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Zfp428 zinc finger protein 428 [ Mus musculus (house mouse) ]

Gene ID: 232969, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp428provided by MGI
Official Full Name
zinc finger protein 428provided by MGI
Primary source
MGI:MGI:1916463
See related
Ensembl:ENSMUSG00000064264 AllianceGenome:MGI:1916463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf428; 2410005H09Rik
Summary
Predicted to enable metal ion binding activity. Is expressed in cortical plate. Orthologous to human ZNF428 (zinc finger protein 428). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in whole brain E14.5 (RPKM 55.2), CNS E18 (RPKM 51.2) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp428 in Genome Data Viewer
Location:
7 A3; 7 11.18 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (24203973..24215107)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (24504548..24515682)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene plasminogen activator, urokinase receptor Neighboring gene cell adhesion molecule 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:25315449-25315632 Neighboring gene immunity-related GTPase family, Q Neighboring gene STARR-seq mESC enhancer starr_18269 Neighboring gene phospholipase A2 inhibitor and LY6/PLAUR domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  2. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC38830

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  

General protein information

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Preferred Names
zinc finger protein 428

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290461.1 → NP_001277390.1  zinc finger protein 428 isoform a

    See identical proteins and their annotated locations for NP_001277390.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK139174, BX527127, CX204922
    Consensus CDS
    CCDS71912.1
    UniProtKB/TrEMBL
    H3BL05, H3BLD9
    Related
    ENSMUSP00000135601.2, ENSMUST00000176880.2

  2. NM_146183.2 → NP_666295.2  zinc finger protein 428 isoform b

    See identical proteins and their annotated locations for NP_666295.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK139174, CX200381, CX204922
    Consensus CDS
    CCDS20952.1
    UniProtKB/Swiss-Prot
    Q4V9V1, Q8C1M2, Q8QZT0
    Related
    ENSMUSP00000071318.7, ENSMUST00000071361.13

  3. NM_175142.1 → NP_780351.1  zinc finger protein 428 isoform a

    See identical proteins and their annotated locations for NP_780351.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AK139174, AV460936, CX204922
    Consensus CDS
    CCDS71912.1
    UniProtKB/TrEMBL
    H3BL05, H3BLD9
    Related
    ENSMUSP00000135750.2, ENSMUST00000177205.2

RNA

  1. NR_110958.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate splice junctions at the 5' ends of the last two exons compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK010415, AK139174, CX204922

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    24203973..24215107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539840.5 → XP_006539903.1  zinc finger protein 428 isoform X1

    See identical proteins and their annotated locations for XP_006539903.1

    UniProtKB/TrEMBL
    H3BL05, H3BLD9

  2. XM_036152948.1 → XP_036008841.1  zinc finger protein 428 isoform X2

    UniProtKB/Swiss-Prot
    Q4V9V1, Q8C1M2, Q8QZT0

  3. XM_030242437.1 → XP_030098297.1  zinc finger protein 428 isoform X2

    UniProtKB/Swiss-Prot
    Q4V9V1, Q8C1M2, Q8QZT0

  4. XM_006539839.5 → XP_006539902.1  zinc finger protein 428 isoform X1

    See identical proteins and their annotated locations for XP_006539902.1

    UniProtKB/TrEMBL
    H3BL05, H3BLD9

  5. XM_017322156.3 → XP_017177645.1  zinc finger protein 428 isoform X2

    UniProtKB/Swiss-Prot
    Q4V9V1, Q8C1M2, Q8QZT0

  6. XM_030242439.1 → XP_030098299.1  zinc finger protein 428 isoform X2

    UniProtKB/Swiss-Prot
    Q4V9V1, Q8C1M2, Q8QZT0
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C1M2.1 GenPept UniProtKB/Swiss-Prot:Q8C1M2

Gene LinkOut

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