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Csgalnact1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 234356, updated on 2-Nov-2024

Summary

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Official Symbol
Csgalnact1provided by MGI
Official Full Name
chondroitin sulfate N-acetylgalactosaminyltransferase 1provided by MGI
Primary source
MGI:MGI:2442354
See related
Ensembl:ENSMUSG00000036356 AllianceGenome:MGI:2442354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSGalNAcT-1; 4732435N03Rik
Summary
Enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate biosynthetic process. Acts upstream of or within chondroitin sulfate metabolic process; extracellular matrix organization; and skeletal system development. Is active in Golgi apparatus. Is expressed in several structures, including alimentary system; cartilage; limb; nervous system; and sensory organ. Orthologous to human CSGALNACT1 (chondroitin sulfate N-acetylgalactosaminyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in limb E14.5 (RPKM 2.6), frontal lobe adult (RPKM 2.2) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Csgalnact1 in Genome Data Viewer
Location:
8 B3.3; 8 33.88 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (68809433..69188270, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (68356781..68735621, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene pleckstrin and Sec7 domain containing 3 Neighboring gene predicted gene 15991 Neighboring gene STARR-seq mESC enhancer starr_21700 Neighboring gene predicted gene, 22018 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70681079-70681379 Neighboring gene STARR-seq mESC enhancer starr_21702 Neighboring gene STARR-positive B cell enhancer mm9_chr8:70772052-70772353 Neighboring gene STARR-seq mESC enhancer starr_21703 Neighboring gene STARR-seq mESC enhancer starr_21704 Neighboring gene STARR-seq mESC enhancer starr_21705 Neighboring gene STARR-seq mESC enhancer starr_21706 Neighboring gene RIKEN cDNA 1700125H03 gene Neighboring gene SH2 domain containing 4A Neighboring gene upstream binding transcription factor, RNA polymerase I-like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21708 Neighboring gene STARR-seq mESC enhancer starr_21710 Neighboring gene STARR-positive B cell enhancer mm9_chr8:71151041-71151341 Neighboring gene STARR-positive B cell enhancer ABC_E5009 Neighboring gene STARR-seq mESC enhancer starr_21711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:71317593-71317892 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene integrator complex subunit 10 Neighboring gene predicted gene, 51577

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type. Inada R, et al. Glycobiology, 2021 Apr 1. PMID 32839819
  2. Distinct effects of chondroitin sulfate on hematopoietic cells and the stromal microenvironment in bone marrow hematopoiesis. Katagiri T, et al. Exp Hematol, 2021 Apr. PMID 33582241
  3. Increased Synthesis of Chondroitin Sulfate Proteoglycan Promotes Adult Hippocampal Neurogenesis in Response to Enriched Environment. Yamada J, et al. J Neurosci, 2018 Sep 26. PMID 30126967, Free PMC Article
  4. Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis. Yoshioka N, et al. Mol Brain, 2017 Oct 5. PMID 28982363, Free PMC Article
  5. Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex. Hou X, et al. Sci Rep, 2017 Oct 3. PMID 28974755, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.
    Title: Chondroitin sulfate N-acetylgalactosyltransferase-1 knockout shows milder phenotype in experimental autoimmune encephalomyelitis than in wild type.
  2. CSGalNAcT1 plays important roles in connective tissue organization and following intramembranous ossification of the craniofacial skeleton.
    Title: Craniofacial abnormality with skeletal dysplasia in mice lacking chondroitin sulfate N-acetylgalactosaminyltransferase-1.
  3. Here, we show that initiation of ocular dominance plasticity was impaired with reduced CS, using mice lacking a key CS-synthesizing enzyme, CSGalNAcT1. Two-photon in vivo imaging showed a weaker visual response of PV-cells with reduced CS compared to wild-type mice. Plasticity onset was restored by a homeoprotein Otx2, which binds the major CS-proteoglycan aggrecan and promotes its further expression.
    Title: Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex.
  4. CSGalNAcT1 is important for plasticity, probably due to regulation of chondroitin sulfate-dependent perineuronal nets.
    Title: Abnormalities in perineuronal nets and behavior in mice lacking CSGalNAcT1, a key enzyme in chondroitin sulfate synthesis.
  5. propose that both t1 and t2 are necessary for CS synthesis and normal chondrocyte differentiation but are not sufficient for all CS synthesis in cartilage
    Title: Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2.
  6. CSGalNAcT-1 is necessary for normal levels of endochondral ossification, and the decrease in CS amount in the growth plate by its absence causes a rapid catabolism of aggrecan.
    Title: Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is necessary for normal endochondral ossification and aggrecan metabolism.
  7. Results suggest that CSGalNAcT1 is required for normal CS production in developing cartilage.
    Title: Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucuronosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidoglycan glycosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidoglycan glycosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in UDP-N-acetylgalactosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP-N-acetylgalactosamine metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in UDP-glucuronate metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP-glucuronate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cartilage development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chondroitin sulfate biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chondroitin sulfate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in chondroitin sulfate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within chondroitin sulfate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within endochondral ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
chondroitin sulfate N-acetylgalactosaminyltransferase 1
Names
beta1,4 N-acetylgalactosaminyltransferase
beta4GalNAcT-1
chondroitin beta-1,4-N-acetylgalactosaminyltransferase 1
NP_001239552.1
NP_001351185.1
NP_766341.4
XP_006509689.1
XP_006509690.1
XP_006509691.1
XP_006509692.1
XP_006509693.1
XP_011240592.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252623.1 → NP_001239552.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_001239552.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117740, AC123813, AC124427, AC129206, BY289912
    Consensus CDS
    CCDS22341.1
    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Related
    ENSMUSP00000119817.2, ENSMUST00000130214.8
    Conserved Domains (1) summary
    cl11394
    Location:144 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. NM_001364256.1 → NP_001351185.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AC117740, AK049770, AK133567
    Consensus CDS
    CCDS22341.1
    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  3. NM_172753.5 → NP_766341.4  chondroitin sulfate N-acetylgalactosaminyltransferase 1

    See identical proteins and their annotated locations for NP_766341.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC117740, AK080687, BY289912
    Consensus CDS
    CCDS22341.1
    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Related
    ENSMUSP00000077459.7, ENSMUST00000078350.13
    Conserved Domains (1) summary
    cl11394
    Location:144 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    68809433..69188270 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509628.5 → XP_006509691.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509691.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  2. XM_006509627.5 → XP_006509690.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509690.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  3. XM_011242290.4 → XP_011240592.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011240592.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  4. XM_006509626.3 → XP_006509689.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509689.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  5. XM_006509629.2 → XP_006509692.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509692.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

  6. XM_006509630.5 → XP_006509693.1  chondroitin sulfate N-acetylgalactosaminyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_006509693.1

    UniProtKB/Swiss-Prot
    Q3UNQ5, Q3UZX6, Q5FWX8, Q8BJQ9, Q8BWV9, Q8BZU7, Q8C195, Q8R0M6
    Conserved Domains (1) summary
    cl11394
    Location:144 → 505
    Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

RNA

  1. XR_004934803.1 RNA Sequence

  2. XR_004934802.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BJQ9.1 GenPept UniProtKB/Swiss-Prot:Q8BJQ9

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