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Elmo3 engulfment and cell motility 3 [ Mus musculus (house mouse) ]

Gene ID: 234683, updated on 2-Nov-2024

Summary

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Official Symbol
Elmo3provided by MGI
Official Full Name
engulfment and cell motility 3provided by MGI
Primary source
MGI:MGI:2679007
See related
Ensembl:ENSMUSG00000014791 AllianceGenome:MGI:2679007
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ced12; CED-12; 9930107J06
Summary
Predicted to enable SH3 domain binding activity. Predicted to be involved in actin filament organization and cell motility. Predicted to be located in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; nasal cavity epithelium; and skeleton. Orthologous to human ELMO3 (engulfment and cell motility 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in colon adult (RPKM 31.3), large intestine adult (RPKM 26.4) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Elmo3 in Genome Data Viewer
Location:
8 D3; 8 53.04 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106032240..106036625)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105305461..105310623)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102636360 Neighboring gene exocyst complex component 3-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107822735-107822970 Neighboring gene E2F transcription factor 4 Neighboring gene microRNA 328 Neighboring gene F-box and leucine-rich repeat protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene transmembrane protein 208 Neighboring gene formin homology 2 domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Comparative gene expression analysis of the engulfment and cell motility (ELMO) protein family in the mouse brain. Sato Y, et al. Gene Expr Patterns, 2019 Dec. PMID 31521773
  2. Biasing the conformation of ELMO2 reveals that myoblast fusion can be exploited to improve muscle regeneration. Tran V, et al. Nat Commun, 2022 Nov 18. PMID 36400788, Free PMC Article
  3. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
  4. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
  5. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0267, MGC67684

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell motility IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
engulfment and cell motility protein 3
Names
engulfment and cell motility 3, ced-12 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172760.4 → NP_766348.3  engulfment and cell motility protein 3

    See identical proteins and their annotated locations for NP_766348.3

    Status: VALIDATED

    Source sequence(s)
    AC124584
    Consensus CDS
    CCDS22598.1
    UniProtKB/Swiss-Prot
    Q6PDE4, Q8BYZ7
    UniProtKB/TrEMBL
    Q05D34
    Related
    ENSMUSP00000105000.3, ENSMUST00000109375.4
    Conserved Domains (3) summary
    pfam04727
    Location:293 → 463
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 267
    DUF3361; Domain of unknown function (DUF3361)
    cl17171
    Location:534 → 663
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    106032240..106036625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243498.2 → XP_030099358.1  engulfment and cell motility protein 3 isoform X1

    Conserved Domains (3) summary
    pfam04727
    Location:319 → 490
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 266
    DUF3361; Domain of unknown function (DUF3361)
    cl17171
    Location:561 → 690
    PH-like; Pleckstrin homology-like domain

  2. XM_030243500.2 → XP_030099360.1  engulfment and cell motility protein 3 isoform X4

    Conserved Domains (3) summary
    pfam04727
    Location:333 → 446
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:115 → 266
    DUF3361; Domain of unknown function (DUF3361)
    cl17171
    Location:517 → 646
    PH-like; Pleckstrin homology-like domain

  3. XM_030243499.2 → XP_030099359.1  engulfment and cell motility protein 3 isoform X2

    Conserved Domains (3) summary
    pfam04727
    Location:302 → 473
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:98 → 249
    DUF3361; Domain of unknown function (DUF3361)
    cl17171
    Location:544 → 673
    PH-like; Pleckstrin homology-like domain

  4. XM_006530890.5 → XP_006530953.1  engulfment and cell motility protein 3 isoform X3

    UniProtKB/TrEMBL
    A0A1D5RMK9, Q05D34
    Related
    ENSMUSP00000148820.2, ENSMUST00000212033.2
    Conserved Domains (3) summary
    pfam04727
    Location:275 → 446
    ELMO_CED12; ELMO/CED-12 family
    pfam11841
    Location:98 → 250
    DUF3361; Domain of unknown function (DUF3361)
    cl17171
    Location:517 → 646
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BYZ7.2 GenPept UniProtKB/Swiss-Prot:Q8BYZ7

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