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Slc9a7 solute carrier family 9 (sodium/hydrogen exchanger), member 7 [ Mus musculus (house mouse) ]

Gene ID: 236727, updated on 18-Sep-2024

Summary

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Official Symbol
Slc9a7provided by MGI
Official Full Name
solute carrier family 9 (sodium/hydrogen exchanger), member 7provided by MGI
Primary source
MGI:MGI:2444530
See related
Ensembl:ENSMUSG00000037341 AllianceGenome:MGI:2444530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NHE7; 6330509M05Rik; A530087D17Rik
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of Golgi lumen acidification; and sodium ion import across plasma membrane. Predicted to act upstream of or within potassium ion transport. Predicted to be located in recycling endosome membrane and trans-Golgi network. Predicted to be integral component of membrane. Predicted to be active in plasma membrane and recycling endosome. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 108. Orthologous to human SLC9A7 (solute carrier family 9 member A7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 6.3), CNS E18 (RPKM 4.0) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Slc9a7 in Genome Data Viewer
Location:
X; X A1.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (19965090..20158274, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (20098851..20292035, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36, pseudogene 10 Neighboring gene STARR-seq mESC enhancer starr_46872 Neighboring gene STARR-seq mESC enhancer starr_46873 Neighboring gene predicted gene 5384 Neighboring gene STARR-seq mESC enhancer starr_46874 Neighboring gene carbohydrate sulfotransferase 7 Neighboring gene 40S ribosomal protein SA pseudogene Neighboring gene STARR-seq mESC enhancer starr_46875 Neighboring gene STARR-positive B cell enhancer ABC_E11046 Neighboring gene transcription initiation factor IIA subunit 1-like Neighboring gene high mobility group box 2 pseudogene Neighboring gene retinitis pigmentosa 2 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Four Na+/H+ exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. Nakamura N, et al. J Biol Chem, 2005 Jan 14. PMID 15522866
  2. The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease. Willnow T, et al. Organogenesis, 2005 Apr. PMID 19521566, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma.
    Title: NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium:proton antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of Golgi lumen acidification ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Golgi lumen acidification ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pH ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of pH ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
sodium/hydrogen exchanger 7
Names
Na(+)/H(+) exchanger 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177353.4 → NP_796327.1  sodium/hydrogen exchanger 7

    See identical proteins and their annotated locations for NP_796327.1

    Status: VALIDATED

    Source sequence(s)
    AL663098
    Consensus CDS
    CCDS40884.1
    UniProtKB/Swiss-Prot
    A2ACD5, A2ACD6, Q8BLV3
    Related
    ENSMUSP00000072274.5, ENSMUST00000072451.11
    Conserved Domains (1) summary
    TIGR00840
    Location:93 → 552
    b_cpa1; sodium/hydrogen exchanger 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    19965090..20158274 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527617.4 → XP_006527680.1  sodium/hydrogen exchanger 7 isoform X2

    Conserved Domains (1) summary
    TIGR00840
    Location:93 → 595
    b_cpa1; sodium/hydrogen exchanger 3

  2. XM_006527616.4 → XP_006527679.1  sodium/hydrogen exchanger 7 isoform X1

    See identical proteins and their annotated locations for XP_006527679.1

    UniProtKB/Swiss-Prot
    A2ACD5, A2ACD6, Q8BLV3
    Conserved Domains (1) summary
    TIGR00840
    Location:93 → 552
    b_cpa1; sodium/hydrogen exchanger 3

  3. XM_030251315.1 → XP_030107175.1  sodium/hydrogen exchanger 7 isoform X2

    Conserved Domains (1) summary
    TIGR00840
    Location:93 → 595
    b_cpa1; sodium/hydrogen exchanger 3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BLV3.1 GenPept UniProtKB/Swiss-Prot:Q8BLV3

Gene LinkOut

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