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BICRAL BICRA like chromatin remodeling complex associated protein [ Homo sapiens (human) ]

Gene ID: 23506, updated on 5-Mar-2024

Summary

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Official Symbol
BICRALprovided by HGNC
Official Full Name
BICRA like chromatin remodeling complex associated proteinprovided by HGNC
Primary source
HGNC:HGNC:21111
See related
Ensembl:ENSG00000112624 MIM:618502; AllianceGenome:HGNC:21111
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SMARCK2; GLTSCR1L; KIAA0240
Summary
Predicted to be involved in positive regulation of transcription, DNA-templated. Part of SWI/SNF complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 8.6), thyroid (RPKM 7.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
6p21.1
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (42746339..42868556)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42575724..42697274)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (42714725..42836294)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATPase H+ transporting V0 subunit c pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:42713934-42714897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24569 Neighboring gene putative uncharacterized protein encoded by LINC00269 Neighboring gene tubulin folding cofactor C Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24570 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42750599-42751288 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:42751289-42751978 Neighboring gene uncharacterized LOC401261 Neighboring gene MPRA-validated peak5810 silencer Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr6:42846366-42847323 and GRCh37_chr6:42847324-42848280 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24575 Neighboring gene ribosomal protein L7 like 1 Neighboring gene chromosome 6 open reading frame 226

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A non-canonical BRD9-containing BAF chromatin remodeling complex regulates naive pluripotency in mouse embryonic stem cells. Gatchalian J, et al. Nat Commun, 2018 Dec 3. PMID 30510198, Free PMC Article
  2. Glioma tumor suppressor candidate region gene 1 (GLTSCR1) and its paralog GLTSCR1-like form SWI/SNF chromatin remodeling subcomplexes. Alpsoy A, et al. J Biol Chem, 2018 Mar 16. PMID 29374058, Free PMC Article
  3. Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. Nagase T, et al. DNA Res, 1996 Oct 31. PMID 9039502
  4. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. Nakayama M, et al. Genome Res, 2002 Nov. PMID 12421765, Free PMC Article
  5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0240, DKFZp686P0250

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of GBAF complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SWI/SNF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
BRD4-interacting chromatin-remodeling complex-associated protein-like
Names
BRD4 interacting chromatin remodeling complex associated protein like
BRD4 interacting chromatin remodelling complex associated protein like
GLTSCR1 like
glioma tumor suppressor candidate region gene 1 protein-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_054763.1 RefSeqGene

    Range
    40095..126599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318819.2 → NP_001305748.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL353716, AW168030, D87077
    Consensus CDS
    CCDS34451.1
    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
    Conserved Domains (1) summary
    pfam15249
    Location:711 → 811
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  2. NM_001393499.1 → NP_001380428.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

    Status: VALIDATED

    Source sequence(s)
    AL035587, AL353716
    Consensus CDS
    CCDS34451.1
    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
    Related
    ENSP00000313933.4, ENST00000314073.10
    Conserved Domains (1) summary
    pfam15249
    Location:711 → 811
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

  3. NM_015349.3 → NP_056164.1  BRD4-interacting chromatin-remodeling complex-associated protein-like

    See identical proteins and their annotated locations for NP_056164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK093526, AL833540, AW168030, BC015724, BC047630
    Consensus CDS
    CCDS34451.1
    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
    Related
    ENSP00000377723.1, ENST00000394168.1
    Conserved Domains (1) summary
    pfam15249
    Location:711 → 811
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    42746339..42868556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047418544.1 → XP_047274500.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

  2. XM_047418547.1 → XP_047274503.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X3

  3. XM_047418542.1 → XP_047274498.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

  4. XM_047418545.1 → XP_047274501.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

  5. XM_047418543.1 → XP_047274499.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X2

  6. XM_024446390.2 → XP_024302158.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514
    Conserved Domains (1) summary
    pfam15249
    Location:711 → 811
    GLTSCR1; Conserved region of unknown function on GLTSCR protein

RNA

  1. XR_007059228.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    42575724..42697274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054354967.1 → XP_054210942.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514

  2. XM_054354961.1 → XP_054210936.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514

  3. XM_054354962.1 → XP_054210937.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514

  4. XM_054354968.1 → XP_054210943.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514

  5. XM_054354964.1 → XP_054210939.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514

  6. XM_054354963.1 → XP_054210938.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514

  7. XM_054354965.1 → XP_054210940.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514

  8. XM_054354966.1 → XP_054210941.1  BRD4-interacting chromatin-remodeling complex-associated protein-like isoform X1

    UniProtKB/Swiss-Prot
    A1L3W2, Q5TFZ3, Q6AI39, Q92514

RNA

  1. XR_008487286.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AI39.2 GenPept UniProtKB/Swiss-Prot:Q6AI39

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