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Ppef1 protein phosphatase with EF hand calcium-binding domain 1 [ Mus musculus (house mouse) ]

Gene ID: 237178, updated on 28-Oct-2024

Summary

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Official Symbol
Ppef1provided by MGI
Official Full Name
protein phosphatase with EF hand calcium-binding domain 1provided by MGI
Primary source
MGI:MGI:1097157
See related
Ensembl:ENSMUSG00000062168 AllianceGenome:MGI:1097157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PPEF-1
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in detection of stimulus involved in sensory perception. Predicted to be active in cytosol and nucleus. Is expressed in ear and nervous system. Orthologous to human PPEF1 (protein phosphatase with EF-hand domain 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 1.6), CNS E14 (RPKM 0.1) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Ppef1 in Genome Data Viewer
Location:
X F4; X 73.95 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (159404997..159534286, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (160622419..160751290, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor G2 Neighboring gene predicted gene 15241 Neighboring gene phosphorylase kinase alpha 2 Neighboring gene STARR-seq mESC enhancer starr_48183 Neighboring gene STARR-seq mESC enhancer starr_48184 Neighboring gene nuclear encoded tRNA valine 3 (anticodon TAC) Neighboring gene STARR-seq mESC enhancer starr_48186 Neighboring gene retinoschisis (X-linked, juvenile) 1 (human) Neighboring gene cyclin dependent kinase like 5 Neighboring gene gap junction protein, alpha 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility. Lavoie-Ouellet C, et al. Mol Reprod Dev, 2021 Apr. PMID 33783058
  2. Drosophila-related expressed sequences. Banfi S, et al. Hum Mol Genet, 1997. PMID 9300667
  3. Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C. Sherman PM, et al. Proc Natl Acad Sci U S A, 1997 Oct 14. PMID 9326663, Free PMC Article
  4. Normal light response, photoreceptor integrity, and rhodopsin dephosphorylation in mice lacking both protein phosphatases with EF hands (PPEF-1 and PPEF-2). Ramulu P, et al. Mol Cell Biol, 2001 Dec. PMID 11713293, Free PMC Article
  5. A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin. Montini E, et al. Hum Mol Genet, 1997 Jul. PMID 9215685

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility.
    Title: The protein phosphatase with EF-hand domain 1 is a calmodulin-binding protein that interacts with proteins involved in sperm capacitation, binding to the zona pellucida, and motility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of stimulus involved in sensory perception IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase with EF-hands 1
Names
DRES10
PPEF 1
protein phosphatase with EF calcium-binding domain
NP_035277.1
XP_011246120.1
XP_017173969.1
XP_017173970.1
XP_030107195.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011147.1 → NP_035277.1  serine/threonine-protein phosphatase with EF-hands 1

    See identical proteins and their annotated locations for NP_035277.1

    Status: VALIDATED

    Source sequence(s)
    AL732450, AL974311
    Consensus CDS
    CCDS41200.1
    UniProtKB/Swiss-Prot
    A2AIC6, O35655
    Related
    ENSMUSP00000071191.6, ENSMUST00000071204.12
    Conserved Domains (4) summary
    smart00156
    Location:137 → 456
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd00051
    Location:571 → 636
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd07420
    Location:118 → 453
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
    pfam13499
    Location:575 → 636
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    159404997..159534286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251335.2 → XP_030107195.1  serine/threonine-protein phosphatase with EF-hands 1 isoform X3

    Conserved Domains (3) summary
    PTZ00183
    Location:436 → 578
    PTZ00183; centrin; Provisional
    cd07420
    Location:62 → 397
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
    pfam13499
    Location:513 → 581
    EF-hand_7; EF-hand domain pair

  2. XM_017318481.2 → XP_017173970.1  serine/threonine-protein phosphatase with EF-hands 1 isoform X2

    Conserved Domains (3) summary
    PTZ00183
    Location:497 → 639
    PTZ00183; centrin; Provisional
    cd07420
    Location:123 → 458
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
    pfam13499
    Location:574 → 642
    EF-hand_7; EF-hand domain pair

  3. XM_017318480.2 → XP_017173969.1  serine/threonine-protein phosphatase with EF-hands 1 isoform X1

    Conserved Domains (3) summary
    PTZ00183
    Location:518 → 660
    PTZ00183; centrin; Provisional
    cd07420
    Location:144 → 479
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
    pfam13499
    Location:595 → 663
    EF-hand_7; EF-hand domain pair

  4. XM_011247818.2 → XP_011246120.1  serine/threonine-protein phosphatase with EF-hands 1 isoform X1

    See identical proteins and their annotated locations for XP_011246120.1

    Conserved Domains (3) summary
    PTZ00183
    Location:518 → 660
    PTZ00183; centrin; Provisional
    cd07420
    Location:144 → 479
    MPP_RdgC; Drosophila melanogaster RdgC and related proteins, metallophosphatase domain
    pfam13499
    Location:595 → 663
    EF-hand_7; EF-hand domain pair
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35655.2 GenPept UniProtKB/Swiss-Prot:O35655

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