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Ptpn21 protein tyrosine phosphatase, non-receptor type 21 [ Mus musculus (house mouse) ]

Gene ID: 24000, updated on 18-Sep-2024

Summary

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Official Symbol
Ptpn21provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 21provided by MGI
Primary source
MGI:MGI:1344406
See related
Ensembl:ENSMUSG00000021009 AllianceGenome:MGI:1344406
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTPD1; PTPRL10
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human PTPN21 (protein tyrosine phosphatase non-receptor type 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 9.4), ovary adult (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Ptpn21 in Genome Data Viewer
Location:
12 E; 12 49.88 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (98643000..98703664, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (98676741..98737613, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr12:99839121-99839422 Neighboring gene predicted gene, 25486 Neighboring gene STARR-seq mESC enhancer starr_32998 Neighboring gene spermatogenesis associated 7 Neighboring gene STARR-seq mESC enhancer starr_33000 Neighboring gene STARR-positive B cell enhancer ABC_E9861 Neighboring gene zinc finger CCCH type containing 14 Neighboring gene echinoderm microtubule associated protein like 5 Neighboring gene predicted gene, 35463

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics. Ni F, et al. Cell Stem Cell, 2019 Apr 4. PMID 30880025, Free PMC Article
  2. Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration. Carlucci A, et al. J Biol Chem, 2008 Apr 18. PMID 18223254
  3. PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport. Siddiqui N, et al. Nat Commun, 2019 Jun 19. PMID 31217419, Free PMC Article
  4. Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1. Higashitsuji H, et al. Oncogene, 1995 Jan 19. PMID 7838537
  5. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Cardone L, et al. Mol Cell Biol, 2004 Jun. PMID 15143158, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Ptpn21 maintains cellular mechanics, which is correlated with its important functions in Hematopoietic stem cell (HSC) niche retention and preservation of hematopoietic regeneration capacity.
    Title: Ptpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
  2. Study shows that the microtubule binding surface of Kif1c motor domain interacts with its stalk and that these autoinhibitory interactions are released upon binding of protein tyrosine phosphatase Ptpn21. The FERM domain of Ptpn21 stimulates dense core vesicle transport in primary hippocampal neurons and rescues integrin trafficking in Kif1c-depleted cells.
    Title: PTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
  3. PTPD1 is a component of a multivalent scaffold complex nucleated by FAK at specific intracellular sites
    Title: Protein-tyrosine phosphatase PTPD1 regulates focal adhesion kinase autophosphorylation and cell migration.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

General gene information

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Homology

Clone Names

  • MGC107492

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 21
Names
protein-tyrosine phosphatase PTP-RL10
NP_001139671.1
NP_036007.2
XP_011242414.1
XP_036013301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146199.1 → NP_001139671.1  tyrosine-protein phosphatase non-receptor type 21

    See identical proteins and their annotated locations for NP_001139671.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124516, AC159193, BC098500
    Consensus CDS
    CCDS26098.1
    UniProtKB/TrEMBL
    G5E8J4, Q4KML9
    Related
    ENSMUSP00000126975.2, ENSMUST00000170188.8
    Conserved Domains (6) summary
    smart00194
    Location:898 → 1168
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:925 → 1168
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:217 → 307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:109 → 220
    FERM_M; FERM central domain
    pfam09379
    Location:27 → 90
    FERM_N; FERM N-terminal domain

  2. NM_011877.2 → NP_036007.2  tyrosine-protein phosphatase non-receptor type 21

    See identical proteins and their annotated locations for NP_036007.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124516, AC159193, BC098500
    Consensus CDS
    CCDS26098.1
    UniProtKB/TrEMBL
    G5E8J4, Q4KML9
    Related
    ENSMUSP00000082197.3, ENSMUST00000085116.4
    Conserved Domains (6) summary
    smart00194
    Location:898 → 1168
    PTPc; Protein tyrosine phosphatase, catalytic domain
    smart00295
    Location:24 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:925 → 1168
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd13188
    Location:217 → 307
    FERM_C_PTPN14_PTPN21; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 14 and 21 (PTPN14 and 21)
    pfam00373
    Location:109 → 220
    FERM_M; FERM central domain
    pfam09379
    Location:27 → 90
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    98643000..98703664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244112.4 → XP_011242414.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

    UniProtKB/TrEMBL
    Q7TMG1
    Conserved Domains (1) summary
    cl28904
    Location:471 → 757
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_036157408.1 → XP_036013301.1  tyrosine-protein phosphatase non-receptor type 21 isoform X1

    UniProtKB/TrEMBL
    Q7TMG1
    Conserved Domains (1) summary
    cl28904
    Location:471 → 757
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62136.1 GenPept UniProtKB/Swiss-Prot:Q62136

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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