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Rps6kl1 ribosomal protein S6 kinase-like 1 [ Mus musculus (house mouse) ]

Gene ID: 238323, updated on 28-Oct-2024

Summary

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Official Symbol
Rps6kl1provided by MGI
Official Full Name
ribosomal protein S6 kinase-like 1provided by MGI
Primary source
MGI:MGI:2443413
See related
Ensembl:ENSMUSG00000019235 AllianceGenome:MGI:2443413
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A830084F09Rik
Summary
Predicted to enable ATP binding activity; histone H2AS1 kinase activity; and protein serine kinase activity. Predicted to be involved in chromatin remodeling and protein phosphorylation. Predicted to be located in ribosome. Predicted to be part of ribonucleoprotein complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; hindlimb mesenchyme; and nervous system. Orthologous to human RPS6KL1 (ribosomal protein S6 kinase like 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E18 (RPKM 11.8), cortex adult (RPKM 9.0) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Rps6kl1 in Genome Data Viewer
Location:
12 D1; 12 39.57 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (85182023..85198052, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (85135249..85151277, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene prospero homeobox 2 opposite strand Neighboring gene prospero homeobox 2 Neighboring gene dihydrolipoamide S-succinyltransferase Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:86464102-86464289 Neighboring gene STARR-seq mESC enhancer starr_32766 Neighboring gene placental growth factor Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC38756

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase-like 1
NP_001351244.1
NP_001351245.1
NP_001351246.1
NP_666356.2
XP_006515911.1
XP_006515912.1
XP_030102567.1
XP_030102568.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364315.1 → NP_001351244.1  ribosomal protein S6 kinase-like 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC127582, AK031847
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 535
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  2. NM_001364316.1 → NP_001351245.1  ribosomal protein S6 kinase-like 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127582
    Conserved Domains (2) summary
    cd02677
    Location:48 → 112
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:138 → 525
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  3. NM_001364317.1 → NP_001351246.1  ribosomal protein S6 kinase-like 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC127582
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 518
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  4. NM_146244.4 → NP_666356.2  ribosomal protein S6 kinase-like 1 isoform 2

    See identical proteins and their annotated locations for NP_666356.2

    Status: VALIDATED

    Source sequence(s)
    AK044050, BY124367, BY651033
    Consensus CDS
    CCDS36496.1
    UniProtKB/Swiss-Prot
    Q8R1D4, Q8R2S1
    Related
    ENSMUSP00000152336.2, ENSMUST00000221972.2
    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 534
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    85182023..85198052 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246708.2 → XP_030102568.1  ribosomal protein S6 kinase-like 1 isoform X4

    UniProtKB/TrEMBL
    A0A217FL57
    Conserved Domains (2) summary
    cd02677
    Location:48 → 112
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:138 → 508
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  2. XM_006515849.5 → XP_006515912.1  ribosomal protein S6 kinase-like 1 isoform X3

    UniProtKB/TrEMBL
    A0A217FL57
    Related
    ENSMUSP00000019379.9, ENSMUST00000019379.9
    Conserved Domains (2) summary
    cd02677
    Location:48 → 112
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:138 → 509
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  3. XM_030246707.2 → XP_030102567.1  ribosomal protein S6 kinase-like 1 isoform X1

    Conserved Domains (2) summary
    cd02677
    Location:48 → 112
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:138 → 524
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins

  4. XM_006515848.5 → XP_006515911.1  ribosomal protein S6 kinase-like 1 isoform X2

    Conserved Domains (2) summary
    cd02677
    Location:48 → 122
    MIT_SNX15; MIT: domain contained within Microtubule Interacting and Trafficking molecules. This MIT domain sub-family is found in sorting nexin 15 and related proteins. The molecular function of the MIT domain is unclear.
    cd05576
    Location:148 → 519
    STKc_RPK118_like; Catalytic domain of the Serine/Threonine Kinase, RPK118, and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R2S1.1 GenPept UniProtKB/Swiss-Prot:Q8R2S1

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