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Eci2 enoyl-Coenzyme A delta isomerase 2 [ Mus musculus (house mouse) ]

Gene ID: 23986, updated on 6-Oct-2024

Summary

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Official Symbol
Eci2provided by MGI
Official Full Name
enoyl-Coenzyme A delta isomerase 2provided by MGI
Primary source
MGI:MGI:1346064
See related
Ensembl:ENSMUSG00000021417 AllianceGenome:MGI:1346064
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Drs1; Peci; Acbd2; Hca88
Summary
Enables dodecenoyl-CoA delta-isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion and peroxisome. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human ECI2 (enoyl-CoA delta isomerase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 30.7), liver adult (RPKM 24.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Eci2 in Genome Data Viewer
Location:
13 A3.3; 13 14.23 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (35161731..35211098, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (34977748..35027115, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene testis expressed 56 Neighboring gene STARR-seq mESC enhancer starr_34165 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene enoyl-Coenzyme A delta isomerase 3 Neighboring gene predicted gene, 16984 Neighboring gene STARR-seq mESC enhancer starr_34167 Neighboring gene STARR-seq mESC enhancer starr_34168 Neighboring gene predicted gene, 46408 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:35127596-35127929 Neighboring gene STARR-seq mESC enhancer starr_34169 Neighboring gene predicted gene, 40910 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:35221416-35221651 Neighboring gene STARR-positive B cell enhancer mm9_chr13:35223226-35223527 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:35223796-35223979 Neighboring gene STARR-seq mESC enhancer starr_34170 Neighboring gene RIKEN cDNA 4930529N20 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of PECI, a novel monofunctional Delta(3), Delta(2)-enoyl-CoA isomerase of mammalian peroxisomes. Geisbrecht BV, et al. J Biol Chem, 1999 Jul 30. PMID 10419495
  2. Identification and characterization of Eci3, a murine kidney-specific Δ3,Δ2-enoyl-CoA isomerase. van Weeghel M, et al. FASEB J, 2014 Mar. PMID 24344334
  3. Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease. Kikuchi M, et al. J Biol Chem, 2004 Jan 2. PMID 14561759
  4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Kim SC, et al. Mol Cell, 2006 Aug. PMID 16916647
  5. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delta(3)-delta(2)-enoyl-CoA isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISO
Inferred from Sequence Orthology
more info
  
enables delta(3)-delta(2)-enoyl-CoA isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables fatty-acyl-CoA binding IEA
Inferred from Electronic Annotation
more info
  
enables intramolecular oxidoreductase activity, transposing C=C bonds ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid beta-oxidation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal matrix IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal matrix ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisomal matrix ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
enoyl-CoA delta isomerase 2
Names
D3,D2-enoyl-CoA isomerase
delta(3),delta(2)-enoyl-CoA isomerase
dodecenoyl-CoA isomerase
enoyl-CoA delta isomerase 2, mitochondrial
peroxisomal 3,2-trans-enoyl-CoA isomerase
peroxisomal delta3, delta2-enoyl-Coenzyme A isomerase
NP_001103801.1
NP_035998.2
XP_006516736.1
XP_006516737.1
XP_006516738.1
XP_006516739.1
XP_006516740.1
XP_030103124.1
XP_030103125.1
XP_030103126.1
XP_036013943.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110331.1 → NP_001103801.1  enoyl-CoA delta isomerase 2 isoform a

    See identical proteins and their annotated locations for NP_001103801.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK009478, BQ176032, BY037058
    Consensus CDS
    CCDS49234.1
    UniProtKB/Swiss-Prot
    Q99M61, Q9D785, Q9WUR2
    UniProtKB/TrEMBL
    Q3TCD4
    Related
    ENSMUSP00000131735.2, ENSMUST00000171229.8
    Conserved Domains (2) summary
    pfam00887
    Location:38 → 113
    ACBP; Acyl CoA binding protein
    cl23717
    Location:139 → 389
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  2. NM_011868.3 → NP_035998.2  enoyl-CoA delta isomerase 2 isoform b

    See identical proteins and their annotated locations for NP_035998.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream initiation codon, compared to variant 1. The resulting protein (isoform b) is shorter at the N-terminus, compared to isoform a. Both variants 2 and 3 encode the same isoform.
    Source sequence(s)
    AK009478, BQ176032, BY037058, CX242291
    Consensus CDS
    CCDS26450.1
    UniProtKB/TrEMBL
    Q3TCD4
    Related
    ENSMUSP00000021854.7, ENSMUST00000021854.14
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:106 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RNA

  1. NR_073427.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' exon structure compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK009478, BQ176032, BY037058, BY238570
    Related
    ENSMUST00000110251.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    35161731..35211098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516677.2 → XP_006516740.1  enoyl-CoA delta isomerase 2 isoform X1

    See identical proteins and their annotated locations for XP_006516740.1

    UniProtKB/TrEMBL
    Q3TCD4
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:106 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  2. XM_006516676.4 → XP_006516739.1  enoyl-CoA delta isomerase 2 isoform X1

    See identical proteins and their annotated locations for XP_006516739.1

    UniProtKB/TrEMBL
    Q3TCD4
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:106 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  3. XM_030247264.1 → XP_030103124.1  enoyl-CoA delta isomerase 2 isoform X1

    UniProtKB/TrEMBL
    Q3TCD4
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:106 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  4. XM_006516674.4 → XP_006516737.1  enoyl-CoA delta isomerase 2 isoform X1

    See identical proteins and their annotated locations for XP_006516737.1

    UniProtKB/TrEMBL
    Q3TCD4
    Related
    ENSMUSP00000137411.2, ENSMUST00000178421.8
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:106 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  5. XM_006516675.3 → XP_006516738.1  enoyl-CoA delta isomerase 2 isoform X1

    See identical proteins and their annotated locations for XP_006516738.1

    UniProtKB/TrEMBL
    Q3TCD4
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:106 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  6. XM_030247265.2 → XP_030103125.1  enoyl-CoA delta isomerase 2 isoform X2

    Conserved Domains (1) summary
    cl23717
    Location:1 → 224
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  7. XM_006516673.4 → XP_006516736.1  enoyl-CoA delta isomerase 2 isoform X1

    See identical proteins and their annotated locations for XP_006516736.1

    UniProtKB/TrEMBL
    Q3TCD4
    Conserved Domains (2) summary
    pfam00887
    Location:5 → 80
    ACBP; Acyl CoA binding protein
    cl23717
    Location:106 → 356
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  8. XM_036158050.1 → XP_036013943.1  enoyl-CoA delta isomerase 2 isoform X2

    Conserved Domains (1) summary
    cl23717
    Location:1 → 224
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  9. XM_030247266.2 → XP_030103126.1  enoyl-CoA delta isomerase 2 isoform X2

    Conserved Domains (1) summary
    cl23717
    Location:1 → 224
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001110332.1: Suppressed sequence

    Description
    NM_001110332.1: This RefSeq was permanently suppressed because it is now thought that this transcript does not encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUR2.2 GenPept UniProtKB/Swiss-Prot:Q9WUR2

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