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MORC3 MORC family CW-type zinc finger 3 [ Homo sapiens (human) ]

Gene ID: 23515, updated on 14-Nov-2024

Summary

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Official Symbol
MORC3provided by HGNC
Official Full Name
MORC family CW-type zinc finger 3provided by HGNC
Primary source
HGNC:HGNC:23572
See related
Ensembl:ENSG00000159256 MIM:610078; AllianceGenome:HGNC:23572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NXP2; ZCW5; ZCWCC3
Summary
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
Expression
Ubiquitous expression in bone marrow (RPKM 15.2), ovary (RPKM 12.6) and 25 other tissues See more
Orthologs
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Genomic context

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See MORC3 in Genome Data Viewer
Location:
21q22.12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (36320197..36376632)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (34702785..34759216)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (37692495..37748930)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr21:37668114-37668355 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:37679355-37679926 Neighboring gene serine and arginine rich splicing factor 9 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13284 Neighboring gene ribosomal protein S26 pseudogene 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:37708895-37710094 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:37737075-37737251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13285 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37758141-37758642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37758643-37759142 Neighboring gene ATP synthase membrane subunit f pseudogene 1 Neighboring gene chromatin assembly factor 1 subunit B Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:37780832-37782031 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37802462-37803337 Neighboring gene CLDN14 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:37836794-37837391 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:37842779-37843278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18436 Neighboring gene claudin 14 Neighboring gene proteasome 26S subunit, non-ATPase 4 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients. Rogers A, et al. Arthritis Care Res (Hoboken), 2017 Dec. PMID 28129490, Free PMC Article
  2. En garde! The duel functions of MORC3. Fox LE, et al. Cell Host Microbe, 2022 Jan 12. PMID 35026136
  3. Self-guarding of MORC3 enables virulence factor-triggered immunity. Gaidt MM, et al. Nature, 2021 Dec. PMID 34759314, Free PMC Article
  4. Anti-MJ/NXP-2 autoantibody specificity in a cohort of adult Italian patients with polymyositis/dermatomyositis. Ceribelli A, et al. Arthritis Res Ther, 2012 Apr 30. PMID 22546500, Free PMC Article
  5. Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancy. Ichimura Y, et al. Ann Rheum Dis, 2012 May. PMID 22258483

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies.
    Title: MORC3 represses the HCMV major immediate early promoter in myeloid cells in the absence of PML nuclear bodies.
  2. MORC3 restricts human cytomegalovirus infection by suppressing the major immediate-early promoter activity.
    Title: MORC3 restricts human cytomegalovirus infection by suppressing the major immediate-early promoter activity.
  3. En garde! The duel functions of MORC3.
    Title: En garde! The duel functions of MORC3.
  4. Self-guarding of MORC3 enables virulence factor-triggered immunity.
    Title: Self-guarding of MORC3 enables virulence factor-triggered immunity.
  5. Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation.
    Title: Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation.
  6. Data show that MORC family CW-type zinc finger 3 (MORC3) ATPase is a new target of NS1 protein, influenza A virus (NS1) from H3N2-subtype influenza virus.
    Title: MORC3 Is a Target of the Influenza A Viral Protein NS1.
  7. Mechanism for autoinhibition and activation
    Title: Mechanism for autoinhibition and activation of the MORC3 ATPase.
  8. our studies provide a molecular framework detailing MORC3 functions and suggest that its modulation may contribute to human disease.
    Title: Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.
  9. Dermatomyositis patients with anti-NXP-2 antibodies have a distinct and often severe systemic phenotype that includes myalgia, peripheral edema, and significant dysphagia, despite having milder inflammatory skin disease.
    Title: Cutaneous and Systemic Findings Associated With Nuclear Matrix Protein 2 Antibodies in Adult Dermatomyositis Patients.
  10. MORC3 has antiviral activity during herpes simplex virus 1 and human cytomegalovirus infections.
    Title: MORC3, a Component of PML Nuclear Bodies, Has a Role in Restricting Herpes Simplex Virus 1 and Human Cytomegalovirus.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antiviral innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within maintenance of protein location in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within maintenance of protein location in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of cellular senescence IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MORC family CW-type zinc finger protein 3
Names
nuclear matrix protein 2
nuclear matrix protein NXP2
zinc finger CW-type coiled-coil domain protein 3
zinc finger, CW type with coiled-coil domain 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320445.2 → NP_001307374.1  MORC family CW-type zinc finger protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
    Source sequence(s)
    AK295133, BC144116, BM786077
    UniProtKB/TrEMBL
    A2RU29, B4DHJ4, Q4VBZ9
    Related
    ENST00000487909.5
    Conserved Domains (4) summary
    COG1196
    Location:602 → 796
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07496
    Location:338 → 375
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:178 → 311
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    cl00075
    Location:1 → 64
    HATPase; Histidine kinase-like ATPase domain

  2. NM_001320446.2 → NP_001307375.1  MORC family CW-type zinc finger protein 3 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon compared to variant 1. This variant represents translation initiation at a downstream AUG compared to variant 1; the 5'-most initiation codon, as used in variant 1, is associated with a truncated ORF that would render the transcript a candidate for nonsense-mediated decay (NMD). Leaky scanning may allow translation initiation at the downstream AUG to encode an isoform (2) that has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein (isoform 2).
    Source sequence(s)
    BC144116, BM786077, DA434361
    UniProtKB/TrEMBL
    A2RU29, B4DHJ4, Q4VBZ9
    Conserved Domains (4) summary
    COG1196
    Location:602 → 796
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam07496
    Location:338 → 375
    zf-CW; CW-type Zinc Finger
    pfam17942
    Location:178 → 311
    Morc6_S5; Morc6 ribosomal protein S5 domain 2-like
    cl00075
    Location:1 → 64
    HATPase; Histidine kinase-like ATPase domain

  3. NM_015358.3 → NP_056173.1  MORC family CW-type zinc finger protein 3 isoform 1

    See identical proteins and their annotated locations for NP_056173.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    BC094779, D50926, DA702537
    Consensus CDS
    CCDS42924.1
    UniProtKB/Swiss-Prot
    A8KA92, Q14149, Q9UEZ2
    UniProtKB/TrEMBL
    A2RU29, Q4VBZ9
    Related
    ENSP00000383333.1, ENST00000400485.6
    Conserved Domains (3) summary
    pfam07496
    Location:409 → 446
    zf-CW; CW-type Zinc Finger
    pfam16515
    Location:769 → 861
    HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    cl00075
    Location:29 → 127
    HATPase_c; Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    36320197..36376632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    34702785..34759216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14149.3 GenPept UniProtKB/Swiss-Prot:Q14149

Gene LinkOut

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