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Siglech sialic acid binding Ig-like lectin H [ Mus musculus (house mouse) ]

Gene ID: 233274, updated on 2-Nov-2024

Summary

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Official Symbol
Siglechprovided by MGI
Official Full Name
sialic acid binding Ig-like lectin Hprovided by MGI
Primary source
MGI:MGI:2443256
See related
Ensembl:ENSMUSG00000051504 AllianceGenome:MGI:2443256
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Siglec-H; 6430529G09Rik
Summary
Enables cargo receptor activity. Acts upstream of or within establishment of localization in cell and receptor-mediated endocytosis. Located in cell surface. Is expressed in liver. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 7.9), mammary gland adult (RPKM 5.0) and 11 other tissues See more
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Genomic context

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See Siglech in Genome Data Viewer
Location:
7 B5; 7 33.42 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (55417916..55429196)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (55768154..55779448)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18951 Neighboring gene ribosomal protein S7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18952 Neighboring gene STARR-seq mESC enhancer starr_18954 Neighboring gene STARR-seq mESC enhancer starr_18955 Neighboring gene predicted gene, 26482 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:63049366-63049475 Neighboring gene tubulin, gamma complex component 5 Neighboring gene STARR-seq mESC enhancer starr_18956 Neighboring gene STARR-positive B cell enhancer mm9_chr7:63113113-63113414 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene STARR-seq mESC enhancer starr_18959 Neighboring gene peroxiredoxin 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Siglec-H(-/-) Plasmacytoid Dendritic Cells Protect Against Acute Liver Injury by Suppressing IFN-γ/Th1 Response and Promoting IL-21(+) CD4 T Cells. Ahodantin J, et al. Cell Mol Gastroenterol Hepatol, 2024. PMID 38849082, Free PMC Article
  2. Siglec-H is an IPC-specific receptor that modulates type I IFN secretion through DAP12. Blasius AL, et al. Blood, 2006 Mar 15. PMID 16293595, Free PMC Article
  3. Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors. Zhang J, et al. Blood, 2006 May 1. PMID 16397130
  4. Siglec-H-Deficient Mice Show Enhanced Type I IFN Responses, but Do Not Develop Autoimmunity After Influenza or LCMV Infections. Szumilas N, et al. Front Immunol, 2021. PMID 34497606, Free PMC Article
  5. Sampling and signaling in plasmacytoid dendritic cells: the potential roles of Siglec-H. Blasius AL, et al. Trends Immunol, 2006 Jun. PMID 16679063

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Siglec-H[-/-] Plasmacytoid Dendritic Cells Protect Against Acute Liver Injury by Suppressing IFN-gamma/Th1 Response and Promoting IL-21[+] CD4 T Cells.
    Title: Siglec-H(-/-) Plasmacytoid Dendritic Cells Protect Against Acute Liver Injury by Suppressing IFN-γ/Th1 Response and Promoting IL-21(+) CD4 T Cells.
  2. Synthesized branched sialylated glycan clusters interacted with sialic acid-binding immunoglobulin-like lectin H (Siglec-H), which is known to be a microglia-specific molecule.
    Title: Branched Sialylated N-glycans Are Accumulated in Brain Synaptosomes and Interact with Siglec-H.
  3. The Siglec-H is specifically expressed by microglia in the steady state developing CNS and adult mice, except for in the choroid plexus
    Title: Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes.
  4. These results show that Siglec-H normally serves as a modulator of type I IFN responses after infection with a persistent virus and thereby prevents induction of autoimmune disease
    Title: Siglec-H protects from virus-triggered severe systemic autoimmunity.
  5. We found that lack of SiglecH enhanced IFN-I responses to viral infection, regardless of whether Plasmacytoid dendritic cells were depleted
    Title: Cell depletion in mice that express diphtheria toxin receptor under the control of SiglecH encompasses more than plasmacytoid dendritic cells.
  6. Siglec-H deficiency induced a significant increase in serum IFNalpha levels following systemic MCMV infection. Although Siglec-H modulates anti-viral IFNalpha production, the control of viral replication was unchanged in vivo.
    Title: Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance.
  7. Antigen delivery to plasmacytoid dendritic cells via the specifically expressed surface molecule Siglec-H inhibits T helper (Th) cell and antibody responses in the presence of strong immune stimulation in an antigen-specific manner.
    Title: Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity.
  8. are a family of sialic acid receptor proteins expressed in immune cells, recognize their ligands and play a role in the signal transduction.
    Title: [Functions and molecular evolution of Siglecs, a family of sialic acid receptor proteins].
  9. Siglec-H was expressed specifically on plasmacytoid dendritic cell precursors in bone marrow, spleen, blood, and lymph nodes.
    Title: Characterization of Siglec-H as a novel endocytic receptor expressed on murine plasmacytoid dendritic cell precursors.
  10. A member of the sialic acid binding Ig-like lectin (Siglec) family, Siglec-H, has recently been identified as a specific surface marker for pDCs in mice.
    Title: Sampling and signaling in plasmacytoid dendritic cells: the potential roles of Siglec-H.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC106898

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cargo receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables sialic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within establishment of localization in cell IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sialic acid binding Ig-like lectin H
Names
SIGLEC-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310738.2 → NP_001297667.1  sialic acid binding Ig-like lectin H isoform 2 precursor

    See identical proteins and their annotated locations for NP_001297667.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AC160534
    Consensus CDS
    CCDS80731.1
    UniProtKB/TrEMBL
    A0A4W8, G3X9N0
    Related
    ENSMUSP00000091920.7, ENSMUST00000094360.13
    Conserved Domains (2) summary
    pfam07679
    Location:32 → 144
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  2. NM_001310740.2 → NP_001297669.1  sialic acid binding Ig-like lectin H isoform 3 precursor

    See identical proteins and their annotated locations for NP_001297669.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1.
    Source sequence(s)
    AC160534
    Consensus CDS
    CCDS80732.1
    UniProtKB/TrEMBL
    B7ZMQ5
    Related
    ENSMUSP00000134721.2, ENSMUST00000173835.2
    Conserved Domains (1) summary
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  3. NM_001401813.1 → NP_001388742.1  sialic acid binding Ig-like lectin H isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC160534

  4. NM_178706.6 → NP_848821.2  sialic acid binding Ig-like lectin H isoform 1 precursor

    See identical proteins and their annotated locations for NP_848821.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC160534
    Consensus CDS
    CCDS21313.2
    UniProtKB/TrEMBL
    Q3Y597, Q4QQK7
    Related
    ENSMUSP00000058875.9, ENSMUST00000060416.15
    Conserved Domains (2) summary
    cd00096
    Location:40 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    55417916..55429196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152979.1 → XP_036008872.1  sialic acid binding Ig-like lectin H isoform X9

    Conserved Domains (2) summary
    cd00096
    Location:40 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  2. XM_036152978.1 → XP_036008871.1  sialic acid binding Ig-like lectin H isoform X8

    Conserved Domains (2) summary
    cd00096
    Location:40 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  3. XM_036152977.1 → XP_036008870.1  sialic acid binding Ig-like lectin H isoform X7

    Conserved Domains (2) summary
    cd00096
    Location:87 → 91
    Ig; Ig strand A [structural motif]
    cl11960
    Location:87 → 172
    Ig; Immunoglobulin domain

  4. XM_036152974.1 → XP_036008867.1  sialic acid binding Ig-like lectin H isoform X4

    Conserved Domains (2) summary
    cd00096
    Location:40 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  5. XM_036152973.1 → XP_036008866.1  sialic acid binding Ig-like lectin H isoform X1

    Conserved Domains (2) summary
    cd00096
    Location:40 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  6. XM_011250857.4 → XP_011249159.1  sialic acid binding Ig-like lectin H isoform X2

    Conserved Domains (1) summary
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  7. XM_006540827.5 → XP_006540890.2  sialic acid binding Ig-like lectin H isoform X5

    UniProtKB/TrEMBL
    Q3Y597
    Conserved Domains (1) summary
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  8. XM_011250858.4 → XP_011249160.1  sialic acid binding Ig-like lectin H isoform X3

    UniProtKB/TrEMBL
    Q3Y597
    Conserved Domains (1) summary
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  9. XM_011250859.3 → XP_011249161.1  sialic acid binding Ig-like lectin H isoform X6

    See identical proteins and their annotated locations for XP_011249161.1

    UniProtKB/TrEMBL
    Q3Y597, Q4QQK7
    Conserved Domains (2) summary
    cd00096
    Location:40 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  10. XM_036152975.1 → XP_036008868.1  sialic acid binding Ig-like lectin H isoform X6

    UniProtKB/TrEMBL
    Q3Y597, Q4QQK7
    Related
    ENSMUSP00000130632.3, ENSMUST00000165045.9
    Conserved Domains (2) summary
    cd00096
    Location:40 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  11. XM_036152976.1 → XP_036008869.1  sialic acid binding Ig-like lectin H isoform X6

    UniProtKB/TrEMBL
    Q3Y597, Q4QQK7
    Related
    ENSMUSP00000130943.2, ENSMUST00000171077.8
    Conserved Domains (2) summary
    cd00096
    Location:40 → 44
    Ig; Ig strand A' [structural motif]
    cl11960
    Location:40 → 145
    Ig; Immunoglobulin domain

  12. XM_036152980.1 → XP_036008873.1  sialic acid binding Ig-like lectin H isoform X11

    Conserved Domains (2) summary
    cd00096
    Location:15 → 20
    Ig; Ig strand C [structural motif]
    cl11960
    Location:2 → 69
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
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