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UFL1 - UFM1 specific ligase 1

Enables UFM1 ligase activity and protein kinase binding activity. Involved in several processes, including protein K69-linked ufmylation; regulation of intracellular signal transduction; and regulation of protein metabolic process. Acts upstream of or within several processes, including positive regulation of cell population proliferation; regulation of proteasomal ubiquitin-dependent protein catabolic process; and response to endoplasmic reticulum stress. Located in cytoplasm; nucleus; and site of double-strand break. Part of protein-containing complex. Is active in endoplasmic reticulum membrane and mitochondrial outer membrane. [provided by Alliance of Genome Resources, Oct 2024]

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Species Gene Architecture aa