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USP24 ubiquitin specific peptidase 24 [ Homo sapiens (human) ]

Gene ID: 23358, updated on 3-Apr-2024

Summary

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Official Symbol
USP24provided by HGNC
Official Full Name
ubiquitin specific peptidase 24provided by HGNC
Primary source
HGNC:HGNC:12623
See related
Ensembl:ENSG00000162402 MIM:610569; AllianceGenome:HGNC:12623
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP24 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 9.9), lymph node (RPKM 9.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1p32.3
Exon count:
71
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (55066359..55215364, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54947243..55096207, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55532032..55681037, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55466287-55466787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55484247-55484747 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55488329-55488955 Neighboring gene barttin CLCNK type accessory subunit beta Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55493259-55493762 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:55493763-55494266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55494267-55494770 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:55501658-55501847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55509121-55509622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55509623-55510122 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55514655-55515210 Neighboring gene proprotein convertase subtilisin/kexin type 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1071 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 928 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 929 Neighboring gene uncharacterized LOC100507634 Neighboring gene MIR4422 host gene Neighboring gene glycogenin 1 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy. Wang YC, et al. Oncogene, 2016 Jul 14. PMID 26568301
  2. Transcriptional regulation of human USP24 gene expression by NF-kappa B. Wang K, et al. J Neurochem, 2014 Mar. PMID 24286619
  3. Ubiquitin-specific protease 24 promotes EV71 infection by restricting K63-linked polyubiquitination of TBK1. Zang L, et al. Virol Sin, 2023 Feb. PMID 36334706, Free PMC Article
  4. USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma. Bedekovics T, et al. Cancer Res, 2021 Mar 1. PMID 33355202
  5. USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy. Wang YC, et al. Nat Commun, 2018 Sep 28. PMID 30266897, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24.
    Title: MiR-21-5p promotes sorafenib resistance and hepatocellular carcinoma progression by regulating SIRT7 ubiquitination through USP24.
  2. USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway.
    Title: USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway.
  3. USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
    Title: USP24 Is a Cancer-Associated Ubiquitin Hydrolase, Novel Tumor Suppressor, and Chromosome Instability Gene Deleted in Neuroblastoma.
  4. USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.
    Title: USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy.
  5. The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
    Title: The PARK10 gene USP24 is a negative regulator of autophagy and ULK1 protein stability.
  6. Data indicate that ubiquitin specific peptidase 24 (USP24) promotes Interleukin-6 (IL-6) expression, which might be beneficial for cancer therapy.
    Title: USP24 induces IL-6 in tumor-associated microenvironment by stabilizing p300 and β-TrCP and promotes cancer malignancy.
  7. USP24 level was decreased during the early stage of cancer and the mitotic stage of the cell cycle to regulate its substrates p300, Bax, E2F4 and securin, resulting in decreased cell apoptosis and increased cell cycle progression and, thus, cancer formation.
    Title: EGF-mediated inhibition of ubiquitin-specific peptidase 24 expression has a crucial role in tumorigenesis.
  8. Data show that ubiquitin-specific peptidase 24 (USP24) is highly expressed in cell lines with enhanced malignancy and in late-stage lung cancer clinical samples.
    Title: Variants of ubiquitin-specific peptidase 24 play a crucial role in lung cancer malignancy.
  9. USP24 deubiquitinase regulates the DNA damage response by directly targeting the p53 tumor suppressor.
    Title: The deubiquitinating enzyme USP24 is a regulator of the UV damage response.
  10. the novel compound EOAI3402143 dose-dependently inhibited Usp9x and Usp24 activity, increased tumor cell apoptosis, and fully blocked or regressed myeloma tumors in mice.
    Title: Targeting deubiquitinase activity with a novel small-molecule inhibitor as therapy for B-cell malignancies.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
EBI GWAS Catalog
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31309, KIAA1057

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type deubiquitinase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 24
Names
deubiquitinating enzyme 24
ubiquitin specific protease 24
ubiquitin thioesterase 24
ubiquitin thiolesterase 24
ubiquitin-specific processing protease 24
NP_056121.2
XP_005270747.1
XP_016856320.1
XP_016856321.1
XP_016856325.1
XP_016856326.1
XP_047272480.1
XP_047272481.1
XP_047272482.1
XP_047272483.1
XP_054191582.1
XP_054191583.1
XP_054191584.1
XP_054191585.1
XP_054191586.1
XP_054191587.1
XP_054191588.1
XP_054191589.1
XP_054191590.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015306.3 → NP_056121.2  ubiquitin carboxyl-terminal hydrolase 24

    See identical proteins and their annotated locations for NP_056121.2

    Status: VALIDATED

    Source sequence(s)
    AC091609
    Consensus CDS
    CCDS44154.2
    UniProtKB/Swiss-Prot
    Q6ZSY2, Q8N2Y4, Q9NXD1, Q9UPU5
    UniProtKB/TrEMBL
    A0A0U1RQI9
    Related
    ENSP00000294383.5, ENST00000294383.7
    Conserved Domains (3) summary
    cd02659
    Location:1687 → 2044
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cd14286
    Location:6 → 42
    UBA_UBP24; UBA domain found in ubiquitin carboxyl-terminal hydrolase 24 (UBP24) and similar proteins
    pfam00443
    Location:1689 → 2039
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    55066359..55215364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047416524.1 → XP_047272480.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X3

  2. XM_017000832.2 → XP_016856321.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X2

    UniProtKB/TrEMBL
    A0A0U1RQI9

  3. XM_017000831.2 → XP_016856320.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X1

    UniProtKB/TrEMBL
    A0A0U1RQI9

  4. XM_005270690.4 → XP_005270747.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X4

    Conserved Domains (2) summary
    cd02659
    Location:1092 → 1449
    peptidase_C19C; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    pfam00443
    Location:1094 → 1444
    UCH; Ubiquitin carboxyl-terminal hydrolase

  5. XM_047416525.1 → XP_047272481.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X5

  6. XM_047416526.1 → XP_047272482.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X6

  7. XM_017000836.2 → XP_016856325.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X7

  8. XM_047416527.1 → XP_047272483.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X8

  9. XM_017000837.2 → XP_016856326.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X9

RNA

  1. XR_001737080.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    54947243..55096207 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054335609.1 → XP_054191584.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X3

  2. XM_054335608.1 → XP_054191583.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X2

  3. XM_054335607.1 → XP_054191582.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X1

  4. XM_054335610.1 → XP_054191585.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X4

  5. XM_054335611.1 → XP_054191586.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X5

  6. XM_054335612.1 → XP_054191587.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X6

  7. XM_054335613.1 → XP_054191588.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X7

  8. XM_054335614.1 → XP_054191589.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X8

  9. XM_054335615.1 → XP_054191590.1  ubiquitin carboxyl-terminal hydrolase 24 isoform X9

RNA

  1. XR_008485967.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UPU5.3 GenPept UniProtKB/Swiss-Prot:Q9UPU5

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