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L3mbtl3 L3MBTL3 histone methyl-lysine binding protein [ Mus musculus (house mouse) ]

Gene ID: 237339, updated on 2-Nov-2024

Summary

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Official Symbol
L3mbtl3provided by MGI
Official Full Name
L3MBTL3 histone methyl-lysine binding proteinprovided by MGI
Primary source
MGI:MGI:2143628
See related
Ensembl:ENSMUSG00000039089 AllianceGenome:MGI:2143628
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MBT-1
Summary
Predicted to enable several functions, including histone binding activity; identical protein binding activity; and methylation-dependent protein binding activity. Involved in regulation of ubiquitin-dependent protein catabolic process. Acts upstream of or within erythrocyte maturation; granulocyte differentiation; and macrophage differentiation. Located in nucleus. Is expressed in retina. Orthologous to human L3MBTL3 (L3MBTL histone methyl-lysine binding protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 9.7), CNS E18 (RPKM 6.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See L3mbtl3 in Genome Data Viewer
Location:
10 A4; 10 13.67 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (26150361..26252426, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (26274461..26376036, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene high mobility group box 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_26120 Neighboring gene STARR-seq mESC enhancer starr_26121 Neighboring gene sterile alpha motif domain containing 3 Neighboring gene STARR-seq mESC enhancer starr_26122 Neighboring gene aldo-keto reductase family 1, member B8 pseudogene Neighboring gene predicted gene, 30034 Neighboring gene STARR-seq mESC enhancer starr_26124 Neighboring gene STARR-seq mESC enhancer starr_26125

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina. Miesfeld JB, et al. Sci Rep, 2018 Jul 5. PMID 29977079, Free PMC Article
  2. Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. Arai S, et al. EMBO J, 2005 May 18. PMID 15889154, Free PMC Article
  3. The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis. Guo P, et al. Nat Commun, 2022 Nov 5. PMID 36335117, Free PMC Article
  4. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1. Xu T, et al. EMBO J, 2017 Nov 2. PMID 29030483, Free PMC Article
  5. Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase. Leng F, et al. Nat Commun, 2018 Apr 24. PMID 29691401, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The direct binding of L3MBTL3 to the methylated SOX2 protein leads to the recruitment of the CRL4(DCAF5) ubiquitin E3 ligase to target SOX2 protein for ubiquitin-dependent proteolysis.
    Title: Proteolysis of methylated SOX2 protein is regulated by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
  2. L3MBTL3 binds the K142-methylated DNMT1 and recruits a novel CRL4(DCAF5) ubiquitin ligase to degrade DNMT1.
    Title: Methylated DNMT1 and E2F1 are targeted for proteolysis by L3MBTL3 and CRL4(DCAF5) ubiquitin ligase.
  3. The mouse MBT-1 protein influences myelopoiesis by transiently enhancing p57(KIP2) expression levels.
    Title: Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90546

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables methylation-dependent protein binding IEA
Inferred from Electronic Annotation
more info
  
enables methylation-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within erythrocyte maturation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within granulocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within myeloid cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within myeloid cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA methylation-dependent heterochromatin formation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
lethal(3)malignant brain tumor-like protein 3
Names
l(3)mbt-like 3
l(3)mbt-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347467.3 → NP_001334396.1  lethal(3)malignant brain tumor-like protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091763, AC152953
    Consensus CDS
    CCDS83689.1
    UniProtKB/Swiss-Prot
    Q8BLB7
    Related
    ENSMUSP00000101158.4, ENSMUST00000105519.10
    Conserved Domains (2) summary
    cd09582
    Location:783 → 848
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:426 → 518
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  2. NM_001359254.2 → NP_001346183.1  lethal(3)malignant brain tumor-like protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091763, AC152953
    Consensus CDS
    CCDS23756.1
    UniProtKB/Swiss-Prot
    Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4
    Related
    ENSMUSP00000037619.7, ENSMUST00000040219.13
    Conserved Domains (3) summary
    cd09582
    Location:808 → 873
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:451 → 543
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:558 → 586
    zf-C2HC; Zinc finger, C2HC type

  3. NM_001359255.2 → NP_001346184.1  lethal(3)malignant brain tumor-like protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC091763, AC152953
    Conserved Domains (2) summary
    cd09582
    Location:732 → 797
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:375 → 467
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  4. NM_001408257.1 → NP_001395186.1  lethal(3)malignant brain tumor-like protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC091763, AC152953
    UniProtKB/Swiss-Prot
    Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4

  5. NM_001408258.1 → NP_001395187.1  lethal(3)malignant brain tumor-like protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC091763, AC152953

  6. NM_001408259.1 → NP_001395188.1  lethal(3)malignant brain tumor-like protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC091763, AC152953

  7. NM_172787.4 → NP_766375.1  lethal(3)malignant brain tumor-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_766375.1

    Status: VALIDATED

    Source sequence(s)
    AC091763, AC152953
    Consensus CDS
    CCDS23756.1
    UniProtKB/Swiss-Prot
    Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4
    Related
    ENSMUSP00000133479.2, ENSMUST00000174766.2
    Conserved Domains (3) summary
    cd09582
    Location:808 → 873
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:451 → 543
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:558 → 586
    zf-C2HC; Zinc finger, C2HC type

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    26150361..26252426 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155774.1 → XP_036011667.1  lethal(3)malignant brain tumor-like protein 3 isoform X4

    Conserved Domains (2) summary
    cd09582
    Location:732 → 797
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:375 → 467
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  2. XM_030245082.2 → XP_030100942.1  lethal(3)malignant brain tumor-like protein 3 isoform X3

    Conserved Domains (2) summary
    cd09582
    Location:757 → 822
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:400 → 492
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  3. XM_036155772.1 → XP_036011665.1  lethal(3)malignant brain tumor-like protein 3 isoform X2

    Conserved Domains (2) summary
    cd09582
    Location:783 → 848
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:426 → 518
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  4. XM_006512733.4 → XP_006512796.1  lethal(3)malignant brain tumor-like protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006512796.1

    UniProtKB/Swiss-Prot
    Q0VGT0, Q641L7, Q6ZPI2, Q8BLB7, Q8C0G4
    Conserved Domains (3) summary
    cd09582
    Location:808 → 873
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:451 → 543
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
    pfam01530
    Location:558 → 586
    zf-C2HC; Zinc finger, C2HC type

  5. XM_030245083.2 → XP_030100943.1  lethal(3)malignant brain tumor-like protein 3 isoform X4

    Conserved Domains (2) summary
    cd09582
    Location:732 → 797
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:375 → 467
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2

  6. XM_030245081.2 → XP_030100941.1  lethal(3)malignant brain tumor-like protein 3 isoform X2

    Conserved Domains (2) summary
    cd09582
    Location:783 → 848
    SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
    smart00561
    Location:426 → 518
    MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLB7.1 GenPept UniProtKB/Swiss-Prot:Q8BLB7

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