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MATCAP2 microtubule associated tyrosine carboxypeptidase 2 [ Homo sapiens (human) ]

Gene ID: 23366, updated on 2-Nov-2024

Summary

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Official Symbol
MATCAP2provided by HGNC
Official Full Name
microtubule associated tyrosine carboxypeptidase 2provided by HGNC
Primary source
HGNC:HGNC:22206
See related
Ensembl:ENSG00000164542 MIM:619896; AllianceGenome:HGNC:22206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMCP2; KIAA0895
Summary
Predicted to enable carboxypeptidase activity; metal ion binding activity; and metallopeptidase activity. Predicted to be involved in proteolysis. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis (RPKM 10.8), kidney (RPKM 3.9) and 18 other tissues See more
Orthologs
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Genomic context

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See MATCAP2 in Genome Data Viewer
Location:
7p14.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (36324152..36390357, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (36465400..36531625, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (36363761..36429966, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18100 Neighboring gene NANOG hESC enhancer GRCh37_chr7:36197697-36198217 Neighboring gene MARK2 pseudogene 7 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36254183-36255020 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36255021-36255856 Neighboring gene endonuclease/exonuclease/phosphatase family domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:36285803-36286305 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36297422-36298230 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36298231-36299037 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36320693-36321354 Neighboring gene Sharpr-MPRA regulatory region 9097 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36351141-36351658 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:36399716-36400433 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18101 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:36429116-36429706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:36429707-36430297 Neighboring gene anillin, actin binding protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr7:36544967-36546166 Neighboring gene NFE2L2 motif-containing MPRA enhancer 148 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_98398 Neighboring gene acyloxyacyl hydrolase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:36655105-36655606 Neighboring gene AOAH intronic transcript 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:36693505-36694049 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:36701053-36701595 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:36802118-36803317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25844 Neighboring gene nucleophosmin 1 pseudogene 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A family of carboxypeptidases catalyzing α- and β-tubulin tail processing and deglutamylation. Nicot S, et al. Sci Adv, 2023 Sep 15. PMID 37703372, Free PMC Article
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1998 Dec 31. PMID 10048485
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative tyrosine carboxypeptidase MATCAP2
Names
tubulin metallocarboxypeptidase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100425.2 → NP_001093895.1  putative tyrosine carboxypeptidase MATCAP2 isoform 1

    See identical proteins and their annotated locations for NP_001093895.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC006960, BC028678, BC056191, BE463421, DB462178
    Consensus CDS
    CCDS43570.1
    UniProtKB/Swiss-Prot
    B4DF35, B7ZLT4, B9EGB9, O94969, Q0VGC1, Q7Z4L2, Q8NCT3
    UniProtKB/TrEMBL
    B4DYR3
    Related
    ENSP00000297063.6, ENST00000297063.10
    Conserved Domains (1) summary
    cl06858
    Location:292 → 507
    DUF1704; Domain of unknown function (DUF1704)

  2. NM_001199706.2 → NP_001186635.1  putative tyrosine carboxypeptidase MATCAP2 isoform 3

    See identical proteins and their annotated locations for NP_001186635.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two exons from the 5' end and contains an alternate 5' exon and an additional in-frame exon, as compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and an additional internal segment, as compared to isoform 1.
    Source sequence(s)
    AC006960, BC144032, BE463421, DC403204
    Consensus CDS
    CCDS56484.1
    UniProtKB/TrEMBL
    B4DYR3
    Related
    ENSP00000390837.1, ENST00000440378.6
    Conserved Domains (1) summary
    cl06858
    Location:202 → 504
    DUF1704; Domain of unknown function (DUF1704)

  3. NM_001199707.2 → NP_001186636.1  putative tyrosine carboxypeptidase MATCAP2 isoform 4

    See identical proteins and their annotated locations for NP_001186636.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two exons from the 5' end and contains an alternate 5' exon, as compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC006960, BC056191, BC110422, BE463421
    Consensus CDS
    CCDS56483.1
    UniProtKB/TrEMBL
    B4DYR3
    Related
    ENSP00000344805.5, ENST00000338533.9
    Conserved Domains (1) summary
    cl06858
    Location:279 → 494
    DUF1704; Domain of unknown function (DUF1704)

  4. NM_001199708.2 → NP_001186637.1  putative tyrosine carboxypeptidase MATCAP2 isoform 5

    See identical proteins and their annotated locations for NP_001186637.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two exons from the 5' end and contains an alternate 5' exon, which results in a downstream AUG start codon, and has an additional in-frame exon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus and an additional internal segment, as compared to isoform 1.
    Source sequence(s)
    AC006960, AK293912, AK302632, BE463421, DC403070
    Consensus CDS
    CCDS56482.1
    UniProtKB/TrEMBL
    B4DYR3
    Related
    ENSP00000389985.1, ENST00000436884.5
    Conserved Domains (1) summary
    cl06858
    Location:102 → 404
    DUF1704; Domain of unknown function (DUF1704)

  5. NM_001300956.2 → NP_001287885.1  putative tyrosine carboxypeptidase MATCAP2 isoform 6

    See identical proteins and their annotated locations for NP_001287885.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in its 5' UTR and 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (6) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC006960, BU507941, DC403070
    Consensus CDS
    CCDS75583.1
    UniProtKB/TrEMBL
    B4DYW2, E9PE22
    Related
    ENSP00000390183.1, ENST00000453212.5
    Conserved Domains (1) summary
    cl06858
    Location:43 → 262
    DUF1704; Domain of unknown function (DUF1704)

  6. NM_015314.3 → NP_056129.2  putative tyrosine carboxypeptidase MATCAP2 isoform 2

    See identical proteins and their annotated locations for NP_056129.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two exons from the 5' end and contains an alternate 5' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, as compared to isoform 1.
    Source sequence(s)
    AB020702, AC006960, BC056191, BE463421, DB060820
    Consensus CDS
    CCDS47573.1
    UniProtKB/TrEMBL
    B4DYR3
    Related
    ENSP00000319251.6, ENST00000317020.10
    Conserved Domains (1) summary
    cl06858
    Location:241 → 456
    DUF1704; Domain of unknown function (DUF1704)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    36324152..36390357 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446701.2 → XP_024302469.1  putative tyrosine carboxypeptidase MATCAP2 isoform X2

    UniProtKB/TrEMBL
    B4DYR3
    Conserved Domains (1) summary
    cl06858
    Location:102 → 404
    DUF1704; Domain of unknown function (DUF1704)

  2. XM_024446702.2 → XP_024302470.1  putative tyrosine carboxypeptidase MATCAP2 isoform X3

    Conserved Domains (1) summary
    cl06858
    Location:141 → 356
    DUF1704; Domain of unknown function (DUF1704)

  3. XM_005249690.5 → XP_005249747.1  putative tyrosine carboxypeptidase MATCAP2 isoform X4

    See identical proteins and their annotated locations for XP_005249747.1

    UniProtKB/TrEMBL
    B4DYW2, E9PE22
    Conserved Domains (1) summary
    cl06858
    Location:43 → 262
    DUF1704; Domain of unknown function (DUF1704)

  4. XM_005249689.4 → XP_005249746.1  putative tyrosine carboxypeptidase MATCAP2 isoform X1

    UniProtKB/TrEMBL
    B4DYR3
    Conserved Domains (1) summary
    cl06858
    Location:240 → 542
    DUF1704; Domain of unknown function (DUF1704)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    36465400..36531625 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357702.1 → XP_054213677.1  putative tyrosine carboxypeptidase MATCAP2 isoform X2

  2. XM_054357703.1 → XP_054213678.1  putative tyrosine carboxypeptidase MATCAP2 isoform X3

  3. XM_054357704.1 → XP_054213679.1  putative tyrosine carboxypeptidase MATCAP2 isoform X4

    UniProtKB/TrEMBL
    E9PE22

  4. XM_054357701.1 → XP_054213676.1  putative tyrosine carboxypeptidase MATCAP2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NCT3.4 GenPept UniProtKB/Swiss-Prot:Q8NCT3

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