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Klhdc4 kelch domain containing 4 [ Mus musculus (house mouse) ]

Gene ID: 234825, updated on 2-Nov-2024

Summary

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Official Symbol
Klhdc4provided by MGI
Official Full Name
kelch domain containing 4provided by MGI
Primary source
MGI:MGI:2384569
See related
Ensembl:ENSMUSG00000040263 AllianceGenome:MGI:2384569
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G430025P05Rik
Summary
Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; and cerebral cortex ventricular layer. Orthologous to human KLHDC4 (kelch domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 12.5), CNS E14 (RPKM 9.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Klhdc4 in Genome Data Viewer
Location:
8 E1; 8 70.76 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (122523047..122556322, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (121796308..121829583, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46065 Neighboring gene junctophilin 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:124353433-124353616 Neighboring gene STARR-positive B cell enhancer ABC_E1774 Neighboring gene predicted gene, 24283 Neighboring gene STARR-seq mESC enhancer starr_22928 Neighboring gene predicted gene, 26812 Neighboring gene STARR-seq mESC enhancer starr_22929

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Wnt regulates amino acid transporter Slc7a5 and so constrains the integrated stress response in mouse embryos. Poncet N, et al. EMBO Rep, 2020 Jan 7. PMID 31789450, Free PMC Article
  2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC19372

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
kelch domain-containing protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145605.2 → NP_663580.2  kelch domain-containing protein 4

    See identical proteins and their annotated locations for NP_663580.2

    Status: VALIDATED

    Source sequence(s)
    AC121975, AK161674, AV374981, BY086869
    Consensus CDS
    CCDS22729.1
    UniProtKB/Swiss-Prot
    Q8CIK0, Q921I2
    UniProtKB/TrEMBL
    G3X961
    Related
    ENSMUSP00000043439.11, ENSMUST00000045884.17
    Conserved Domains (4) summary
    sd00038
    Location:64 → 115
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:431 → 480
    Kelch_1; Kelch motif
    pfam13415
    Location:75 → 127
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:174 → 216
    Kelch_5; Kelch motif

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    122523047..122556322 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248370.3 → XP_011246672.1  kelch domain-containing protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q8CIK0, Q921I2
    Conserved Domains (3) summary
    PLN02193
    Location:77 → 314
    PLN02193; nitrile-specifier protein
    sd00038
    Location:64 → 115
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:431 → 480
    Kelch_1; Kelch motif

  2. XM_006530947.4 → XP_006531010.1  kelch domain-containing protein 4 isoform X2

    UniProtKB/TrEMBL
    G3UZ63
    Conserved Domains (3) summary
    PLN02193
    Location:135 → 270
    PLN02193; nitrile-specifier protein
    sd00038
    Location:133 → 180
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:387 → 436
    Kelch_1; Kelch motif

  3. XM_006530948.5 → XP_006531011.1  kelch domain-containing protein 4 isoform X3

    See identical proteins and their annotated locations for XP_006531011.1

    UniProtKB/TrEMBL
    G3UZG5
    Related
    ENSMUSP00000134487.2, ENSMUST00000174192.2
    Conserved Domains (3) summary
    PLN02193
    Location:15 → 222
    PLN02193; nitrile-specifier protein
    sd00038
    Location:27 → 82
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:339 → 388
    Kelch_1; Kelch motif

  4. XM_006530950.5 → XP_006531013.1  kelch domain-containing protein 4 isoform X4

    Conserved Domains (3) summary
    PLN02193
    Location:47 → 182
    PLN02193; nitrile-specifier protein
    sd00038
    Location:45 → 92
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:299 → 348
    Kelch_1; Kelch motif

  5. XM_030243519.2 → XP_030099379.1  kelch domain-containing protein 4 isoform X3

    UniProtKB/TrEMBL
    G3UZG5
    Conserved Domains (3) summary
    PLN02193
    Location:15 → 222
    PLN02193; nitrile-specifier protein
    sd00038
    Location:27 → 82
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:339 → 388
    Kelch_1; Kelch motif

  6. XM_017312755.3 → XP_017168244.1  kelch domain-containing protein 4 isoform X5

    Conserved Domains (3) summary
    PLN02193
    Location:39 → 174
    PLN02193; nitrile-specifier protein
    sd00038
    Location:37 → 84
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:291 → 340
    Kelch_1; Kelch motif

  7. XM_006530952.5 → XP_006531015.1  kelch domain-containing protein 4 isoform X6

    Conserved Domains (3) summary
    PLN02193
    Location:4 → 79
    PLN02193; nitrile-specifier protein
    sd00038
    Location:2 → 54
    Kelch; KELCH repeat [structural motif]
    pfam01344
    Location:196 → 245
    Kelch_1; Kelch motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q921I2.2 GenPept UniProtKB/Swiss-Prot:Q921I2

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