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Osbpl8 oxysterol binding protein-like 8 [ Mus musculus (house mouse) ]

Gene ID: 237542, updated on 2-Nov-2024

Summary

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Official Symbol
Osbpl8provided by MGI
Official Full Name
oxysterol binding protein-like 8provided by MGI
Primary source
MGI:MGI:2443807
See related
Ensembl:ENSMUSG00000020189 AllianceGenome:MGI:2443807
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ORP-8; C730029P18Rik; D330025H14Rik
Summary
This gene encodes a member of the oxysterol-binding protein (Osbp) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal Osbp-like sterol-binding domain. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E18 (RPKM 7.5), frontal lobe adult (RPKM 6.6) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Osbpl8 in Genome Data Viewer
Location:
10 D1; 10 58.24 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (111000663..111133110)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (111164742..111297249)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_27861 Neighboring gene ribosomal protein L6-like Neighboring gene STARR-positive B cell enhancer ABC_E8365 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:110594402-110594585 Neighboring gene STARR-seq mESC enhancer starr_27862 Neighboring gene STARR-positive B cell enhancer ABC_E2339 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:110602548-110602735 Neighboring gene coiled-coil domain containing 99 pseudogene Neighboring gene predicted gene, 17849 Neighboring gene microRNA 12180 Neighboring gene STARR-positive B cell enhancer ABC_E5180 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:110735920-110736029 Neighboring gene predicted gene, 40760 Neighboring gene Bardet-Biedl syndrome 10 Neighboring gene predicted gene, 30095

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ChIP Display: novel method for identification of genomic targets of transcription factors. Barski A, et al. Nucleic Acids Res, 2004 Jul 13. PMID 15252151, Free PMC Article
  2. Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism. Béaslas O, et al. PLoS One, 2013. PMID 23554939, Free PMC Article
  3. Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice. van Kampen E, et al. PLoS One, 2014. PMID 25347070, Free PMC Article
  4. Activin A impairs insulin action in cardiomyocytes via up-regulation of miR-143. Blumensatt M, et al. Cardiovasc Res, 2013 Nov 1. PMID 23812417
  5. Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity. Béaslas O, et al. Exp Cell Res, 2012 Sep 10. PMID 22683860

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice.
    Title: Orp8 deficiency in bone marrow-derived cells reduces atherosclerotic lesion progression in LDL receptor knockout mice.
  2. Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.
    Title: Osbpl8 deficiency in mouse causes an elevation of high-density lipoproteins and gender-specific alterations of lipid metabolism.
  3. aspects of ORP8 function in macrophages not directly involving lipid metabolism, but rather associated with nuclear functions, microtubule organization, and migration capacity
    Title: Silencing of OSBP-related protein 8 (ORP8) modifies the macrophage transcriptome, nucleoporin p62 distribution, and migration capacity.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cholesterol binding IEA
Inferred from Electronic Annotation
more info
  
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylserine binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine transfer activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fat cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in intermembrane lipid transfer IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of sequestering of triglyceride IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of sequestering of triglyceride ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipid transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of D-glucose import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to nuclear pore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
oxysterol-binding protein-related protein 8
Names
OSBP-related protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003717.1 → NP_001003717.1  oxysterol-binding protein-related protein 8 isoform b

    See identical proteins and their annotated locations for NP_001003717.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, resulting in the use of a downstream in-frame start codon compared to variant 1. Variant 2 encodes isoform b, which has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AA536976, AK037869, AK050244, AK052311, BU152326, CF745582
    Consensus CDS
    CCDS24166.1
    UniProtKB/TrEMBL
    A0A0R4J150
    Related
    ENSMUSP00000092948.2, ENSMUST00000095310.3
    Conserved Domains (2) summary
    cd13286
    Location:100 → 229
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:365 → 702
    Oxysterol_BP; Oxysterol-binding protein

  2. NM_175489.3 → NP_780698.2  oxysterol-binding protein-related protein 8 isoform a

    See identical proteins and their annotated locations for NP_780698.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA536976, AK037158, AK037869, AK050244, AK052311, BU152326, CF745582
    Consensus CDS
    CCDS36056.1
    UniProtKB/Swiss-Prot
    B9EJ86, G3X9N6, Q69ZJ4
    Related
    ENSMUSP00000100911.2, ENSMUST00000105275.9
    Conserved Domains (3) summary
    cd13286
    Location:142 → 271
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam00169
    Location:149 → 265
    PH; PH domain
    pfam01237
    Location:407 → 745
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    111000663..111133110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155782.1 → XP_036011675.1  oxysterol-binding protein-related protein 8 isoform X3

    UniProtKB/TrEMBL
    A0A0R4J150
    Conserved Domains (2) summary
    cd13286
    Location:100 → 229
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:365 → 702
    Oxysterol_BP; Oxysterol-binding protein

  2. XM_006513637.4 → XP_006513700.1  oxysterol-binding protein-related protein 8 isoform X1

    Conserved Domains (2) summary
    cd13286
    Location:139 → 268
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:404 → 741
    Oxysterol_BP; Oxysterol-binding protein

  3. XM_006513638.2 → XP_006513701.1  oxysterol-binding protein-related protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006513701.1

    UniProtKB/TrEMBL
    A0A5F8MPC5
    Related
    ENSMUSP00000158904.2, ENSMUST00000238838.2
    Conserved Domains (2) summary
    cd13286
    Location:118 → 247
    PH_OPR5_ORP8; Human Oxysterol binding protein related proteins 5 and 8 Pleckstrin homology (PH) domain
    pfam01237
    Location:383 → 720
    Oxysterol_BP; Oxysterol-binding protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B9EJ86.1 GenPept UniProtKB/Swiss-Prot:B9EJ86

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