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PLXNB2 plexin B2 [ Homo sapiens (human) ]

Gene ID: 23654, updated on 11-Apr-2024

Summary

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Official Symbol
PLXNB2provided by HGNC
Official Full Name
plexin B2provided by HGNC
Primary source
HGNC:HGNC:9104
See related
Ensembl:ENSG00000196576 MIM:604293; AllianceGenome:HGNC:9104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MM1; PLEXB2; lncFAL; Nbla00445; dJ402G11.3
Summary
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in kidney (RPKM 34.6), spleen (RPKM 29.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See PLXNB2 in Genome Data Viewer
Location:
22q13.33
Exon count:
47
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50274979..50307646, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50781981..50815405, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50713408..50746075, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50697131-50697703 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50698428-50698928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13961 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50700498-50701229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13964 Neighboring gene mitogen-activated protein kinase 12 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50710106-50710645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50710646-50711186 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13968 Neighboring gene mitogen-activated protein kinase 11 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:50720546-50721745 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50738869-50739425 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50739426-50739982 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13970 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr22:50743729-50744928 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:50745236-50745386 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13972 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13971 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13973 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19314 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50753063-50753811 Neighboring gene uncharacterized LOC105373096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50755814-50756314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50756315-50756815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50759389-50759889 Neighboring gene DENN domain containing 6B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13975 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:50770723-50770912 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50780464-50781110 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13976 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13977 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13978 Neighboring gene protein phosphatase 6 regulatory subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19318 Neighboring gene RNA, 7SL, cytoplasmic 500, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion. Junqueira Alves C, et al. Nat Commun, 2021 Oct 14. PMID 34650052, Free PMC Article
  2. Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics. Huang Y, et al. Commun Biol, 2021 Jan 29. PMID 33514835, Free PMC Article
  3. Plexin-B2 in psoriasis; a clinical and immunohistochemical study. Hemida AS, et al. J Immunoassay Immunochem, 2020 Jul 3. PMID 32186222
  4. Plexin-B2 promotes invasive growth of malignant glioma. Le AP, et al. Oncotarget, 2015 Mar 30. PMID 25762646, Free PMC Article
  5. Identification and partial sequence of a cDNA that is differentially expressed in human brain tumors. Shinoura N, et al. Cancer Lett, 1995 Mar 2. PMID 7889532

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor.
    Title: Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor.
  2. Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia.
    Title: Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia.
  3. CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.
    Title: CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.
  4. Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.
    Title: Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.
  5. Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding.
    Title: Increased airway epithelial cell-derived exosomes activate macrophage-mediated allergic inflammation via CD100 shedding.
  6. Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
    Title: Plexin-B2 orchestrates collective stem cell dynamics via actomyosin contractility, cytoskeletal tension and adhesion.
  7. Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
    Title: Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics.
  8. Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
    Title: Myeloid cells protect intestinal epithelial barrier integrity through the angiogenin/plexin-B2 axis.
  9. Plexin-B2 in psoriasis; a clinical and immunohistochemical study.
    Title: Plexin-B2 in psoriasis; a clinical and immunohistochemical study.
  10. Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly.
    Title: Plexin B2 Is a Regulator of Monocyte Apoptotic Cell Disassembly.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0315

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables semaphorin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables semaphorin receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in brain development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in excitatory synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neural tube closure ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in semaphorin-plexin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell surface HDA PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of semaphorin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
plexin-B2
Names
ferroptosis-associated lncRNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001376864.1 → NP_001363793.1  plexin-B2 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Conserved Domains (7) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1350 → 1883
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain

  2. NM_001376865.1 → NP_001363794.1  plexin-B2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:918 → 1004
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:826 → 917
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:782 → 822
    PSI; Plexin repeat
    pfam08337
    Location:1294 → 1827
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:1006 → 1116
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  3. NM_001376866.1 → NP_001363795.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592, CT010163
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Related
    ENSP00000409171.1, ENST00000449103.5
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  4. NM_001376867.1 → NP_001363796.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592, CT010163
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  5. NM_001376868.1 → NP_001363797.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592, CT010163
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  6. NM_001376869.1 → NP_001363798.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592, CT010163
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  7. NM_001376870.1 → NP_001363799.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  8. NM_001376871.1 → NP_001363800.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  9. NM_001376872.1 → NP_001363801.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  10. NM_001376873.1 → NP_001363802.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  11. NM_001376874.1 → NP_001363803.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  12. NM_001376875.1 → NP_001363804.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  13. NM_001376876.1 → NP_001363805.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  14. NM_001376877.1 → NP_001363806.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  15. NM_001376878.1 → NP_001363807.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  16. NM_001376879.1 → NP_001363808.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592, CT010163
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  17. NM_001376880.1 → NP_001363809.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  18. NM_001376881.1 → NP_001363810.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  19. NM_001376882.1 → NP_001363811.1  plexin-B2 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  20. NM_001376883.1 → NP_001363812.1  plexin-B2 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1263 → 1796
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  21. NM_001376884.1 → NP_001363813.1  plexin-B2 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd12792
    Location:1271 → 1811
    RasGAP_plexin_B2; Ras-GTPase Activating Domain of plexin-B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  22. NM_001376885.1 → NP_001363814.1  plexin-B2 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592, CT010163
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd12792
    Location:1271 → 1811
    RasGAP_plexin_B2; Ras-GTPase Activating Domain of plexin-B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  23. NM_001376886.1 → NP_001363815.1  plexin-B2 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AL022328, BX649592, CT010163
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:864 → 950
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:772 → 863
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:728 → 768
    PSI; Plexin repeat
    pfam08337
    Location:1240 → 1773
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:952 → 1062
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

  24. NM_012401.4 → NP_036533.2  plexin-B2 isoform 3 precursor

    See identical proteins and their annotated locations for NP_036533.2

    Status: VALIDATED

    Source sequence(s)
    AB002313, AL022328, BC000221, BX649592, CT010163
    Consensus CDS
    CCDS43035.1
    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7
    Related
    ENSP00000352288.4, ENST00000359337.9
    Conserved Domains (8) summary
    cd11276
    Location:27 → 467
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    smart00423
    Location:468 → 518
    PSI; domain found in Plexins, Semaphorins and Integrins
    cd01179
    Location:895 → 981
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:803 → 894
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:759 → 799
    PSI; Plexin repeat
    pfam08337
    Location:1271 → 1804
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:526 → 613
    TIG_plexin; TIG domain
    cl15674
    Location:983 → 1093
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50274979..50307646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441264.1 → XP_047297220.1  plexin-B2 isoform X2

    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7

  2. XM_011530682.3 → XP_011528984.1  plexin-B2 isoform X1

    Conserved Domains (6) summary
    cd11276
    Location:90 → 530
    Sema_plexin_B2; The Sema domain, a protein interacting module, of Plexin B2
    cd01179
    Location:958 → 1044
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:866 → 957
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:532 → 580
    PSI; Plexin repeat
    pfam01833
    Location:1046 → 1154
    TIG; IPT/TIG domain
    pfam08337
    Location:1334 → 1868
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain

  3. XM_047441263.1 → XP_047297219.1  plexin-B2 isoform X2

    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7

  4. XM_047441262.1 → XP_047297218.1  plexin-B2 isoform X2

    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7

  5. XM_047441261.1 → XP_047297217.1  plexin-B2 isoform X2

    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7

  6. XM_047441266.1 → XP_047297222.1  plexin-B2 isoform X4

    Related
    ENST00000479701.5

  7. XM_047441265.1 → XP_047297221.1  plexin-B2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50781981..50815405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325401.1 → XP_054181376.1  plexin-B2 isoform X2

    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7

  2. XM_054325399.1 → XP_054181374.1  plexin-B2 isoform X1

  3. XM_054325402.1 → XP_054181377.1  plexin-B2 isoform X2

    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7

  4. XM_054325400.1 → XP_054181375.1  plexin-B2 isoform X2

    UniProtKB/Swiss-Prot
    A6QRH0, O15031, Q7KZU3, Q9BSU7

  5. XM_054325404.1 → XP_054181379.1  plexin-B2 isoform X4

  6. XM_054325403.1 → XP_054181378.1  plexin-B2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O15031.3 GenPept UniProtKB/Swiss-Prot:O15031

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