U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nlrp9a NLR family, pyrin domain containing 9A [ Mus musculus (house mouse) ]

Gene ID: 233001, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Nlrp9aprovided by MGI
Official Full Name
NLR family, pyrin domain containing 9Aprovided by MGI
Primary source
MGI:MGI:2675292
See related
Ensembl:ENSMUSG00000054102 AllianceGenome:MGI:2675292
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nalp9a; D7Ertd565e; Nalp-theta
Summary
Predicted to enable ATP binding activity. Acts upstream of or within blastocyst development. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP9 (NLR family pyrin domain containing 9). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Nlrp9a in Genome Data Viewer
Location:
7 A3; 7 15.08 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (26234448..26273573)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (26535023..26574148)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18325 Neighboring gene STARR-seq mESC enhancer starr_18326 Neighboring gene NLR family, pyrin domain containing 9C Neighboring gene STARR-seq mESC enhancer starr_18327 Neighboring gene NLR family, pyrin domain containing 4A Neighboring gene STARR-seq mESC enhancer starr_18328 Neighboring gene STARR-seq mESC enhancer starr_18329 Neighboring gene STARR-seq mESC enhancer starr_18330 Neighboring gene STARR-seq mESC enhancer starr_18331 Neighboring gene vomeronasal 1 receptor 185 Neighboring gene STARR-seq mESC enhancer starr_18334 Neighboring gene cytochrome P450, family 2, subfamily b, polypeptide 23

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Involvement of Nlrp9a/b/c in mouse preimplantation development. Kanzaki S, et al. Reproduction, 2020 Aug. PMID 32413845
  2. In silico identification and structural features of six new genes similar to MATER specifically expressed in the oocyte. Dadé S, et al. Biochem Biophys Res Commun, 2004 Nov 12. PMID 15474461
  3. Structural, expression, and evolutionary analysis of mouse CIAS1. Anderson JP, et al. Gene, 2004 Aug 18. PMID 15302403, Free PMC Article
  4. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747
  5. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of canonical inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of canonical inflammasome complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NACHT, LRR and PYD domains-containing protein 9A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048219.2 → NP_001041684.1  NACHT, LRR and PYD domains-containing protein 9A isoform 1

    See identical proteins and their annotated locations for NP_001041684.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC120367, AK139925, AY364009, DV652646
    Consensus CDS
    CCDS39844.1
    UniProtKB/Swiss-Prot
    Q66X03, Q6UQE7
    UniProtKB/TrEMBL
    D3Z7F5
    Related
    ENSMUSP00000104024.3, ENSMUST00000108387.9
    Conserved Domains (4) summary
    cd00116
    Location:693 → 957
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:9 → 91
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:695 → 716
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144 → 303
    NACHT; NACHT domain

  2. NM_001048220.2 → NP_001041685.1  NACHT, LRR and PYD domains-containing protein 9A isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC120367, AK139925, AY596202, DV652646
    Consensus CDS
    CCDS39845.1
    UniProtKB/Swiss-Prot
    Q66X03, Q6UQE7
    UniProtKB/TrEMBL
    E9QKM4
    Related
    ENSMUSP00000071685.4, ENSMUST00000071780.10
    Conserved Domains (4) summary
    cd00116
    Location:638 → 902
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:9 → 91
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:640 → 661
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:144 → 303
    NACHT; NACHT domain

  3. NM_001302792.1 → NP_001289721.1  NACHT, LRR and PYD domains-containing protein 9A isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon compared to variant 1. It encodes isoform 3, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC120367, AK145355, DV652646
    UniProtKB/Swiss-Prot
    Q66X03, Q6UQE7
    Related
    ENSMUSP00000120498.2, ENSMUST00000153452.8
    Conserved Domains (3) summary
    cd00116
    Location:604 → 868
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:606 → 627
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:55 → 214
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    26234448..26273573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_194056.1: Suppressed sequence

    Description
    NM_194056.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q66X03.1 GenPept UniProtKB/Swiss-Prot:Q66X03

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools