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TRAM1 translocation associated membrane protein 1 [ Homo sapiens (human) ]

Gene ID: 23471, updated on 11-Apr-2024

Summary

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Official Symbol
TRAM1provided by HGNC
Official Full Name
translocation associated membrane protein 1provided by HGNC
Primary source
HGNC:HGNC:20568
See related
Ensembl:ENSG00000067167 MIM:605190; AllianceGenome:HGNC:20568
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRAM; PNAS8; TRAMP
Summary
This gene encodes a multi-pass membrane protein that is part of the mammalian endoplasmic reticulum. The encoded protein influences glycosylation and facilitates the translocation of secretory proteins across the endoplasmic reticulum membrane by regulating which domains of the nascent polypeptide chain are visible to the cytosol during a translocational pause. [provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in thyroid (RPKM 96.1), urinary bladder (RPKM 71.4) and 25 other tissues See more
Orthologs
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Genomic context

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See TRAM1 in Genome Data Viewer
Location:
8q13.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (70573218..70608416, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (71003150..71038323, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (71485453..71520651, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375890 Neighboring gene ribosomal protein L13 pseudogene 11 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:71453867-71454367 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19272 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19273 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19274 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19275 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27508 Neighboring gene LACTB2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27509 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27510 Neighboring gene lactamase beta 2 Neighboring gene RNA, 7SL, cytoplasmic 19, pseudogene Neighboring gene XK related 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:71660008-71660508 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27511 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:71716960-71717817 Neighboring gene uncharacterized LOC124901960

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The human TRAM1 locus expresses circular RNAs. Dubois J, et al. Sci Rep, 2021 Nov 11. PMID 34764360, Free PMC Article
  2. TRAM1 protect HepG2 cells from palmitate induced insulin resistance through ER stress-JNK pathway. Tang Z, et al. Biochem Biophys Res Commun, 2015 Feb 20. PMID 25600807
  3. TRAM1 is involved in disposal of ER membrane degradation substrates. Ng CL, et al. Exp Cell Res, 2010 Aug 1. PMID 20430023, Free PMC Article
  4. TRAM regulates the exposure of nascent secretory proteins to the cytosol during translocation into the endoplasmic reticulum. Hegde RS, et al. Cell, 1998 Mar 6. PMID 9506517
  5. Protein translocation. Travelling by TRAM. Walter P. Nature, 1992 May 7. PMID 1315419

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication.
    Title: The REEP5/TRAM1 complex binds SARS-CoV-2 NSP3 and promotes virus replication.
  2. Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog.
    Title: Identification of TRAMs as sphingolipid-binding proteins using a photoactivatable and clickable short-chain ceramide analog.
  3. The human TRAM1 locus expresses circular RNAs.
    Title: The human TRAM1 locus expresses circular RNAs.
  4. TRAM1 protect HepG2 cells from palmitate-induced insulin resistance. The protection of TRAM1 to HepG2 cells is through endoplasmic reticulum stress-JNK pathway.
    Title: TRAM1 protect HepG2 cells from palmitate induced insulin resistance through ER stress-JNK pathway.
  5. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
    Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Dengue hemorrhagic fever is associated with polymorphisms in JAK1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • PRO1292

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IEA
Inferred from Electronic Annotation
more info
  
involved_in cotranslational protein targeting to membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein insertion into ER membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to unfolded protein IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
translocating chain-associated membrane protein 1
Names
translocating chain-associating membrane protein
translocation-associating membrane protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317804.2 → NP_001304733.1  translocating chain-associated membrane protein 1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA740941, AC120194, AK303411, BC032018, BC037738, BQ233660, DB448315
    UniProtKB/TrEMBL
    Q6FHU7
    Conserved Domains (2) summary
    smart00724
    Location:86 → 295
    TLC; TRAM, LAG1 and CLN8 homology domains
    pfam08390
    Location:19 → 84
    TRAM1; TRAM1-like protein

  2. NM_001317805.2 → NP_001304734.1  translocating chain-associated membrane protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translation start site compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA740941, AC120194, AK303411, BC032018, BC037738, BQ233660
    Consensus CDS
    CCDS83300.1
    UniProtKB/TrEMBL
    G3XAN4
    Related
    ENSP00000428052.1, ENST00000521425.5
    Conserved Domains (2) summary
    smart00724
    Location:31 → 240
    TLC; TRAM, LAG1 and CLN8 homology domains
    pfam08390
    Location:1 → 29
    TRAM1; TRAM1-like protein

  3. NM_014294.6 → NP_055109.1  translocating chain-associated membrane protein 1 isoform 1

    See identical proteins and their annotated locations for NP_055109.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AA740941, AC120194, BC037738, BI465346, DB448315
    Consensus CDS
    CCDS6207.1
    UniProtKB/Swiss-Prot
    B4E0K2, Q15629
    UniProtKB/TrEMBL
    Q6FHL3, Q6FHU7
    Related
    ENSP00000262213.2, ENST00000262213.7
    Conserved Domains (2) summary
    smart00724
    Location:117 → 326
    TLC; TRAM, LAG1 and CLN8 homology domains
    pfam08390
    Location:50 → 115
    TRAM1; TRAM1-like protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    70573218..70608416 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421636.1 → XP_047277592.1  translocating chain-associated membrane protein 1 isoform X1

    UniProtKB/TrEMBL
    G3XAN4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    71003150..71038323 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15629.3 GenPept UniProtKB/Swiss-Prot:Q15629

Gene LinkOut

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