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Macc1 metastasis associated in colon cancer 1 [ Mus musculus (house mouse) ]

Gene ID: 238455, updated on 5-Mar-2024

Summary

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Official Symbol
Macc1provided by MGI
Official Full Name
metastasis associated in colon cancer 1provided by MGI
Primary source
MGI:MGI:2685113
See related
Ensembl:ENSMUSG00000041886 AllianceGenome:MGI:2685113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm267; 4732474O15Rik
Summary
Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in epithelium of phallic urethra of male and urethral plate. Orthologous to human MACC1 (MET transcriptional regulator MACC1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 1.7), limb E14.5 (RPKM 0.3) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Macc1 in Genome Data Viewer
Location:
12 F2; 12 63.48 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (119354133..119430669)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (119390398..119466934)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46331 Neighboring gene PRA1 domain family 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_33457 Neighboring gene NOP2 nucleolar protein homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_33458 Neighboring gene STARR-seq mESC enhancer starr_33459 Neighboring gene STARR-seq mESC enhancer starr_33460 Neighboring gene STARR-seq mESC enhancer starr_33461 Neighboring gene 60S ribosomal protein L5 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Metastasis-associated in colon cancer-1 upregulates vascular endothelial growth factor-C/D to promote lymphangiogenesis in human gastric cancer. Sun L, et al. Cancer Lett, 2015 Feb 1. PMID 25444928
  2. In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice. Pichorner A, et al. Clin Exp Metastasis, 2012 Aug. PMID 22484916
  3. Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice. Chen XP, et al. Mol Biol Rep, 2014 Mar. PMID 24469707
  4. MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis. Stein U, et al. Nat Med, 2009 Jan. PMID 19098908
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.
    Title: Metastasis-associated in colon cancer-1 upregulates vascular endothelial growth factor-C/D to promote lymphangiogenesis in human gastric cancer.
  2. HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer
    Title: Analysis of HGF, MACC1, C-met and apoptosis-related genes in cervical carcinoma mice.
  3. MACC1 has a role in colorectal cancer and can be used for imaging in xenografts
    Title: In vivo imaging of colorectal cancer growth and metastasis by targeting MACC1 with shRNA in xenografted mice.
  4. MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.
    Title: MACC1, a newly identified key regulator of HGF-MET signaling, predicts colon cancer metastasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metastasis-associated in colon cancer protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163136.1 → NP_001156608.1  metastasis-associated in colon cancer protein 1

    See identical proteins and their annotated locations for NP_001156608.1

    Status: VALIDATED

    Source sequence(s)
    AC132596, AC138307
    Consensus CDS
    CCDS49199.1
    UniProtKB/TrEMBL
    E9PXX8
    Related
    ENSMUSP00000042955.7, ENSMUST00000048880.7
    Conserved Domains (2) summary
    pfam07653
    Location:552 → 616
    SH3_2; Variant SH3 domain
    cl02517
    Location:219 → 290
    ZU5; ZU5 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    119354133..119430669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515863.3 → XP_006515926.1  metastasis-associated in colon cancer protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006515926.1

    UniProtKB/TrEMBL
    E9PXX8
    Conserved Domains (2) summary
    pfam07653
    Location:552 → 616
    SH3_2; Variant SH3 domain
    cl02517
    Location:219 → 290
    ZU5; ZU5 domain

  2. XM_006515861.4 → XP_006515924.1  metastasis-associated in colon cancer protein 1 isoform X1

    Conserved Domains (2) summary
    pfam07653
    Location:562 → 626
    SH3_2; Variant SH3 domain
    cl02517
    Location:229 → 300
    ZU5; ZU5 domain

  3. XM_006515862.2 → XP_006515925.1  metastasis-associated in colon cancer protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006515925.1

    UniProtKB/TrEMBL
    E9PXX8
    Related
    ENSMUSP00000152123.2, ENSMUST00000222058.2
    Conserved Domains (2) summary
    pfam07653
    Location:552 → 616
    SH3_2; Variant SH3 domain
    cl02517
    Location:219 → 290
    ZU5; ZU5 domain
Nucleotide Protein Strain
Heading Accession and Version

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