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Fbxl9 F-box and leucine-rich repeat protein 9 [ Mus musculus (house mouse) ]

Gene ID: 234684, updated on 2-Nov-2024

Summary

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Official Symbol
Fbxl9provided by MGI
Official Full Name
F-box and leucine-rich repeat protein 9provided by MGI
Primary source
MGI:MGI:2443262
See related
Ensembl:ENSMUSG00000041679 AllianceGenome:MGI:2443262
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBL9; Lrrc29; A630024J02Rik
Summary
Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Predicted to be part of SCF ubiquitin ligase complex. Is expressed in adrenal gland; brain; gonad; metanephros; and spleen. Orthologous to human FBXL9P (F-box and leucine rich repeat protein, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 48.5), liver E14.5 (RPKM 7.9) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxl9 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106038972..106052952, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105312340..105326320, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107822735-107822970 Neighboring gene E2F transcription factor 4 Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328 Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene transmembrane protein 208 Neighboring gene formin homology 2 domain containing 1 Neighboring gene predicted gene, 46049

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine-rich repeat-containing protein 29
Names
leucine rich repeat containing 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368408.1 → NP_001355337.1  leucine-rich repeat-containing protein 29 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124584
    Consensus CDS
    CCDS90448.1
    UniProtKB/TrEMBL
    A0A1B0GQY9
    Related
    ENSMUSP00000147309.2, ENSMUST00000210412.2
    Conserved Domains (4) summary
    cd09293
    Location:240 → 428
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:280 → 305
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3 → 38
    F-box-like
    cl39015
    Location:118 → 360
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  2. NM_001368409.1 → NP_001355338.1  leucine-rich repeat-containing protein 29 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124584
    UniProtKB/TrEMBL
    Q3UG51
    Conserved Domains (4) summary
    smart00256
    Location:5 → 38
    FBOX; A Receptor for Ubiquitination Targets
    sd00034
    Location:254 → 279
    LRR_AMN1; leucine-rich repeat [structural motif]
    cl28166
    Location:240 → 444
    AMN1; Antagonist of mitotic exit network protein 1
    cl29113
    Location:118 → 360
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. NM_177449.4 → NP_803232.2  leucine-rich repeat-containing protein 29 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124584
    Consensus CDS
    CCDS57641.1
    UniProtKB/TrEMBL
    F6SF53
    Related
    ENSMUSP00000063248.8, ENSMUST00000070508.8
    Conserved Domains (2) summary
    cd09293
    Location:57 → 131
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:26 → 70
    LRR_AMN1; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106038972..106052952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530897.3 → XP_006530960.1  leucine-rich repeat-containing protein 29 isoform X2

    Conserved Domains (2) summary
    cd09293
    Location:140 → 254
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:26 → 52
    LRR_AMN1; leucine-rich repeat [structural motif]

  2. XM_006530893.5 → XP_006530956.1  leucine-rich repeat-containing protein 29 isoform X1

    See identical proteins and their annotated locations for XP_006530956.1

    UniProtKB/TrEMBL
    A0A1B0GQY9
    Conserved Domains (4) summary
    cd09293
    Location:240 → 428
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:280 → 305
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam12937
    Location:3 → 38
    F-box-like
    cl39015
    Location:118 → 360
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

  3. XM_036153969.1 → XP_036009862.1  leucine-rich repeat-containing protein 29 isoform X2

    Conserved Domains (2) summary
    cd09293
    Location:140 → 254
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:26 → 52
    LRR_AMN1; leucine-rich repeat [structural motif]

  4. XM_030243502.1 → XP_030099362.1  leucine-rich repeat-containing protein 29 isoform X2

    Conserved Domains (2) summary
    cd09293
    Location:140 → 254
    AMN1; Antagonist of mitotic exit network protein 1
    sd00034
    Location:26 → 52
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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