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KIF13B kinesin family member 13B [ Homo sapiens (human) ]

Gene ID: 23303, updated on 5-Mar-2024

Summary

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Official Symbol
KIF13Bprovided by HGNC
Official Full Name
kinesin family member 13Bprovided by HGNC
Primary source
HGNC:HGNC:14405
See related
Ensembl:ENSG00000197892 MIM:607350; AllianceGenome:HGNC:14405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAKIN
Summary
Enables 14-3-3 protein binding activity and protein kinase binding activity. Involved in regulation of axonogenesis. Located in axon and cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney (RPKM 15.2), colon (RPKM 14.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8p12
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (29067278..29263388, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (29345440..29541595, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (28924795..29120587, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene homeobox containing 1 Neighboring gene uncharacterized LOC105379346 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:28913988-28915187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27178 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27180 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27181 Neighboring gene Sharpr-MPRA regulatory region 8281 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28924055-28924554 Neighboring gene RNA, 5S ribosomal pseudogene 260 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28927814-28928543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28932443-28932946 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28932947-28933448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:28937642-28938205 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:28945064-28945235 Neighboring gene MPRA-validated peak6973 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:29063474-29063627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27182 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27183 Neighboring gene high mobility group box 1 pseudogene 23 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19069 Neighboring gene uncharacterized LOC124901922 Neighboring gene Sharpr-MPRA regulatory region 4987 Neighboring gene uncharacterized LOC124901923 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27184 Neighboring gene Sharpr-MPRA regulatory region 3532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19070 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:29207199-29207700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:29207701-29208200 Neighboring gene dual specificity phosphatase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transient accumulation and bidirectional movement of KIF13B in primary cilia. Juhl AD, et al. J Cell Sci, 2023 Mar 1. PMID 35403186
  2. An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B. Zhu J, et al. Structure, 2016 Nov 1. PMID 27642159
  3. KIF13B mediates VEGFR2 recycling to modulate vascular permeability. Cho HD, et al. Cell Mol Life Sci, 2023 Mar 16. PMID 36928770, Free PMC Article
  4. Changes in Protein Glycosylation as a Result of Aptamer Interactions with Cancer Cells. Drabik A, et al. Proteomics Clin Appl, 2020 Jan. PMID 31550741
  5. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1. Tong Y, et al. Proc Natl Acad Sci U S A, 2010 Nov 23. PMID 21057110, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF13B mediates VEGFR2 recycling to modulate vascular permeability.
    Title: KIF13B mediates VEGFR2 recycling to modulate vascular permeability.
  2. Transient accumulation and bidirectional movement of KIF13B in primary cilia.
    Title: Transient accumulation and bidirectional movement of KIF13B in primary cilia.
  3. Changes in Protein Glycosylation as a Result of Aptamer Interactions with Cancer Cells.
    Title: Changes in Protein Glycosylation as a Result of Aptamer Interactions with Cancer Cells.
  4. Study provides evidence that KIF13B and NPHP4 are both required for establishment of a specialized caveolin-1 membrane microdomain at the ciliary transition zone, which is essential for Shh-induced accumulation of SMO in the primary cilium as well as for activation of GLI-mediated target gene expression.
    Title: KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
  5. Findings show that the high-affinity binding of KIF13B to DLG guanylate kinase (GK) domain does not require phosphorylation of KIF13B and that DLG binds to an unphosphorylated and autonomously folded domain within its stalk region (MAGUK binding stalk [MBS] domain) with high specificity and affinity.
    Title: An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B.
  6. lnc-KIF13B-1, a long non-coding RNA (rs6434720) is associated with corticobasal degeneration.
    Title: Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy.
  7. KIF13B is an essential molecular motor required for the trafficking of VEGFR2 from the Golgi, and its delivery to the endothelial cell surface mediates angiogenesis.
    Title: KIF13B regulates angiogenesis through Golgi to plasma membrane trafficking of VEGFR2.
  8. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
    Title: Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
  9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  10. These results reveal that GAKIN/KIF13B is a key intermediate linking Par1b to the regulation of axon formation.
    Title: Par1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formation.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association of lipid-lowering response to statins in combined study populations.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0639

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 14-3-3 protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in T cell activation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in cytoskeleton-dependent intracellular transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in microtubule-based movement TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein targeting TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of axonogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF13B
Names
guanylate kinase associated kinesin
kinesin 13B
kinesin-like protein GAKIN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015254.4 → NP_056069.2  kinesin-like protein KIF13B

    See identical proteins and their annotated locations for NP_056069.2

    Status: VALIDATED

    Source sequence(s)
    AB014539, AC108449, AI760125, DA068190, DA437040
    Consensus CDS
    CCDS55217.1
    UniProtKB/Swiss-Prot
    B4DGY5, B5MC45, F8VPJ2, O75134, Q9BYJ6, Q9NQT8
    Related
    ENSP00000427900.1, ENST00000524189.6
    Conserved Domains (10) summary
    smart00129
    Location:6 → 360
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:447 → 544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1704 → 1767
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:1539 → 1643
    Jun; Jun-like transcription factor
    pfam12423
    Location:756 → 802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1221 → 1279
    DUF3694; Kinesin protein
    pfam16183
    Location:357 → 469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610 → 710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:1099 → 1143
    DUF3585; Protein of unknown function (DUF3585)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    29067278..29263388 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544459.4 → XP_011542761.1  kinesin-like protein KIF13B isoform X4

    See identical proteins and their annotated locations for XP_011542761.1

    Conserved Domains (11) summary
    smart00129
    Location:9 → 296
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:395 → 508
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:383 → 480
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:3 → 296
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1661 → 1724
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:1496 → 1600
    Jun; Jun-like transcription factor
    pfam12423
    Location:692 → 738
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1157 → 1215
    DUF3694; Kinesin protein
    pfam16183
    Location:293 → 405
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:546 → 646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:1035 → 1079
    DUF3585; Protein of unknown function (DUF3585)

  2. XM_005273458.2 → XP_005273515.1  kinesin-like protein KIF13B isoform X3

    Conserved Domains (11) summary
    smart00129
    Location:6 → 360
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:459 → 572
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:447 → 544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1683 → 1746
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:1518 → 1622
    Jun; Jun-like transcription factor
    pfam12423
    Location:756 → 802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1221 → 1279
    DUF3694; Kinesin protein
    pfam16183
    Location:357 → 469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610 → 710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:1099 → 1143
    DUF3585; Protein of unknown function (DUF3585)

  3. XM_011544458.2 → XP_011542760.1  kinesin-like protein KIF13B isoform X2

    Conserved Domains (10) summary
    smart00129
    Location:6 → 360
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:447 → 544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1704 → 1767
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:1539 → 1643
    Jun; Jun-like transcription factor
    pfam12423
    Location:756 → 802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1221 → 1279
    DUF3694; Kinesin protein
    pfam16183
    Location:357 → 469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610 → 710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:1099 → 1143
    DUF3585; Protein of unknown function (DUF3585)

  4. XM_011544457.2 → XP_011542759.1  kinesin-like protein KIF13B isoform X1

    Conserved Domains (10) summary
    smart00129
    Location:6 → 360
    KISc; Kinesin motor, catalytic domain. ATPase
    cd00060
    Location:447 → 544
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:4 → 360
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1725 → 1788
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:1560 → 1664
    Jun; Jun-like transcription factor
    pfam12423
    Location:756 → 802
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1221 → 1279
    DUF3694; Kinesin protein
    pfam16183
    Location:357 → 469
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:610 → 710
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:1099 → 1143
    DUF3585; Protein of unknown function (DUF3585)

  5. XM_047421619.1 → XP_047277575.1  kinesin-like protein KIF13B isoform X4

  6. XM_011544460.4 → XP_011542762.1  kinesin-like protein KIF13B isoform X4

    See identical proteins and their annotated locations for XP_011542762.1

    Conserved Domains (11) summary
    smart00129
    Location:9 → 296
    KISc; Kinesin motor, catalytic domain. ATPase
    COG1716
    Location:395 → 508
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00060
    Location:383 → 480
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd01365
    Location:3 → 296
    KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    pfam01302
    Location:1661 → 1724
    CAP_GLY; CAP-Gly domain
    pfam03957
    Location:1496 → 1600
    Jun; Jun-like transcription factor
    pfam12423
    Location:692 → 738
    KIF1B; Kinesin protein 1B
    pfam12473
    Location:1157 → 1215
    DUF3694; Kinesin protein
    pfam16183
    Location:293 → 405
    Kinesin_assoc; Kinesin-associated
    cl23720
    Location:546 → 646
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23748
    Location:1035 → 1079
    DUF3585; Protein of unknown function (DUF3585)

  7. XM_017013257.2 → XP_016868746.1  kinesin-like protein KIF13B isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    29345440..29541595 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360193.1 → XP_054216168.1  kinesin-like protein KIF13B isoform X4

  2. XM_054360191.1 → XP_054216166.1  kinesin-like protein KIF13B isoform X3

  3. XM_054360190.1 → XP_054216165.1  kinesin-like protein KIF13B isoform X2

  4. XM_054360189.1 → XP_054216164.1  kinesin-like protein KIF13B isoform X1

  5. XM_054360194.1 → XP_054216169.1  kinesin-like protein KIF13B isoform X4

  6. XM_054360192.1 → XP_054216167.1  kinesin-like protein KIF13B isoform X4

  7. XM_054360195.1 → XP_054216170.1  kinesin-like protein KIF13B isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NQT8.2 GenPept UniProtKB/Swiss-Prot:Q9NQT8

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