U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

NUDCD3 NudC domain containing 3 [ Homo sapiens (human) ]

Gene ID: 23386, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
NUDCD3provided by HGNC
Official Full Name
NudC domain containing 3provided by HGNC
Primary source
HGNC:HGNC:22208
See related
Ensembl:ENSG00000015676 MIM:610296; AllianceGenome:HGNC:22208
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NudCL
Summary
The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 28.0), ovary (RPKM 14.4) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
7p13
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (44379119..44490658, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (44538885..44650393, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (44418718..44530257, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44253740-44254655 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44257065-44257612 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44257613-44258158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44260592-44261156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44261157-44261720 Neighboring gene YKT6 v-SNARE homolog Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44275325-44276208 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25935 Neighboring gene calcium/calmodulin dependent protein kinase II beta Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44289329-44289847 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44301759-44302258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44302657-44303488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44303489-44304320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44307207-44307708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44307709-44308208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44311666-44312166 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44322903-44323685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44328206-44328848 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44329545-44330046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44333819-44334319 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44348485-44349088 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:44349089-44349690 Neighboring gene uncharacterized LOC124901621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25939 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:44389311-44389811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25940 Neighboring gene Sharpr-MPRA regulatory region 3634 Neighboring gene ribosomal protein L32 pseudogene 18 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18144 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:44532074-44532200 Neighboring gene RNA, U6 small nuclear 1097, pseudogene Neighboring gene ribosomal protein L36a pseudogene 27

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody. Cai Y, et al. Cell Res, 2009 Nov. PMID 19806165
  2. A mammalian NudC-like protein essential for dynein stability and cell viability. Zhou T, et al. Proc Natl Acad Sci U S A, 2006 Jun 13. PMID 16754861, Free PMC Article
  3. Subunit composition of the human cytoplasmic dynein-2 complex. Asante D, et al. J Cell Sci, 2014 Nov 1. PMID 25205765, Free PMC Article
  4. USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling. Luo K, et al. EMBO J, 2017 May 15. PMID 28363942, Free PMC Article
  5. Disease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation. Chen Z, et al. Cell Death Differ, 2022 Oct. PMID 35379950, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. overexpression of NudCL inhibits cytokinesis
    Title: Inhibition of cytokinesis by overexpression of NudCL that is localized to the centrosome and midbody.
  3. Data characterize a previously undescribed mammalian NudC-like protein (NudCL), which appears to influence the stabilization of dynein intermediate chain
    Title: A mammalian NudC-like protein essential for dynein stability and cell viability.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA1068

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to pericentriolar material IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytoplasmic dynein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
nudC domain-containing protein 3
Names
NudC-like protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015332.4 → NP_056147.2  nudC domain-containing protein 3

    See identical proteins and their annotated locations for NP_056147.2

    Status: REVIEWED

    Source sequence(s)
    AB028991, AC004453, AW138459, CN386226
    Consensus CDS
    CCDS5490.2
    UniProtKB/Swiss-Prot
    Q8IVD9, Q9BTI3, Q9H7W9, Q9UPT4
    UniProtKB/TrEMBL
    B0FTY2
    Related
    ENSP00000347626.6, ENST00000355451.8
    Conserved Domains (2) summary
    cd06495
    Location:184 → 285
    p23_NUDCD3_like; p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.
    pfam14050
    Location:9 → 67
    Nudc_N; N-terminal conserved domain of Nudc

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    44379119..44490658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515247.3 → XP_011513549.1  nudC domain-containing protein 3 isoform X1

    UniProtKB/TrEMBL
    B0FTY2
    Conserved Domains (2) summary
    cd06495
    Location:184 → 285
    p23_NUDCD3_like; p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.
    pfam14050
    Location:9 → 67
    Nudc_N; N-terminal conserved domain of Nudc

  2. XM_017011908.2 → XP_016867397.1  nudC domain-containing protein 3 isoform X2

RNA

  1. XR_007059994.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    44538885..44650393 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357712.1 → XP_054213687.1  nudC domain-containing protein 3 isoform X1

  2. XM_054357713.1 → XP_054213688.1  nudC domain-containing protein 3 isoform X2

RNA

  1. XR_008487548.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IVD9.3 GenPept UniProtKB/Swiss-Prot:Q8IVD9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous