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Klhl26 kelch-like 26 [ Mus musculus (house mouse) ]

Gene ID: 234378, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl26provided by MGI
Official Full Name
kelch-like 26provided by MGI
Primary source
MGI:MGI:2443079
See related
Ensembl:ENSMUSG00000055707 AllianceGenome:MGI:2443079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Klkl26; C630013N10Rik
Summary
Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human KLHL26 (kelch like family member 26). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 51.8), adrenal adult (RPKM 47.8) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Klhl26 in Genome Data Viewer
Location:
8 B3.3; 8 34.15 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70902868..70929660, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (70450218..70476989, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51533 Neighboring gene cartilage oligomeric matrix protein Neighboring gene CREB regulated transcription coactivator 1 Neighboring gene STARR-positive B cell enhancer ABC_E1368 Neighboring gene RIKEN cDNA 1700020G03 gene Neighboring gene transmembrane protein 59-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

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Homology

Clone Names

  • MGC38024

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
kelch-like protein 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122830.1 → NP_001116302.1  kelch-like protein 26 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 2.
    Source sequence(s)
    AK048601, AW495342, BY230115
    Consensus CDS
    CCDS52573.1
    UniProtKB/TrEMBL
    E9Q4C1
    Related
    ENSMUSP00000129607.2, ENSMUST00000166976.3
    Conserved Domains (5) summary
    smart00612
    Location:439 → 485
    Kelch; Kelch domain
    sd00038
    Location:282 → 329
    Kelch; KELCH repeat [structural motif]
    pfam00651
    Location:19 → 87
    BTB; BTB/POZ domain
    pfam01344
    Location:333 → 370
    Kelch_1; Kelch motif
    pfam07707
    Location:95 → 196
    BACK; BTB And C-terminal Kelch

  2. NM_001364258.1 → NP_001351187.1  kelch-like protein 26 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC157774, AC158553
    Consensus CDS
    CCDS90410.1
    Related
    ENSMUSP00000147349.2, ENSMUST00000209567.2
    Conserved Domains (4) summary
    PHA03098
    Location:27 → 507
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:262 → 309
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:1 → 75
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl28903
    Location:70 → 166
    BACK; BACK (BTB and C-terminal Kelch) domain

  3. NM_178771.3 → NP_848886.1  kelch-like protein 26 isoform 2

    See identical proteins and their annotated locations for NP_848886.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2).
    Source sequence(s)
    AK049946
    Consensus CDS
    CCDS40373.1
    UniProtKB/Swiss-Prot
    Q8BGY4, Q8CIG6, Q8R153
    Related
    ENSMUSP00000069077.6, ENSMUST00000066597.13
    Conserved Domains (4) summary
    PHA03098
    Location:56 → 588
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:343 → 390
    Kelch; KELCH repeat [structural motif]
    cd18255
    Location:36 → 156
    BTB_POZ_KLHL26; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26)
    cl28903
    Location:151 → 247
    BACK; BACK (BTB and C-terminal Kelch) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70902868..70929660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243486.2 → XP_030099346.1  kelch-like protein 26 isoform X2

    Conserved Domains (2) summary
    PHA03098
    Location:100 → 342
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:97 → 144
    Kelch; KELCH repeat [structural motif]

  2. XM_006509654.5 → XP_006509717.1  kelch-like protein 26 isoform X1

    See identical proteins and their annotated locations for XP_006509717.1

    UniProtKB/Swiss-Prot
    Q8BGY4
    Conserved Domains (4) summary
    PHA03098
    Location:27 → 507
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:262 → 309
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:1 → 75
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl28903
    Location:70 → 166
    BACK; BACK (BTB and C-terminal Kelch) domain

  3. XM_030243484.2 → XP_030099344.1  kelch-like protein 26 isoform X2

    Conserved Domains (2) summary
    PHA03098
    Location:100 → 342
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:97 → 144
    Kelch; KELCH repeat [structural motif]

  4. XM_030243483.2 → XP_030099343.1  kelch-like protein 26 isoform X1

    Conserved Domains (4) summary
    PHA03098
    Location:27 → 507
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:262 → 309
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:1 → 75
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    cl28903
    Location:70 → 166
    BACK; BACK (BTB and C-terminal Kelch) domain

  5. XM_030243487.1 → XP_030099347.1  kelch-like protein 26 isoform X2

    Conserved Domains (2) summary
    PHA03098
    Location:100 → 342
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:97 → 144
    Kelch; KELCH repeat [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172052.1: Suppressed sequence

    Description
    NM_172052.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGY4.1 GenPept UniProtKB/Swiss-Prot:Q8BGY4

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