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Aoc2 amine oxidase copper containing 2 [ Mus musculus (house mouse) ]

Gene ID: 237940, updated on 2-Nov-2024

Summary

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Official Symbol
Aoc2provided by MGI
Official Full Name
amine oxidase copper containing 2provided by MGI
Primary source
MGI:MGI:2668431
See related
Ensembl:ENSMUSG00000078651 AllianceGenome:MGI:2668431
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RAO
Summary
Predicted to enable copper ion binding activity and primary methylamine oxidase activity. Predicted to be involved in amine metabolic process. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human AOC2 (amine oxidase copper containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 7.8), mammary gland adult (RPKM 6.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Aoc2 in Genome Data Viewer
Location:
11 D; 11 64.7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101214467..101220633)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101323640..101329807)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1, autophagy related Neighboring gene STARR-positive B cell enhancer ABC_E2370 Neighboring gene STARR-positive B cell enhancer ABC_E7066 Neighboring gene proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) Neighboring gene amine oxidase, copper containing 3 Neighboring gene glucose-6-phosphatase catalytic subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of AOC2 gene encoding a copper-binding amine oxidase expressed specifically in retina. Zhang Q, et al. Gene, 2003 Oct 30. PMID 14585497
  2. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aliphatic amine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables copper ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables copper ion binding IEA
Inferred from Electronic Annotation
more info
  
enables primary methylamine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables primary methylamine oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables primary methylamine oxidase activity ISO
Inferred from Sequence Orthology
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
amine oxidase [copper-containing] 2; retina-specific copper amine oxidase
Names
amine oxidase, copper containing 2 (retina-specific)
retina-specific amine oxidase
NP_849263.1
XP_017170022.1
XP_017170024.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178932.1 → NP_849263.1  amine oxidase [copper-containing] 2

    See identical proteins and their annotated locations for NP_849263.1

    Status: PROVISIONAL

    Source sequence(s)
    AF350445
    Consensus CDS
    CCDS25464.1
    UniProtKB/Swiss-Prot
    A2A4J0, Q80WP3, Q812C9
    UniProtKB/TrEMBL
    A2A4I9
    Related
    ENSMUSP00000040255.8, ENSMUST00000041095.14
    Conserved Domains (4) summary
    PRK11504
    Location:59 → 719
    tynA; tyramine oxidase; Provisional
    pfam01179
    Location:314 → 717
    Cu_amine_oxid; Copper amine oxidase, enzyme domain
    pfam02727
    Location:62 → 148
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:165 → 263
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101214467..101220633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314533.3 → XP_017170022.1  retina-specific copper amine oxidase isoform X1

    UniProtKB/TrEMBL
    A2A4I9
    Conserved Domains (3) summary
    pfam02727
    Location:62 → 148
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:165 → 262
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain
    pfam01179
    Location:308 → 654
    Cu_amine_oxid; Copper amine oxidase, enzyme domain

  2. XM_017314535.3 → XP_017170024.1  retina-specific copper amine oxidase isoform X2

    Conserved Domains (3) summary
    pfam02727
    Location:62 → 148
    Cu_amine_oxidN2; Copper amine oxidase, N2 domain
    pfam02728
    Location:165 → 262
    Cu_amine_oxidN3; Copper amine oxidase, N3 domain
    pfam01179
    Location:308 → 552
    Cu_amine_oxid; Copper amine oxidase, enzyme domain

RNA

  1. XR_004936952.1 RNA Sequence

  2. XR_004936953.1 RNA Sequence

  3. XR_004936954.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q812C9.2 GenPept UniProtKB/Swiss-Prot:Q812C9

Gene LinkOut

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