianceGenome:MGI:2677168
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NTfin7; Zfp413; D130054H01
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system and genitourinary system. Orthologous to human ZNF563 (zinc finger protein 563). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 2.6), whole brain E14.5 (RPKM 2.1) and 23 other tissues See more
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Genomic context

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See Zfp563 in Genome Data Viewer
Location:
17 B1; 17 17.98 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (33308341..33340098)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33089367..33110707)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 763 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33170086-33170195 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33170311-33170494 Neighboring gene STARR-seq mESC enhancer starr_42403 Neighboring gene PHD finger protein 8 like Neighboring gene STARR-positive B cell enhancer ABC_E4206 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:33226471-33226658 Neighboring gene STARR-seq mESC enhancer starr_42404 Neighboring gene microrchidia 2B Neighboring gene predicted gene, 52288 Neighboring gene predicted gene, 21062

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Gene content of the 750-kb critical region for mouse embryonic ectoderm lethal tcl-w5. Abe K, et al. Mamm Genome, 2004 Apr. PMID 15112104
  2. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  3. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 563
Names
Novel zinc finger protein
zinc finger protein NTfin7
zinc finger protein ZFP413

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024950.2 → NP_001020121.2  zinc finger protein 563

    See identical proteins and their annotated locations for NP_001020121.2

    Status: VALIDATED

    Source sequence(s)
    BB662414, BY329545, CAAA01126850
    Consensus CDS
    CCDS50063.1
    UniProtKB/TrEMBL
    B8JJZ9
    Related
    ENSMUSP00000118809.2, ENSMUST00000131722.9
    Conserved Domains (3) summary
    COG5048
    Location:167 → 328
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311 → 331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3 → 44
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    33308341..33340098
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524255.5 → XP_006524318.1  zinc finger protein 563 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:189 → 350
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:333 → 353
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_006524256.3 → XP_006524319.1  zinc finger protein 563 isoform X2

    See identical proteins and their annotated locations for XP_006524319.1

    UniProtKB/TrEMBL
    B8JJZ9
    Conserved Domains (3) summary
    COG5048
    Location:167 → 328
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:311 → 331
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:3 → 44
    KRAB; KRAB box

  3. XM_036160604.1 → XP_036016497.1  zinc finger protein 563 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:135 → 296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:279 → 299
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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