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B3gnt8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 [ Mus musculus (house mouse) ]

Gene ID: 232984, updated on 2-Nov-2024

Summary

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Official Symbol
B3gnt8provided by MGI
Official Full Name
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8provided by MGI
Primary source
MGI:MGI:2385269
See related
Ensembl:ENSMUSG00000059479 AllianceGenome:MGI:2385269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B3galt7; B7galt7
Summary
Predicted to enable protein N-acetylglucosaminyltransferase activity. Predicted to be involved in poly-N-acetyllactosamine biosynthetic process and protein O-linked glycosylation. Predicted to be active in Golgi membrane. Is expressed in alimentary system; integumental system; nervous system; and nucleus pulposus. Orthologous to human B3GNT8 (UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 26.8), ovary adult (RPKM 11.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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See B3gnt8 in Genome Data Viewer
Location:
7 A3; 7 13.94 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25327025..25328917)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25627600..25629492)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glutamate rich 4 Neighboring gene STARR-positive B cell enhancer ABC_E9286 Neighboring gene predicted gene, 38969 Neighboring gene distal membrane arm assembly complex 2 Neighboring gene predicted gene, 57782 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E8156 Neighboring gene STARR-positive B cell enhancer ABC_E10430 Neighboring gene STARR-seq mESC enhancer starr_18309 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:26443819-26444002 Neighboring gene STARR-positive B cell enhancer ABC_E696 Neighboring gene exosome component 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. Seko A, et al. J Biol Chem, 2008 Nov 28. PMID 18826941, Free PMC Article
  2. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. up-regulation of beta3Gn-T8 in differentiated cells increases poly-N-acetyllactosamine chains by activating intrinsic beta3Gn-T2.
    Title: Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC32391

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein N-acetylglucosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein N-acetylglucosaminyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in poly-N-acetyllactosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in poly-N-acetyllactosamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in poly-N-acetyllactosamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8
Names
BGnT-8
UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 7
beta-1,3-Gn-T8
beta-1,3-N-acetylglucosaminyltransferase 8
beta3Gn-T8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001036740.2 → NP_001031817.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

    See identical proteins and their annotated locations for NP_001031817.1

    Status: VALIDATED

    Source sequence(s)
    AK042388, BY206280, BY320287, BY554292
    Consensus CDS
    CCDS20989.1
    UniProtKB/Swiss-Prot
    Q8R3I9
    Related
    ENSMUSP00000092277.5, ENSMUST00000076034.8
    Conserved Domains (1) summary
    cl21608
    Location:154 → 341
    Galactosyl_T; Galactosyltransferase

  2. NM_146184.4 → NP_666296.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

    See identical proteins and their annotated locations for NP_666296.1

    Status: VALIDATED

    Source sequence(s)
    AK042388, BY206280, BY554292
    Consensus CDS
    CCDS20989.1
    UniProtKB/Swiss-Prot
    Q8R3I9
    Related
    ENSMUST00000206824.2
    Conserved Domains (1) summary
    cl21608
    Location:154 → 341
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25327025..25328917
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539853.4 → XP_006539916.1  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 isoform X1

    See identical proteins and their annotated locations for XP_006539916.1

    UniProtKB/Swiss-Prot
    Q8R3I9
    Conserved Domains (1) summary
    cl21608
    Location:154 → 341
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3I9.1 GenPept UniProtKB/Swiss-Prot:Q8R3I9

Gene LinkOut

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