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CARHSP1 calcium regulated heat stable protein 1 [ Homo sapiens (human) ]

Gene ID: 23589, updated on 7-Apr-2024

Summary

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Official Symbol
CARHSP1provided by HGNC
Official Full Name
calcium regulated heat stable protein 1provided by HGNC
Primary source
HGNC:HGNC:17150
See related
Ensembl:ENSG00000153048 MIM:616885; AllianceGenome:HGNC:17150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSDC1; CRHSP24; CRHSP-24
Summary
Enables mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule and cytosol. Predicted to be active in cytoplasm. Predicted to colocalize with cytoplasmic exosome (RNase complex). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 17.9), adrenal (RPKM 11.8) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (8852942..8869006, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (8885694..8901743, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (8946799..8962863, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903642 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891090-8891784 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8891785-8892479 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7178 Neighboring gene transmembrane protein 186 Neighboring gene phosphomannomutase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7180 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8923335-8923936 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8929774-8930308 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8930309-8930841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8940347-8940938 Neighboring gene uncharacterized LOC100130283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10354 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:8953773-8954487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10355 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8959743-8960380 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:8960381-8961020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10356 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7181 Neighboring gene CARHSP1 divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr16:8971783-8971898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10357 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:8976345-8976845 Neighboring gene LITAF domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma. Zhu GD, et al. Cell Death Dis, 2021 Jul 21. PMID 34290231, Free PMC Article
  2. Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response. Hou H, et al. J Biol Chem, 2011 Mar 18. PMID 21177848, Free PMC Article
  3. Purification and characterization of a novel physiological substrate for calcineurin in mammalian cells. Groblewski GE, et al. J Biol Chem, 1998 Aug 28. PMID 9712905
  4. miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1. Li X, et al. Sci Rep, 2016 Feb 22. PMID 26899994, Free PMC Article
  5. Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor α. Fan Y, et al. J Biol Chem, 2011 Nov 25. PMID 21990353, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma.
    Title: Genome-wide CRISPR/Cas9 screening identifies CARHSP1 responsible for radiation resistance in glioblastoma.
  2. Increased miR-155 relieves chronic inflammation by a negative feedback loop and plays a protective role during atherosclerosis-associated foam cell formation by signaling through the miR-155-CARHSP1-TNF-alpha pathway.
    Title: miR-155 acts as an anti-inflammatory factor in atherosclerosis-associated foam cell formation by repressing calcium-regulated heat stable protein 1.
  3. CARHSP1 inhibits hepatic gluconeogenic gene expression via repression of PPARalpha
    Title: Inhibition of gluconeogenic genes by calcium-regulated heat-stable protein 1 via repression of peroxisome proliferator-activated receptor α.
  4. CRHSP-24 participates in oxidative stress response via a dynamic and temporal association between stress granules and processing bodies.
    Title: Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response.
  5. Data suggest that CARHSP1 is a TNF-alpha mRNA stability enhancer required for effective TNF-alpha production, demonstrating the importance of both stabilization and destabilization pathways in regulating the TNF-alpha mRNA half-life.
    Title: CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111446

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of mRNA stability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mRNA stability ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in P granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in P-body IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic exosome (RNase complex) ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
calcium-regulated heat-stable protein 1
Names
calcium regulated heat stable protein 1, 24kDa
calcium-regulated heat-stable protein (24kD)
calcium-regulated heat-stable protein of 24 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042476.2 → NP_001035941.1  calcium-regulated heat-stable protein 1

    See identical proteins and their annotated locations for NP_001035941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AC022167, BC001333, BQ004670, HY090855
    Consensus CDS
    CCDS10537.1
    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Related
    ENSP00000379838.2, ENST00000396593.6
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  2. NM_001278260.2 → NP_001265189.1  calcium-regulated heat-stable protein 1

    See identical proteins and their annotated locations for NP_001265189.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AC022167
    Consensus CDS
    CCDS10537.1
    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Related
    ENSP00000481550.1, ENST00000611932.4
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  3. NM_001278261.2 → NP_001265190.1  calcium-regulated heat-stable protein 1

    See identical proteins and their annotated locations for NP_001265190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AC022167
    Consensus CDS
    CCDS10537.1
    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Related
    ENSP00000483591.1, ENST00000618335.4
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  4. NM_001278262.2 → NP_001265191.1  calcium-regulated heat-stable protein 1

    See identical proteins and their annotated locations for NP_001265191.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AC022167
    Consensus CDS
    CCDS10537.1
    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Related
    ENSP00000480542.1, ENST00000614449.4
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  5. NM_001278263.1 → NP_001265192.1  calcium-regulated heat-stable protein 1

    See identical proteins and their annotated locations for NP_001265192.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AC022167, BM920489, BQ004670, HY090855
    Consensus CDS
    CCDS10537.1
    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Related
    ENSP00000455284.1, ENST00000561530.5
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  6. NM_001278264.2 → NP_001265193.1  calcium-regulated heat-stable protein 1

    See identical proteins and their annotated locations for NP_001265193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AC022167
    Consensus CDS
    CCDS10537.1
    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Related
    ENSP00000480144.1, ENST00000619881.4
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  7. NM_001278265.2 → NP_001265194.1  calcium-regulated heat-stable protein 1

    See identical proteins and their annotated locations for NP_001265194.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AC022167
    Consensus CDS
    CCDS10537.1
    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Related
    ENSP00000478055.1, ENST00000610831.4
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  8. NM_001278266.2 → NP_001265195.1  calcium-regulated heat-stable protein 1

    See identical proteins and their annotated locations for NP_001265195.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-9 encode the same protein.
    Source sequence(s)
    AC022167
    Consensus CDS
    CCDS10537.1
    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Related
    ENSP00000455855.1, ENST00000567554.5
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  9. NM_014316.4 → NP_055131.2  calcium-regulated heat-stable protein 1

    See identical proteins and their annotated locations for NP_055131.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. Variants 1-9 encode the same protein.
    Source sequence(s)
    AC022167
    Consensus CDS
    CCDS10537.1
    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Related
    ENSP00000311847.4, ENST00000311052.10
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    8852942..8869006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522444.3 → XP_011520746.1  calcium-regulated heat-stable protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011520746.1

    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
    UniProtKB/TrEMBL
    H3BNU9
    Conserved Domains (1) summary
    cd04458
    Location:63 → 128
    CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...

  2. XM_047433886.1 → XP_047289842.1  calcium-regulated heat-stable protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

  3. XM_047433884.1 → XP_047289840.1  calcium-regulated heat-stable protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

  4. XM_047433885.1 → XP_047289841.1  calcium-regulated heat-stable protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    8885694..8901743 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379981.1 → XP_054235956.1  calcium-regulated heat-stable protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

  2. XM_054379982.1 → XP_054235957.1  calcium-regulated heat-stable protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

  3. XM_054379980.1 → XP_054235955.1  calcium-regulated heat-stable protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2

  4. XM_054379983.1 → XP_054235958.1  calcium-regulated heat-stable protein 1 isoform X1

    UniProtKB/Swiss-Prot
    B2R4C3, D3DUF5, Q2YDX5, Q9BQ53, Q9Y2V2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2V2.2 GenPept UniProtKB/Swiss-Prot:Q9Y2V2

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