NEDD4L NEDD4 like E3 ubiquitin protein ligase [Homo sapiens (human)] - Gene

Summary

Official Symbol: NEDD4Lprovided by HGNC
Official Full Name: NEDD4 like E3 ubiquitin protein ligaseprovided by HGNC
Primary source: HGNC:HGNC:7728
See related: Ensembl:ENSG00000049759 MIM:606384; AllianceGenome:HGNC:7728
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RSP5; PVNH7; NEDD4-2; NEDD4.2; hNEDD4-2
Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Expression: Broad expression in prostate (RPKM 13.1), kidney (RPKM 13.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 18q21.31

Exon count:: 43

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	18	NC_000018.10 (58044226..58401540)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	18	NC_060942.1 (58244126..58602300)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	18	NC_000018.9 (55711458..56068772)

Chromosome 18 - NC_000018.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NEDD4L intramolecular interactions regulate its auto and substrate NaV1.5 ubiquitination.
Title: NEDD4L intramolecular interactions regulate its auto and substrate Na(V)1.5 ubiquitination.
NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells.
Title: NEDD4L is a promoter for angiogenesis and cell proliferation in human umbilical vein endothelial cells.
METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.
Title: METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke.
Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations.
Title: Investigation of the Binding Interaction of Mfsd2a with NEDD4-2 via Molecular Dynamics Simulations.
Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.
Title: Physiological Functions of the Ubiquitin Ligases Nedd4-1 and Nedd4-2.
Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
Title: Bacterial DNA promoting inflammation via the Sgk1/Nedd4L/Syk pathway in mast cells contributes to antihistamine-nonresponsive CSU.
The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.
Title: The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.
Genetic analysis of periventricular nodular heterotopia 7 caused by a novel NEDD4L missense mutation: Case and literature summary.
Title: Genetic analysis of periventricular nodular heterotopia 7 caused by a novel NEDD4L missense mutation: Case and literature summary.
Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia.
Title: Expression of NEDD4L and ENaC in Urinary Extracellular Vesicles in Pre-eclampsia.
NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.
Title: NEDD4L inhibits migration, invasion, cisplatin resistance and promotes apoptosis of bladder cancer cells by inactivating the p62/Keap1/Nrf2 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (144)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Periventricular nodular heterotopia 7 MedGen: C4310669 OMIM: 617201 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13). EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide meta-analysis identifies new susceptibility loci for migraine. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 replication is enhanced by CIT expression, which is dependent on NEDD4L expression as shown through siRNA knockdown of NEDD4L	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Angiomotin (AMOT) stimulates NEDD4L-dependent release of HIV-1 Gag delta PTAP/YP in a does-dependent manner in 293T cells	PubMed
	gag	Angiomotin (AMOT), AMOT-like protein 1, and AMOT-like protein 2 bind directly and specifically to NEDD4L and HIV-1 Gag-delta p6 in protein pull-down experiments	PubMed
	gag	The residual C2 domain (residues 1-31) of NEDD4-2s confers the ability to associate with HIV-1 Gag and to rescue HIV-1delta(PTAPP) budding	PubMed
	gag	Targeting of the catalytic HECT domain (residues 598-952) of NEDD4-2s to HIV-1 Gag via CypA is sufficient to rescue HIV-1 budding defects	PubMed
Vpr	vpr	HIV-1 Vpr is identified to have a physical interaction with neural precursor cell expressed, developmentally down-regulated 4-like (NEDD4L) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses	PubMed
nucleocapsid	gag	Mutations in the basic residues of the nucleocapsid domain of Gag cause severe defects in HIV-1 release, and overexpression of Nedd4.2 rescues NC mutant release defects	PubMed
p6	gag	The residual C2-domain (amino acids 1-31) in NEDD4L is essential for the rescue of p6 late-domain mutants	PubMed
	gag	NEDD4L-mediated stimulation of virus budding is dependent upon the ubiquitin ligase activity of NEDD4L and requires only the minimal HIV-1 Gag assembly regions and TSG101	PubMed
	gag	Overexpression of the HECT ubiquitin E3 ligase, NEDD4L/NEDD4-2 stimulates the release of HIV-1 constructs that lack TSG101- and ALIX-binding late domains in p6	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G42355 (e-PCR)
- UniSTS:94214

WI-12140 (e-PCR)
- UniSTS:67599

D18S1055 (e-PCR)
- UniSTS:42261

RH119039 (e-PCR)
- UniSTS:138267

A008X40 (e-PCR)
- UniSTS:17948

NEDD4L_3797 (e-PCR)
- UniSTS:462369

D18S21 (e-PCR)
- UniSTS:148514

D18S1348 (e-PCR)
- UniSTS:154692

RH68056 (e-PCR)
- UniSTS:26180

SHGC-132384 (e-PCR)
- UniSTS:183126

A004M46 (e-PCR)
- UniSTS:7261

D18S825 (e-PCR)
- UniSTS:18015

D18S1026 (e-PCR)
- UniSTS:22887

RH16409 (e-PCR)
- UniSTS:67949

RH92534 (e-PCR)
- UniSTS:86652

RH80030 (e-PCR)
- UniSTS:87680

RH15898 (e-PCR)
- UniSTS:92548

SHGC-82284 (e-PCR)
- UniSTS:183183

SGC33936 (e-PCR)
- UniSTS:42898

STS-AA019094 (e-PCR)
- UniSTS:49045

RH15883 (e-PCR)
- UniSTS:37785

RH48825 (e-PCR)
- UniSTS:71835

RH119679 (e-PCR)
- UniSTS:133048

SHGC-24432 (e-PCR)
- UniSTS:65732

SHGC-154558 (e-PCR)
- UniSTS:178136

RH68474 (e-PCR)
- UniSTS:82402

D18S887 (e-PCR)
- UniSTS:8941

G20322 (e-PCR)
- UniSTS:68597

A005M03 (e-PCR)
- UniSTS:68598

STS-H54325 (e-PCR)
- UniSTS:56315

SHGC-105843 (e-PCR)
- UniSTS:169468

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables potassium channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium channel inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-protein transferase activity	NAS Non-traceable Author Statement more info	PubMed
enables ubiquitin-protein transferase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	TAS Traceable Author Statement more info
involved_in negative regulation of potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein localization to cell surface	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of sodium ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of sodium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of caveolin-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of dendrite extension	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein monoubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of membrane depolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane repolarization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of monoatomic ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of potassium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in ventricular cardiac muscle cell action potential	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
colocalizes_with plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase NEDD4-like

Names: HECT-type E3 ubiquitin transferase NED4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; ubiquitin-protein ligase Rsp5

NP_001138436.1

EC 2.3.2.26

EC 2.3.2.36

NP_001138437.1

EC 2.3.2.26

EC 2.3.2.36

NP_001138438.1

EC 2.3.2.26

EC 2.3.2.36

NP_001138439.1

EC 2.3.2.26

EC 2.3.2.36

NP_001138440.1

EC 2.3.2.26

EC 2.3.2.36

NP_001138441.1

EC 2.3.2.26

EC 2.3.2.36

NP_001138442.1

EC 2.3.2.26

EC 2.3.2.36

NP_001138443.1

EC 2.3.2.26

EC 2.3.2.36

NP_001230889.1

EC 2.3.2.26

EC 2.3.2.36

NP_056092.2

EC 2.3.2.26

EC 2.3.2.36

XP_005266715.3

EC 2.3.2.26

EC 2.3.2.36

XP_005266717.3

EC 2.3.2.26

EC 2.3.2.36

XP_005266720.3

EC 2.3.2.26

EC 2.3.2.36

XP_006722484.3

EC 2.3.2.26

EC 2.3.2.36

XP_006722487.3

EC 2.3.2.26

EC 2.3.2.36

XP_006722488.3

EC 2.3.2.26

EC 2.3.2.36

XP_006722489.1

EC 2.3.2.26

EC 2.3.2.36

XP_006722491.1

EC 2.3.2.26

EC 2.3.2.36

XP_006722493.1

EC 2.3.2.26

EC 2.3.2.36

XP_011524189.1

EC 2.3.2.26

EC 2.3.2.36

XP_016881165.2

EC 2.3.2.26

EC 2.3.2.36

XP_016881166.2

EC 2.3.2.26

EC 2.3.2.36

XP_016881167.1

EC 2.3.2.26

EC 2.3.2.36

XP_016881168.1

EC 2.3.2.26

EC 2.3.2.36

XP_016881170.1

EC 2.3.2.26

EC 2.3.2.36

XP_024306897.1

EC 2.3.2.26

EC 2.3.2.36

XP_024306899.1

EC 2.3.2.26

EC 2.3.2.36

XP_024306902.1

EC 2.3.2.26

EC 2.3.2.36

XP_024306903.1

EC 2.3.2.26

EC 2.3.2.36

XP_024306904.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293358.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293359.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293360.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293361.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293362.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293363.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293364.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293365.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293366.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293367.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293368.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293369.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293370.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293371.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293372.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293373.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293374.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293375.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293376.1

EC 2.3.2.26

EC 2.3.2.36

XP_047293377.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174357.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174358.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174359.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174360.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174361.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174362.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174363.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174364.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174365.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174366.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174367.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174368.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174369.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174370.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174371.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174372.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174373.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174374.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174375.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174376.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174377.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174378.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174379.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174380.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174381.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174382.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174383.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174384.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174385.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174386.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174387.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174388.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174389.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174390.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174391.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174392.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174393.1

EC 2.3.2.26

EC 2.3.2.36

XP_054174394.1

EC 2.3.2.26

EC 2.3.2.36

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029954.1 RefSeqGene

Range

4849..362162

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144964.1 → NP_001138436.1 E3 ubiquitin-protein ligase NEDD4-like isoform 2

See identical proteins and their annotated locations for NP_001138436.1

Status: REVIEWED

Description

Transcript Variant: This variant (b) uses an alternate first exon, compared to variant j, which results in the use of a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus that lacks a C2 domain, compared to isoform 1. Variant b is also known as NEDD4-2C7. Variants a, b, and f encode the same isoform (2).

Source sequence(s)

AC090236, AF070601, AF385931, BC019345, BP260852, DA759940, DB317092

Consensus CDS

CCDS45875.1

UniProtKB/TrEMBL

B7Z6K0

Related

ENSP00000411947.1, ENST00000456986.5

Conserved Domains (5) summary

smart00456
Location:428 → 460

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:521 → 850

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03247
Location:198 → 381

PHA03247; large tegument protein UL36; Provisional

pfam00397
Location:266 → 295

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
NM_001144965.2 → NP_001138437.1 E3 ubiquitin-protein ligase NEDD4-like isoform 2

See identical proteins and their annotated locations for NP_001138437.1

Status: REVIEWED

Description

Transcript Variant: This variant (f) uses an alternate first exon, compared to variant j, which results in the use of a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus that lacks a C2 domain, compared to isoform 1. Variants a, b, and f encode the same isoform (2).

Source sequence(s)

AC090236, AC107896, AY112983, BC032597

Consensus CDS

CCDS45875.1

UniProtKB/TrEMBL

B7Z6K0

Conserved Domains (5) summary

smart00456
Location:428 → 460

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:521 → 850

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03247
Location:198 → 381

PHA03247; large tegument protein UL36; Provisional

pfam00397
Location:266 → 295

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
NM_001144966.3 → NP_001138438.1 E3 ubiquitin-protein ligase NEDD4-like isoform 2

See identical proteins and their annotated locations for NP_001138438.1

Status: REVIEWED

Description

Transcript Variant: This variant (a) uses an alternate first exon, compared to variant j, which results in the use of a downstream in-frame start codon. The encoded protein (isoform 2) has a shorter N-terminus that lacks a C2 domain, compared to isoform 1. Variant a is also known as NEDD4-2A. Variants a, b, and f encode the same isoform (2).

Source sequence(s)

AC090236, AF210730, AK300444, DC381911

Consensus CDS

CCDS45875.1

UniProtKB/TrEMBL

B7Z6K0

Related

ENSP00000389406.1, ENST00000431212.6

Conserved Domains (5) summary

smart00456
Location:428 → 460

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:521 → 850

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03247
Location:198 → 381

PHA03247; large tegument protein UL36; Provisional

pfam00397
Location:266 → 295

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
NM_001144967.3 → NP_001138439.1 E3 ubiquitin-protein ligase NEDD4-like isoform 1

See identical proteins and their annotated locations for NP_001138439.1

Status: REVIEWED

Description

Transcript Variant: This variant (j) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC090236, AC107896, AY312514, BQ215431

Consensus CDS

CCDS45872.1

UniProtKB/Swiss-Prot

O43165, Q3LSM7, Q7Z5F1, Q7Z5F2, Q7Z5N3, Q8N5A7, Q8WUU9, Q96PU5, Q9BW58, Q9H2W4, Q9NT88

UniProtKB/TrEMBL

A0A6Q8PFI7

Related

ENSP00000383199.2, ENST00000400345.8

Conserved Domains (5) summary

cd04033
Location:21 → 153

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:549 → 581

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:642 → 971

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03247
Location:319 → 502

PHA03247; large tegument protein UL36; Provisional

pfam00397
Location:387 → 416

WW; WW domain
NM_001144968.2 → NP_001138440.1 E3 ubiquitin-protein ligase NEDD4-like isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (g) uses an alternate first exon, compared to variant j, which results in the use of a different start codon and a protein (isoform 4) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC090236, AC107896, AY112984, BC032597

Consensus CDS

CCDS45874.1

UniProtKB/TrEMBL

A0A6Q8PFI7

Related

ENSP00000350569.4, ENST00000357895.9

Conserved Domains (6) summary

cd04033
Location:13 → 145

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:541 → 573

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:634 → 963

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:492 → 522

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:379 → 408

WW; WW domain

cl26464
Location:311 → 494

Atrophin-1; Atrophin-1 family
NM_001144969.2 → NP_001138441.1 E3 ubiquitin-protein ligase NEDD4-like isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (h) uses an alternate first exon and lacks a downstream in-frame exon, compared to variant j, which results in the use of a different start codon and a protein (isoform 5) with a shorter and distinct N-terminus, compared to isoform 1.

Source sequence(s)

AC090236, AC107896, AF070601, AY112985, BP260852, DA759940, DB317092, DQ181796

Consensus CDS

CCDS59323.1

UniProtKB/TrEMBL

A0A6Q8PFI7

Related

ENSP00000468546.1, ENST00000586263.5

Conserved Domains (5) summary

cd04033
Location:13 → 145

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:521 → 553

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:614 → 943

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:472 → 502

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:359 → 388

WW; WW domain
NM_001144970.3 → NP_001138442.1 E3 ubiquitin-protein ligase NEDD4-like isoform 6

See identical proteins and their annotated locations for NP_001138442.1

Status: REVIEWED

Description

Transcript Variant: This variant (c) uses an alternate first exon and lacks a downstream in-frame exon, compared to variant j. These differences result in the use of a downstream in-frame start codon and a protein (isoform 6) with a shorter N-terminus, compared to isoform 1. Variant c is also known as NEDD4-2B. Variants c and k encode the same isoform (6).

Source sequence(s)

AB007899, AC090236, AK294963, BC000621, DA819220

Consensus CDS

CCDS45876.1

UniProtKB/TrEMBL

B7Z2P9

Related

ENSP00000405440.1, ENST00000456173.6

Conserved Domains (4) summary

smart00456
Location:408 → 440

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:501 → 830

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:246 → 275

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
NM_001144971.2 → NP_001138443.1 E3 ubiquitin-protein ligase NEDD4-like isoform 6

See identical proteins and their annotated locations for NP_001138443.1

Status: REVIEWED

Description

Transcript Variant: This variant (k) uses two alternate exons in its 5' end and lacks a downstream in-frame exon, compared to variant j. These differences result in the use of a downstream in-frame start codon and a protein (isoform 6) with a shorter N-terminus, compared to isoform 1. Variants c and k encode the same isoform (6).

Source sequence(s)

AC090236, AC107896, AF070601, BP260852, DA759940, DB317092, DQ181796

Consensus CDS

CCDS45876.1

UniProtKB/TrEMBL

B7Z2P9

Related

ENSP00000393395.1, ENST00000435432.6

Conserved Domains (4) summary

smart00456
Location:408 → 440

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:501 → 830

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:246 → 275

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
NM_001243960.2 → NP_001230889.1 E3 ubiquitin-protein ligase NEDD4-like isoform 7

See identical proteins and their annotated locations for NP_001230889.1

Status: REVIEWED

Description

Transcript Variant: This variant (i) lacks two consecutive exons in the coding region, but maintains the reading frame, compared to variant j. The encoded isoform (7) is shorter than isoform 1.

Source sequence(s)

AC090236, AC107896, BC032597

Consensus CDS

CCDS58632.1

UniProtKB/TrEMBL

A0A6Q8PFI7

Related

ENSP00000348847.5, ENST00000356462.10

Conserved Domains (5) summary

cd04033
Location:21 → 153

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:485 → 517

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:578 → 907

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:436 → 466

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:198 → 224

WW; WW domain
NM_015277.6 → NP_056092.2 E3 ubiquitin-protein ligase NEDD4-like isoform 3

See identical proteins and their annotated locations for NP_056092.2

Status: REVIEWED

Description

Transcript Variant: This variant (d) lacks an in-frame exon, compared to variant j, resulting in a shorter protein (isoform 3), compared to isoform 1. Variant d is also known as NEDD4-2C6 and NEDL3.

Source sequence(s)

AB071179, AC090236, AC107896, BC000621

Consensus CDS

CCDS45873.1

UniProtKB/TrEMBL

A0A6Q8PFI7

Related

ENSP00000372301.3, ENST00000382850.8

Conserved Domains (4) summary

cd04033
Location:21 → 153

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:529 → 561

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:622 → 951

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:367 → 396

WW; WW domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000018.10 Reference GRCh38.p14 Primary Assembly

Range

58044226..58401540

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006722426.5 → XP_006722489.1 E3 ubiquitin-protein ligase NEDD4-like isoform X11

UniProtKB/TrEMBL

A0A6Q8PFI7

Conserved Domains (6) summary

cd04033
Location:21 → 179

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:575 → 625

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:686 → 1015

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:662 → 1016

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:526 → 556

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:413 → 442

WW; WW domain
XM_047437406.1 → XP_047293362.1 E3 ubiquitin-protein ligase NEDD4-like isoform X13
XM_047437407.1 → XP_047293363.1 E3 ubiquitin-protein ligase NEDD4-like isoform X14
XM_047437408.1 → XP_047293364.1 E3 ubiquitin-protein ligase NEDD4-like isoform X16
XM_006722428.5 → XP_006722491.1 E3 ubiquitin-protein ligase NEDD4-like isoform X15

UniProtKB/TrEMBL

A0A6Q8PFI7

Conserved Domains (6) summary

cd04033
Location:21 → 153

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:549 → 599

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:660 → 989

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:636 → 990

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:500 → 530

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:387 → 416

WW; WW domain
XM_017025678.3 → XP_016881167.1 E3 ubiquitin-protein ligase NEDD4-like isoform X18

UniProtKB/TrEMBL

A0A6Q8PFI7
XM_047437421.1 → XP_047293377.1 E3 ubiquitin-protein ligase NEDD4-like isoform X24
XM_047437418.1 → XP_047293374.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_047437420.1 → XP_047293376.1 E3 ubiquitin-protein ligase NEDD4-like isoform X23
XM_024451135.2 → XP_024306903.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10

UniProtKB/TrEMBL

B7Z2P9

Related

ENSP00000502688.1, ENST00000675801.1

Conserved Domains (4) summary

smart00456
Location:408 → 440

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:501 → 830

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:246 → 275

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_047437419.1 → XP_047293375.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_047437417.1 → XP_047293373.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_024451136.2 → XP_024306904.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10

UniProtKB/TrEMBL

B7Z2P9

Conserved Domains (4) summary

smart00456
Location:408 → 440

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:501 → 830

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:246 → 275

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_024451129.2 → XP_024306897.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9

UniProtKB/TrEMBL

B7Z6K0

Conserved Domains (5) summary

smart00456
Location:428 → 460

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:521 → 850

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03247
Location:198 → 381

PHA03247; large tegument protein UL36; Provisional

pfam00397
Location:266 → 295

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_047437402.1 → XP_047293358.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10
XM_047437404.1 → XP_047293360.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_024451131.2 → XP_024306899.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10

UniProtKB/TrEMBL

B7Z2P9

Conserved Domains (4) summary

smart00456
Location:408 → 440

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:501 → 830

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

pfam00397
Location:246 → 275

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_047437409.1 → XP_047293365.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17
XM_047437410.1 → XP_047293366.1 E3 ubiquitin-protein ligase NEDD4-like isoform X19
XM_047437403.1 → XP_047293359.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_047437405.1 → XP_047293361.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10

Related

ENSP00000502428.1, ENST00000675502.1
XM_024451134.2 → XP_024306902.1 E3 ubiquitin-protein ligase NEDD4-like isoform X22

UniProtKB/TrEMBL

B7Z6K0

Conserved Domains (6) summary

smart00456
Location:428 → 478

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:539 → 868

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:379 → 409

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:266 → 295

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain

cl26464
Location:198 → 381

Atrophin-1; Atrophin-1 family
XM_047437414.1 → XP_047293370.1 E3 ubiquitin-protein ligase NEDD4-like isoform X22
XM_011525887.4 → XP_011524189.1 E3 ubiquitin-protein ligase NEDD4-like isoform X12

UniProtKB/TrEMBL

A0A6Q8PFI7

Conserved Domains (6) summary

cd04033
Location:13 → 171

C2_NEDD4_NEDD4L; C2 domain present in the Human neural precursor cell-expressed, developmentally down-regulated 4 (NEDD4) and NEDD4-like (NEDD4L/NEDD42)

smart00456
Location:567 → 617

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:678 → 1007

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00078
Location:654 → 1008

HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

cd00201
Location:518 → 548

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:405 → 434

WW; WW domain
XM_047437411.1 → XP_047293367.1 E3 ubiquitin-protein ligase NEDD4-like isoform X20
XM_047437413.1 → XP_047293369.1 E3 ubiquitin-protein ligase NEDD4-like isoform X21
XM_047437412.1 → XP_047293368.1 E3 ubiquitin-protein ligase NEDD4-like isoform X20
XM_006722430.5 → XP_006722493.1 E3 ubiquitin-protein ligase NEDD4-like isoform X22

UniProtKB/TrEMBL

B7Z6K0

Conserved Domains (6) summary

smart00456
Location:428 → 478

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:539 → 868

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

cd00201
Location:379 → 409

WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

pfam00397
Location:266 → 295

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain

cl26464
Location:198 → 381

Atrophin-1; Atrophin-1 family
XM_017025679.3 → XP_016881168.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9

UniProtKB/TrEMBL

B7Z6K0

Conserved Domains (5) summary

smart00456
Location:428 → 460

WW; Domain with 2 conserved Trp (W) residues

smart00119
Location:521 → 850

HECTc; Domain Homologous to E6-AP Carboxyl Terminus with

PHA03247
Location:198 → 381

PHA03247; large tegument protein UL36; Provisional

pfam00397
Location:266 → 295

WW; WW domain

cl14603
Location:1 → 32

C2; C2 domain
XM_017025681.3 → XP_016881170.1 E3 ubiquitin-protein ligase NEDD4-like isoform X21

UniProtKB/TrEMBL

K7ERN1

Related

ENSP00000468332.1, ENST00000587881.1
XM_047437415.1 → XP_047293371.1 E3 ubiquitin-protein ligase NEDD4-like isoform X22
XM_047437416.1 → XP_047293372.1 E3 ubiquitin-protein ligase NEDD4-like isoform X22
XM_005266658.5 → XP_005266715.3 E3 ubiquitin-protein ligase NEDD4-like isoform X1
XM_005266660.5 → XP_005266717.3 E3 ubiquitin-protein ligase NEDD4-like isoform X2

UniProtKB/TrEMBL

A0A1B0GVY1

Related

ENSP00000490696.1, ENST00000635997.1
XM_006722421.5 → XP_006722484.3 E3 ubiquitin-protein ligase NEDD4-like isoform X3
XM_005266663.5 → XP_005266720.3 E3 ubiquitin-protein ligase NEDD4-like isoform X4
XM_017025676.2 → XP_016881165.2 E3 ubiquitin-protein ligase NEDD4-like isoform X5
XM_017025677.2 → XP_016881166.2 E3 ubiquitin-protein ligase NEDD4-like isoform X6
XM_006722424.4 → XP_006722487.3 E3 ubiquitin-protein ligase NEDD4-like isoform X7
XM_006722425.4 → XP_006722488.3 E3 ubiquitin-protein ligase NEDD4-like isoform X8

Alternate T2T-CHM13v2.0

Genomic

NC_060942.1 Alternate T2T-CHM13v2.0

Range

58244126..58602300

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054318394.1 → XP_054174369.1 E3 ubiquitin-protein ligase NEDD4-like isoform X11
XM_054318398.1 → XP_054174373.1 E3 ubiquitin-protein ligase NEDD4-like isoform X13
XM_054318399.1 → XP_054174374.1 E3 ubiquitin-protein ligase NEDD4-like isoform X14
XM_054318401.1 → XP_054174376.1 E3 ubiquitin-protein ligase NEDD4-like isoform X16
XM_054318400.1 → XP_054174375.1 E3 ubiquitin-protein ligase NEDD4-like isoform X15
XM_054318403.1 → XP_054174378.1 E3 ubiquitin-protein ligase NEDD4-like isoform X18
XM_054318418.1 → XP_054174393.1 E3 ubiquitin-protein ligase NEDD4-like isoform X24
XM_054318412.1 → XP_054174387.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_054318416.1 → XP_054174391.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10
XM_054318417.1 → XP_054174392.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10
XM_054318415.1 → XP_054174390.1 E3 ubiquitin-protein ligase NEDD4-like isoform X23
XM_054318413.1 → XP_054174388.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_054318414.1 → XP_054174389.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_054318390.1 → XP_054174365.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_054318393.1 → XP_054174368.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_054318397.1 → XP_054174372.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10
XM_054318391.1 → XP_054174366.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10
XM_054318402.1 → XP_054174377.1 E3 ubiquitin-protein ligase NEDD4-like isoform X17
XM_054318404.1 → XP_054174379.1 E3 ubiquitin-protein ligase NEDD4-like isoform X19
XM_054318392.1 → XP_054174367.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_054318396.1 → XP_054174371.1 E3 ubiquitin-protein ligase NEDD4-like isoform X10
XM_054318410.1 → XP_054174385.1 E3 ubiquitin-protein ligase NEDD4-like isoform X22
XM_054318409.1 → XP_054174384.1 E3 ubiquitin-protein ligase NEDD4-like isoform X22
XM_054318395.1 → XP_054174370.1 E3 ubiquitin-protein ligase NEDD4-like isoform X12
XM_054318405.1 → XP_054174380.1 E3 ubiquitin-protein ligase NEDD4-like isoform X20
XM_054318407.1 → XP_054174382.1 E3 ubiquitin-protein ligase NEDD4-like isoform X21
XM_054318406.1 → XP_054174381.1 E3 ubiquitin-protein ligase NEDD4-like isoform X20
XM_054318408.1 → XP_054174383.1 E3 ubiquitin-protein ligase NEDD4-like isoform X22
XM_054318411.1 → XP_054174386.1 E3 ubiquitin-protein ligase NEDD4-like isoform X9
XM_054318419.1 → XP_054174394.1 E3 ubiquitin-protein ligase NEDD4-like isoform X21
XM_054318382.1 → XP_054174357.1 E3 ubiquitin-protein ligase NEDD4-like isoform X1
XM_054318383.1 → XP_054174358.1 E3 ubiquitin-protein ligase NEDD4-like isoform X2

UniProtKB/TrEMBL

A0A1B0GVY1
XM_054318384.1 → XP_054174359.1 E3 ubiquitin-protein ligase NEDD4-like isoform X3
XM_054318385.1 → XP_054174360.1 E3 ubiquitin-protein ligase NEDD4-like isoform X4
XM_054318386.1 → XP_054174361.1 E3 ubiquitin-protein ligase NEDD4-like isoform X5
XM_054318387.1 → XP_054174362.1 E3 ubiquitin-protein ligase NEDD4-like isoform X6
XM_054318388.1 → XP_054174363.1 E3 ubiquitin-protein ligase NEDD4-like isoform X7
XM_054318389.1 → XP_054174364.1 E3 ubiquitin-protein ligase NEDD4-like isoform X8