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Arih1 ariadne RBR E3 ubiquitin protein ligase 1 [ Mus musculus (house mouse) ]

Gene ID: 23806, updated on 2-Nov-2024

Summary

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Official Symbol
Arih1provided by MGI
Official Full Name
ariadne RBR E3 ubiquitin protein ligase 1provided by MGI
Primary source
MGI:MGI:1344363
See related
Ensembl:ENSMUSG00000025234 AllianceGenome:MGI:1344363
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ari; Ari1; Hari; Hhari; Uip77; Ubch7bp
Summary
Predicted to enable enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in Lewy body and nuclear body. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in hippocampus. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 9.4), testis adult (RPKM 8.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Arih1 in Genome Data Viewer
Location:
9 B; 9 32.01 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (59295837..59395469, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (59388554..59488186, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:59138959-59139219 Neighboring gene ADP-dependent glucokinase Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:59201235-59201388 Neighboring gene STARR-seq mESC enhancer starr_24298 Neighboring gene STARR-seq mESC enhancer starr_24299 Neighboring gene STARR-seq mESC enhancer starr_24300 Neighboring gene STARR-seq mESC enhancer starr_24301 Neighboring gene STARR-seq mESC enhancer starr_24302 Neighboring gene ribosomal protein S11, pseudogene 1 Neighboring gene STARR-positive B cell enhancer mm9_chr9:59334521-59334822 Neighboring gene predicted gene, 20199 Neighboring gene predicted gene, 33180 Neighboring gene transmembrane protein 202 Neighboring gene hexosaminidase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain. González-Barbosa E, et al. J Biochem Mol Toxicol, 2017 Oct. PMID 28621812, Free PMC Article
  2. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS. Xiong TC, et al. Nat Commun, 2022 Oct 10. PMID 36217001, Free PMC Article
  3. The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest. von Stechow L, et al. Mol Cell Biol, 2015 Apr. PMID 25624349, Free PMC Article
  4. Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. Kathania M, et al. J Immunol, 2015 Mar 1. PMID 25632008
  5. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. Moynihan TP, et al. J Biol Chem, 1999 Oct 22. PMID 10521492

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.
    Title: The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.
  2. 2,3,7,8-tetrachlorodibenzo-p-dioxin promotes the aryl hydrocarbon receptor binding to Ubch7 gene promoter as well as its transactivation, resulting in an induction of UbcH7 levels in the olfactory bulb, ventral midbrain, hippocampus, striatum, cerebral cortex, brain stem, and medulla oblongata.
    Title: TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain.
  3. DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with 4EHP. In turn, this causes 4EHP recruitment to the mRNA cap, where it is known to compete with eIF4E.
    Title: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
  4. Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
    Title: Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6)  1 citation
  • Gene trapped (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin conjugating enzyme binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Cajal body IEA
Inferred from Electronic Annotation
more info
  
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul2-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Cul3-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul3-RING ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of Cul4A-RING E3 ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Lewy body ISO
Inferred from Sequence Orthology
more info
  
located_in Lewy body ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of SCF ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  
part_of SCF ubiquitin ligase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ARIH1
Names
ARI-1
RING-type E3 ubiquitin transferase ARIH1
UbcH7-binding protein
UbcM4-interacting protein 77
ariadne 1
ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1
protein ariadne-1 homolog
ubiquitin-conjugating enzyme E2-binding protein 1
NP_064311.2
XP_006511203.1
XP_006511204.1
XP_011241041.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019927.2 → NP_064311.2  E3 ubiquitin-protein ligase ARIH1

    See identical proteins and their annotated locations for NP_064311.2

    Status: VALIDATED

    Source sequence(s)
    AJ130977, AK032640, AK047617, AW125831, CA328699, CJ176800, CK633971, CV555932
    Consensus CDS
    CCDS52817.1
    UniProtKB/Swiss-Prot
    E9Q1X3, Q6PF92, Q8CFJ4, Q9Z1K5
    UniProtKB/TrEMBL
    H9KV21
    Related
    ENSMUSP00000126531.2, ENSMUST00000171975.8
    Conserved Domains (3) summary
    smart00647
    Location:255 → 315
    IBR; In Between Ring fingers
    cd16626
    Location:183 → 240
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:337 → 377
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    59295837..59395469 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511140.4 → XP_006511203.1  E3 ubiquitin-protein ligase ARIH1 isoform X1

    UniProtKB/TrEMBL
    H9KV21
    Conserved Domains (3) summary
    smart00647
    Location:196 → 256
    IBR; In Between Ring fingers
    cd16626
    Location:124 → 181
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:278 → 318
    IBR; IBR domain, a half RING-finger domain

  2. XM_006511141.3 → XP_006511204.1  E3 ubiquitin-protein ligase ARIH1 isoform X3

    UniProtKB/TrEMBL
    H9KV21
    Conserved Domains (3) summary
    smart00647
    Location:165 → 225
    IBR; In Between Ring fingers
    cd16626
    Location:93 → 150
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:247 → 287
    IBR; IBR domain, a half RING-finger domain

  3. XM_011242739.3 → XP_011241041.1  E3 ubiquitin-protein ligase ARIH1 isoform X2

    UniProtKB/TrEMBL
    H9KV21
    Conserved Domains (3) summary
    smart00647
    Location:173 → 233
    IBR; In Between Ring fingers
    cd16626
    Location:101 → 158
    RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins
    pfam01485
    Location:255 → 295
    IBR; IBR domain, a half RING-finger domain

RNA

  1. XR_004935434.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1K5.3 GenPept UniProtKB/Swiss-Prot:Q9Z1K5

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