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Zdhhc22 zinc finger, DHHC-type containing 22 [ Mus musculus (house mouse) ]

Gene ID: 238331, updated on 30-Apr-2024

Summary

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Official Symbol
Zdhhc22provided by MGI
Official Full Name
zinc finger, DHHC-type containing 22provided by MGI
Primary source
MGI:MGI:2685108
See related
Ensembl:ENSMUSG00000048483 AllianceGenome:MGI:2685108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm262
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Acts upstream of or within protein localization to plasma membrane and protein palmitoylation. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC22 (zinc finger DHHC-type palmitoyltransferase 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 9.7), frontal lobe adult (RPKM 6.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Zdhhc22 in Genome Data Viewer
Location:
12 D2; 12 41.17 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (87027537..87037604, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86980763..86990830, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32856 Neighboring gene predicted gene, 53735 Neighboring gene STARR-seq mESC enhancer starr_32861 Neighboring gene STARR-seq mESC enhancer starr_32863 Neighboring gene STARR-seq mESC enhancer starr_32864 Neighboring gene STARR-positive B cell enhancer ABC_E10769 Neighboring gene predicted gene, 32934 Neighboring gene CLOCK interacting protein, circadian Neighboring gene transmembrane protein 63c Neighboring gene crumbs homolog 1 pseudogene Neighboring gene neuroglobin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CCN3 secretion is regulated by palmitoylation via ZDHHC22. Kim Y, et al. Biochem Biophys Res Commun, 2018 Jan 22. PMID 29287726
  2. Distinct acyl protein transferases and thioesterases control surface expression of calcium-activated potassium channels. Tian L, et al. J Biol Chem, 2012 Apr 27. PMID 22399288, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Clone Names

  • MGC157624

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC22
Names
DHHC-22
putative palmitoyltransferase ZDHHC22
zinc finger DHHC domain-containing protein 22
NP_001074412.1
NP_001363954.1
XP_006515916.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080943.3 → NP_001074412.1  palmitoyltransferase ZDHHC22

    See identical proteins and their annotated locations for NP_001074412.1

    Status: VALIDATED

    Source sequence(s)
    AC153147
    Consensus CDS
    CCDS36500.1
    UniProtKB/Swiss-Prot
    A0PK84
    Related
    ENSMUSP00000152660.2, ENSMUST00000222543.2
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 218
    DHHC; DHHC palmitoyltransferase

  2. NM_001377025.1 → NP_001363954.1  palmitoyltransferase ZDHHC22

    Status: VALIDATED

    Source sequence(s)
    AC153147
    UniProtKB/Swiss-Prot
    A0PK84
    Related
    ENSMUSP00000093177.3, ENSMUST00000095521.3
    Conserved Domains (1) summary
    pfam01529
    Location:91 → 218
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    87027537..87037604 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515853.5 → XP_006515916.1  palmitoyltransferase ZDHHC22 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:91 → 180
    DHHC; DHHC palmitoyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0PK84.1 GenPept UniProtKB/Swiss-Prot:A0PK84

Gene LinkOut

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