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Zfp382 zinc finger protein 382 [ Mus musculus (house mouse) ]

Gene ID: 233060, updated on 28-Oct-2024

Summary

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Official Symbol
Zfp382provided by MGI
Official Full Name
zinc finger protein 382provided by MGI
Primary source
MGI:MGI:3588204
See related
Ensembl:ENSMUSG00000074220 AllianceGenome:MGI:3588204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KS1; Znf382; 4930428B01Rik; 5930415A09Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF382 (zinc finger protein 382). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E18 (RPKM 2.8), testis adult (RPKM 2.3) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp382 in Genome Data Viewer
Location:
7; 7 B1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (29821255..29840180)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30121833..30140758)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18504 Neighboring gene zinc finger protein 566 Neighboring gene STARR-positive B cell enhancer ABC_E869 Neighboring gene zinc finger protein 260 Neighboring gene STARR-seq mESC enhancer starr_18505 Neighboring gene STARR-seq mESC enhancer starr_18508 Neighboring gene zinc finger protein 334 pseudogene Neighboring gene STARR-seq mESC enhancer starr_18509 Neighboring gene zinc finger protein 146

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons. Ma L, et al. J Exp Med, 2021 Dec 6. PMID 34762123, Free PMC Article
  2. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
  3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  4. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
    Title: ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 382
Names
KRAB/zinc finger suppressor protein 1
multiple zinc finger and krueppel-associated box protein KS1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081007.2 → NP_001074476.1  zinc finger protein 382 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164703
    Consensus CDS
    CCDS39877.1
    UniProtKB/Swiss-Prot
    B2RXC5, Q3UYY9
    Related
    ENSMUSP00000096196.4, ENSMUST00000098596.11
    Conserved Domains (6) summary
    smart00349
    Location:42 → 102
    KRAB; krueppel associated box
    COG5048
    Location:411 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:411 → 431
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:523 → 543
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:42 → 81
    KRAB; KRAB box
    pfam13465
    Location:535 → 560
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001362158.1 → NP_001349087.1  zinc finger protein 382 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164703
    Conserved Domains (3) summary
    smart00349
    Location:42 → 102
    KRAB; krueppel associated box
    COG5048
    Location:410 → 561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:410 → 430
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001362159.1 → NP_001349088.1  zinc finger protein 382 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC164703
    Conserved Domains (3) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:381 → 532
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:381 → 401
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    29821255..29840180
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017322166.3 → XP_017177655.1  zinc finger protein 382 isoform X1

    Conserved Domains (4) summary
    smart00349
    Location:12 → 72
    KRAB; krueppel associated box
    COG5048
    Location:380 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380 → 400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:294 → 316
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RXC5.1 GenPept UniProtKB/Swiss-Prot:B2RXC5

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