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CHST5 carbohydrate sulfotransferase 5 [ Homo sapiens (human) ]

Gene ID: 23563, updated on 5-Mar-2024

Summary

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Official Symbol
CHST5provided by HGNC
Official Full Name
carbohydrate sulfotransferase 5provided by HGNC
Primary source
HGNC:HGNC:1973
See related
Ensembl:ENSG00000135702 MIM:604817; AllianceGenome:HGNC:1973
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
gn6st-3; hIGn6ST; I-GlcNAc6ST; glcNAc6ST-3; I-GlcNAc-6-ST
Summary
The protein encoded by this gene belongs to the Gal/GalNAc/GlcNAc 6-O-sulfotransferase (GST) family, members of which catalyze the transfer of sulfate to position 6 of galactose (Gal), N-acetylgalactosamine (GalNAc), or N-acetylglucosamine (GlcNAc) residues within proteoglycans, and sulfation of O-linked sugars of mucin-type acceptors. Carbohydrate sulfation plays a critical role in many biologic processes. This gene is predominantly expressed in colon and small intestine. [provided by RefSeq, Aug 2011]
Expression
Biased expression in colon (RPKM 16.2), duodenum (RPKM 16.2) and 2 other tissues See more
Orthologs
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Genomic context

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See CHST5 in Genome Data Viewer
Location:
16q23.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (75528530..75536108, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (81576783..81584361, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (75562428..75570006, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:75505547-75506189 Neighboring gene carbohydrate sulfotransferase 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11132 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11134 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7721 Neighboring gene TMEM231 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7722 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7723 Neighboring gene transmembrane protein 231 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7724 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11138 Neighboring gene Sharpr-MPRA regulatory region 12601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:75600739-75601492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11139 Neighboring gene GABA type A receptor associated protein like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7727

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications. Lee JK, et al. Glycobiology, 2003 Apr. PMID 12626414
  2. Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma. Seko A, et al. Glycobiology, 2002 Jun. PMID 12107080
  3. Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene. Akama TO, et al. Nat Genet, 2000 Oct. PMID 11017086
  4. Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis. Yu SY, et al. J Biol Chem, 2018 Sep 28. PMID 30093410, Free PMC Article
  5. Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta). Bartes A, et al. Biochem Biophys Res Commun, 2001 Apr 13. PMID 11352640

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. mRNA transcript analyses on the genes involved in synthesizing GlcNAc-6-O-sulfated glycans in human colon cancer tissues indicated that GlcNAc6ST-2 (CHST4) is preferentially expressed in cancer cells ... GlcNAc6ST-3 (CHST5) was only expressed in nonmalignant epithelial cells, whereas GlcNAc6ST-1 (CHST2) was expressed equally in both
    Title: Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry-based sulfoglycomic analysis.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: A Large-scale genetic association study of esophageal adenocarcinoma risk.
  3. sulfated keratan sulfate is produced by beta3GNT7, beta4GalT4, CGn6ST, and KSG6ST
    Title: Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Sulfate is linked to the carbohydrate chains of HIV-1 glycoproteins gp160, gp120, and gp41 during the endoplasmic reticulum to Golgi transport of the glycoproteins PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC74625

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosamine 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acetylglucosamine 6-O-sulfotransferase activity TAS
Traceable Author Statement
more info
  
enables sulfotransferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylglucosamine metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in keratan sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
  
involved_in protein sulfation TAS
Traceable Author Statement
more info
 PubMed 
involved_in sulfur compound metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carbohydrate sulfotransferase 5
Names
GST4-alpha
N-acetylglucosamine 6-O-sulfotransferase 3
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-alpha
intestinal GlcNAc-6-sulfotransferase
NP_078809.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029853.1 RefSeqGene

    Range
    4063..11641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024533.5 → NP_078809.2  carbohydrate sulfotransferase 5

    See identical proteins and their annotated locations for NP_078809.2

    Status: REVIEWED

    Source sequence(s)
    AC009163
    Consensus CDS
    CCDS10919.1
    UniProtKB/Swiss-Prot
    B2RV23, Q7LCN3, Q9GZS9, Q9UBY3
    Related
    ENSP00000338783.3, ENST00000336257.8
    Conserved Domains (1) summary
    pfam13469
    Location:65 → 319
    Sulfotransfer_3; Sulfotransferase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    75528530..75536108 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    81576783..81584361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_012126.1: Suppressed sequence

    Description
    NM_012126.1: This RefSeq was permanently suppressed because it was based on a rare read-through transcript that has insufficient support.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GZS9.3 GenPept UniProtKB/Swiss-Prot:Q9GZS9

Gene LinkOut

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