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Zfp958 zinc finger protein 958 [ Mus musculus (house mouse) ]

Gene ID: 233987, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp958provided by MGI
Official Full Name
zinc finger protein 958provided by MGI
Primary source
MGI:MGI:2385298
See related
Ensembl:ENSMUSG00000058748 AllianceGenome:MGI:2385298
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be active in nucleoplasm. Is expressed in heart; limb; and limb mesenchyme. Orthologous to several human genes including ZNF117 (zinc finger protein 117); ZNF490 (zinc finger protein 490); and ZNF708 (zinc finger protein 708). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E18 (RPKM 1.7), bladder adult (RPKM 1.5) and 24 other tissues See more
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Genomic context

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See Zfp958 in Genome Data Viewer
Location:
8 A1.1; 8 2.07 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (4663170..4682572)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (4613170..4632572)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene ceramide synthase 4 Neighboring gene STARR-seq mESC enhancer starr_20617 Neighboring gene vomeronasal 2, receptor, pseudogene 89 Neighboring gene STARR-seq mESC enhancer starr_20618 Neighboring gene STARR-seq mESC enhancer starr_20619 Neighboring gene STARR-seq mESC enhancer starr_20620 Neighboring gene serine/threonine kinase 38 like pseudogene Neighboring gene predicted gene, 30502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 878

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368404.1 → NP_001355333.1  zinc finger protein 878 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC155814
    Conserved Domains (3) summary
    COG5048
    Location:125 → 484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:211 → 231
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:26 → 66
    KRAB; KRAB box

  2. NM_001368405.1 → NP_001355334.1  zinc finger protein 878 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC155814
    Related
    ENSMUSP00000072937.6, ENSMUST00000073201.6
    Conserved Domains (2) summary
    COG5048
    Location:71 → 430
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:157 → 177
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_145591.5 → NP_663566.1  zinc finger protein 878 isoform 2

    See identical proteins and their annotated locations for NP_663566.1

    Status: VALIDATED

    Source sequence(s)
    AC155814
    Consensus CDS
    CCDS80856.1
    UniProtKB/TrEMBL
    Q99LG7
    Related
    ENSMUSP00000143842.2, ENSMUST00000202692.5
    Conserved Domains (5) summary
    smart00349
    Location:4 → 45
    KRAB; krueppel associated box
    COG5048
    Location:103 → 462
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:189 → 209
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:4 → 43
    KRAB; KRAB box
    pfam13465
    Location:257 → 281
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    4663170..4682572
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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